Therapeutic application of Sertoli cells for treatment of various diseases
Sertoli cells (SCs) are immune privileged cells found in the testis that function to immunologically protect maturing germ cells from immune destruction. This immune protection is due to the blood-testis-barrier, which prevents infiltration of cytotoxic immune cells and antibodies, and SC production...
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| Veröffentlicht in: | Seminars in cell & developmental biology 2022-01, Vol.121, p.10-23 |
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| container_title | Seminars in cell & developmental biology |
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| creator | Washburn, Rachel L. Hibler, Taylor Thompson, Lea Ann Kaur, Gurvinder Dufour, Jannette M. |
| description | Sertoli cells (SCs) are immune privileged cells found in the testis that function to immunologically protect maturing germ cells from immune destruction. This immune protection is due to the blood-testis-barrier, which prevents infiltration of cytotoxic immune cells and antibodies, and SC production of immunomodulatory factors, that favor a tolerogenic environment. The ability of SCs to create an immune privileged environment has led to the exploration of their potential use in the treatment of various diseases. SCs have been utilized to create a tolerogenic ectopic microenvironment, to protect co-grafted cells, and to deliver therapeutic proteins through gene therapy. To date, numerous studies have reported the potential use of SCs for the treatment of diabetes, neurodegenerative disorders, and restoration of spermatogenesis. Additionally, SCs have been investigated as a delivery vehicle for therapeutic products to treat other diseases like Laron syndrome, muscular dystrophy, and infections. This review will provide an overview of these therapeutic applications. |
| doi_str_mv | 10.1016/j.semcdb.2021.04.007 |
| format | Article |
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This immune protection is due to the blood-testis-barrier, which prevents infiltration of cytotoxic immune cells and antibodies, and SC production of immunomodulatory factors, that favor a tolerogenic environment. The ability of SCs to create an immune privileged environment has led to the exploration of their potential use in the treatment of various diseases. SCs have been utilized to create a tolerogenic ectopic microenvironment, to protect co-grafted cells, and to deliver therapeutic proteins through gene therapy. To date, numerous studies have reported the potential use of SCs for the treatment of diabetes, neurodegenerative disorders, and restoration of spermatogenesis. Additionally, SCs have been investigated as a delivery vehicle for therapeutic products to treat other diseases like Laron syndrome, muscular dystrophy, and infections. 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This review will provide an overview of these therapeutic applications.</description><subject>Animals</subject><subject>Cell therapy</subject><subject>Cell- and Tissue-Based Therapy - methods</subject><subject>Humans</subject><subject>Immune privilege</subject><subject>Male</subject><subject>Mice</subject><subject>Sertoli cell</subject><subject>Sertoli Cells - cytology</subject><subject>Sertoli Cells - metabolism</subject><subject>Testis</subject><subject>Transplantation</subject><issn>1084-9521</issn><issn>1096-3634</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6D0R69NI6-Wi2uQgifrLgwfUc0nSKWdptTdIF_70tu3r0NAPzzrzvPIRcUsgoUHmzyQK2tiozBoxmIDKA5RGZU1Ay5ZKL46kvRKpyRmfkLIQNAAjF5CmZca4oLKWYk9f1J3rT4xCdTUzfN86a6Lpt0tXJO_rYNS6x2DQhqTufRI8mtriN03hnvOuGkFQuoAkYzslJbZqAF4e6IB-PD-v753T19vRyf7dKLZcsphY4LwW1AhXkqrQSKIJhTEkmDFuyohYKC1OoglacSywsz0UuyqqyjGJp-YJc7-_2vvsaMETdujBlNFsc82iWU1WA4qPPgoi91PouBI-17r1rjf_WFPREUW_0nqKeKGoQeqQ4rl0dHIayxepv6RfbKLjdC3D8c-fQ62Adbi1WzqONuurc_w4_nW2Ezg</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Washburn, Rachel L.</creator><creator>Hibler, Taylor</creator><creator>Thompson, Lea Ann</creator><creator>Kaur, Gurvinder</creator><creator>Dufour, Jannette M.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0110-332X</orcidid><orcidid>https://orcid.org/0000-0003-0944-775X</orcidid></search><sort><creationdate>202201</creationdate><title>Therapeutic application of Sertoli cells for treatment of various diseases</title><author>Washburn, Rachel L. ; Hibler, Taylor ; Thompson, Lea Ann ; Kaur, Gurvinder ; Dufour, Jannette M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-c033b41c4e9059bc601e0a229624a2728f49e8a8981d336e8c35454bddc21ebc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Cell therapy</topic><topic>Cell- and Tissue-Based Therapy - methods</topic><topic>Humans</topic><topic>Immune privilege</topic><topic>Male</topic><topic>Mice</topic><topic>Sertoli cell</topic><topic>Sertoli Cells - cytology</topic><topic>Sertoli Cells - metabolism</topic><topic>Testis</topic><topic>Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Washburn, Rachel L.</creatorcontrib><creatorcontrib>Hibler, Taylor</creatorcontrib><creatorcontrib>Thompson, Lea Ann</creatorcontrib><creatorcontrib>Kaur, Gurvinder</creatorcontrib><creatorcontrib>Dufour, Jannette M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in cell & developmental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Washburn, Rachel L.</au><au>Hibler, Taylor</au><au>Thompson, Lea Ann</au><au>Kaur, Gurvinder</au><au>Dufour, Jannette M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic application of Sertoli cells for treatment of various diseases</atitle><jtitle>Seminars in cell & developmental biology</jtitle><addtitle>Semin Cell Dev Biol</addtitle><date>2022-01</date><risdate>2022</risdate><volume>121</volume><spage>10</spage><epage>23</epage><pages>10-23</pages><issn>1084-9521</issn><eissn>1096-3634</eissn><abstract>Sertoli cells (SCs) are immune privileged cells found in the testis that function to immunologically protect maturing germ cells from immune destruction. This immune protection is due to the blood-testis-barrier, which prevents infiltration of cytotoxic immune cells and antibodies, and SC production of immunomodulatory factors, that favor a tolerogenic environment. The ability of SCs to create an immune privileged environment has led to the exploration of their potential use in the treatment of various diseases. SCs have been utilized to create a tolerogenic ectopic microenvironment, to protect co-grafted cells, and to deliver therapeutic proteins through gene therapy. To date, numerous studies have reported the potential use of SCs for the treatment of diabetes, neurodegenerative disorders, and restoration of spermatogenesis. Additionally, SCs have been investigated as a delivery vehicle for therapeutic products to treat other diseases like Laron syndrome, muscular dystrophy, and infections. 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell therapy Cell- and Tissue-Based Therapy - methods Humans Immune privilege Male Mice Sertoli cell Sertoli Cells - cytology Sertoli Cells - metabolism Testis Transplantation |
| title | Therapeutic application of Sertoli cells for treatment of various diseases |
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