Synthesis of NNN Chiral Ruthenium Complexes and Their Cytotoxicity Studies

Synthesis of NNN Chiral Ruthenium Complexes and Their Cytotoxicity Studies

The synthesis and characterization of chiral pincer-ruthenium complexes of the type (R2NNN)­RuCl2 (PPh3) (R = 3-methylbutyl and 3,3-dimethylbutyl) is reported here. The cytotoxicity studies of these complexes were studied and compared with the corresponding activity of achiral complexes. The cytotox...

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Veröffentlicht in:Inorganic chemistry 2021-05, Vol.60 (10), p.7422-7432
Hauptverfasser: Nandi, Pran Gobinda, Jadi, Praveen Kumar, Das, Kanu, Prathapa, Siriyara Jagannatha, Mandal, Biman B, Kumar, Akshai
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container_end_page 7432
container_issue 10
container_start_page 7422
container_title Inorganic chemistry
container_volume 60
creator Nandi, Pran Gobinda
Jadi, Praveen Kumar
Das, Kanu
Prathapa, Siriyara Jagannatha
Mandal, Biman B
Kumar, Akshai
description The synthesis and characterization of chiral pincer-ruthenium complexes of the type (R2NNN)­RuCl2 (PPh3) (R = 3-methylbutyl and 3,3-dimethylbutyl) is reported here. The cytotoxicity studies of these complexes were studied and compared with the corresponding activity of achiral complexes. The cytotoxic effect of pincer-ruthenium complexes on human dermal fibroblasts and human tongue carcinoma cells assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay displayed an inhibition of normal and cancer cell growth in a dose-dependent manner. Intracellular reactive oxygen species (ROS) level measurement, lactate dehydrogenase assay, DNA fragmentation, and necrosis studies revealed that treatment with pincer-ruthenium complexes induced a redox imbalance in SAS cells by upregulating ROS generation and caused necrotic cell death by disrupting the cellular membrane integrity.
doi_str_mv 10.1021/acs.inorgchem.1c00698
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title Synthesis of NNN Chiral Ruthenium Complexes and Their Cytotoxicity Studies
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