Early response in phosphorylation of ribosomal protein S6 is associated with sensitivity to trametinib in colorectal cancer cells

Mutations in RAS or BRAF are associated with poor prognosis and resistance to epidermal growth factor receptor (EGFR)-targeted therapy in colorectal cancer (CRC). Despite their common ability to activate downstream genes such as MEK and ERK, the therapeutic benefit of MEK inhibitors for patients wit...

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Veröffentlicht in:	Laboratory investigation 2021-08, Vol.101 (8), p.1036-1047
Hauptverfasser:	Hirashita, Yuka, Tsukamoto, Yoshiyuki, Kudo, Yoko, Kakisako, Daisuke, Kurogi, Shusaku, Hijiya, Naoki, Nakada, Chisato, Uchida, Tomohisa, Hirashita, Teijiro, Hiratsuka, Takahiro, Akagi, Tomonori, Ueda, Yoshitake, Shiroshita, Hidefumi, Etoh, Tsuyoshi, Mizukami, Kazuhiro, Honda, Koichi, Okimoto, Tadayoshi, Kodama, Masaaki, Inomata, Masafumi, Moriyama, Masatsugu, Murakami, Kazunari
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/95 14/34 631/67/1504/1885 692/53/2423 Aged Aged, 80 and over Animals Antineoplastic Agents - pharmacology Biomarkers Cancer Cell Line, Tumor Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Drug Resistance, Neoplasm - drug effects Epidermal growth factor Female Gastric cancer Growth factors Humans Immunocytochemistry Immunohistochemistry Inhibitors Laboratory Medicine Male MAP Kinase Signaling System - drug effects Medicine Medicine & Public Health MEK inhibitors Mice Mice, Inbred NOD Middle Aged Mitogen-Activated Protein Kinase Kinases - metabolism Mutants Mutation Organoids Pathology Patients Phosphorylation Phosphorylation - drug effects Protein Kinase Inhibitors - pharmacology Proteins Pyridones - pharmacology Pyrimidinones - pharmacology Raf protein Ras protein Resistance factors Ribosomal protein S6 Ribosomal Protein S6 - chemistry Ribosomal Protein S6 - metabolism Sensitivity Targeted cancer therapy Western blotting Xenografts Xenotransplantation
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