Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity

White adipose tissue (WAT) is an essential regulator of energy storage and systemic metabolic homeostasis. Regulatory networks consisting of immune and structural cells are necessary to maintain WAT metabolism, which can become impaired during obesity in mammals. Using single-cell transcriptomics an...

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Veröffentlicht in:	Nature immunology 2021-05, Vol.22 (5), p.639-653
Hauptverfasser:	Hildreth, Andrew D., Ma, Feiyang, Wong, Yung Yu, Sun, Ryan, Pellegrini, Matteo, O’Sullivan, Timothy E.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2502 692/420/256/2515 Abdominoplasty Adipocytes - immunology Adipocytes - metabolism Adipose tissue Adipose tissues Adult Biomedical and Life Sciences Biomedicine Cell Communication - immunology Cell interaction Cell Line Connective tissue cells Dendritic cells Dendritic Cells, Follicular - immunology Dendritic Cells, Follicular - metabolism Development and progression Energy storage Female Flow cytometry Health aspects Homeostasis Humans Immune system Immunity, Innate Immunology Immunoregulation Infectious Diseases Inflammation Inflammation - immunology Inflammation - pathology Lymphocytes - immunology Lymphocytes - metabolism Lymphoid cells Macrophages Macrophages - immunology Macrophages - metabolism Metabolic disorders Metabolic regulation Metabolism Monocytes Obesity Obesity - immunology Obesity - pathology Obesity - surgery Physiological aspects Resource RNA-Seq Signal Transduction - immunology Single-Cell Analysis Subcutaneous Fat, Abdominal - immunology Subcutaneous Fat, Abdominal - pathology Subcutaneous Fat, Abdominal - surgery
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