Hesperidin protects against the chlorpyrifos‐induced chronic hepato‐renal toxicity in rats associated with oxidative stress, inflammation, apoptosis, autophagy, and up‐regulation of PARP‐1/VEGF

In this study, we investigated the effects of hesperidin (HSP) on oxidants/antioxidants status, inflammation, apoptotic, and autophagic activity in hepato‐renal toxicity induced by chronic chlorpyrifos (CPF) exposure in rats. We used a total of 35 male albino rats in five groups of seven: control, H...

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Veröffentlicht in:	Environmental toxicology 2021-08, Vol.36 (8), p.1600-1617
Hauptverfasser:	Küçükler, Sefa, Çomaklı, Selim, Özdemir, Selçuk, Çağlayan, Cüneyt, Kandemir, Fatih Mehmet
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxydeoxyguanosine Albinism Alkaline phosphatase Animals Antioxidants Antioxidants - metabolism Apoptosis Autophagy BAX protein Biological stress Caspase Catalase Chlorpyrifos Creatinine Deoxyribonucleic acid DNA DNA damage ELISA Enzyme-linked immunosorbent assay Gene expression Glutathione Glutathione peroxidase Hesperidin Hesperidin - pharmacology Histopathology Immunofluorescence Inflammation Inflammation - metabolism Kidneys Liver Male Malondialdehyde Nitric-oxide synthase Nucleotide sequence Oxidants Oxidative Stress Oxidizing agents PARP‐1 PCR Peroxidase Pesticides Phagocytosis Phosphatase Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerase Inhibitors - metabolism Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Polymerase chain reaction Rats Serum Superoxide dismutase Tissue Toxicity Up-Regulation Urea Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism VEGF
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