Exploring the transition of polydopamine-shelled perfluorohexane emulsion droplets into microbubbles using small- and ultra-small-angle neutron scattering
Perfluorocarbon emulsion droplets are interesting colloidal systems with applications, ranging from diagnostics and theranostics to drug delivery, due to their controllable phase transition into microbubbles via heat application or acoustic droplet vapourisation. This work highlights the application...
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Veröffentlicht in: | Physical chemistry chemical physics : PCCP 2021-04, Vol.23 (16), p.9843-985 |
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creator | Vidallon, Mark Louis P Giles, Luke W Crawford, Simon Bishop, Alexis I Tabor, Rico F de Campo, Liliana Teo, Boon Mian |
description | Perfluorocarbon emulsion droplets are interesting colloidal systems with applications, ranging from diagnostics and theranostics to drug delivery, due to their controllable phase transition into microbubbles
via
heat application or acoustic droplet vapourisation. This work highlights the application of small- and ultra-small-angle neutron scattering (SANS and USANS, respectively), in combination with contrast variation techniques, in observing the
in situ
phase transition of polydopamine-stabilised perfluorohexane (PDA/PFH) emulsion droplets into microbubbles during heating. Results show peak USANS intensities at temperatures around 90 °C, which indicates that the phase transition of PDA/PFH emulsion droplets occurs at significantly higher temperatures than the bulk boiling point of pure liquid PFH (56 °C). Analysis and model fitting of the SANS and USANS data allowed us to estimate droplet sizes and interfacial properties at different temperatures (20 °C, 90 °C, and 20 °C after cooling), giving valuable insights about the transformation of these polydisperse emulsion droplet systems.
Perfluorocarbon emulsion droplets are interesting colloidal systems with applications in biomedicine. This work describes the use of small- and ultra-small-angle neutron scattering in studying their heat-induced phase transition into microbubbles. |
doi_str_mv | 10.1039/d1cp01146d |
format | Article |
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via
heat application or acoustic droplet vapourisation. This work highlights the application of small- and ultra-small-angle neutron scattering (SANS and USANS, respectively), in combination with contrast variation techniques, in observing the
in situ
phase transition of polydopamine-stabilised perfluorohexane (PDA/PFH) emulsion droplets into microbubbles during heating. Results show peak USANS intensities at temperatures around 90 °C, which indicates that the phase transition of PDA/PFH emulsion droplets occurs at significantly higher temperatures than the bulk boiling point of pure liquid PFH (56 °C). Analysis and model fitting of the SANS and USANS data allowed us to estimate droplet sizes and interfacial properties at different temperatures (20 °C, 90 °C, and 20 °C after cooling), giving valuable insights about the transformation of these polydisperse emulsion droplet systems.
Perfluorocarbon emulsion droplets are interesting colloidal systems with applications in biomedicine. This work describes the use of small- and ultra-small-angle neutron scattering in studying their heat-induced phase transition into microbubbles.</description><identifier>ISSN: 1463-9076</identifier><identifier>EISSN: 1463-9084</identifier><identifier>DOI: 10.1039/d1cp01146d</identifier><identifier>PMID: 33908524</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Boiling points ; Bubbles ; Droplets ; Interfacial properties ; Neutron scattering ; Neutrons ; Perfluoro compounds ; Perfluorocarbons ; Phase transitions ; Vaporization</subject><ispartof>Physical chemistry chemical physics : PCCP, 2021-04, Vol.23 (16), p.9843-985</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-a6a3f6f3e9707e61636e7677d0f65fb82564a1873a02a6a18e93695a430298b23</citedby><cites>FETCH-LOGICAL-c374t-a6a3f6f3e9707e61636e7677d0f65fb82564a1873a02a6a18e93695a430298b23</cites><orcidid>0000-0002-0026-3906 ; 0000-0003-4799-2935 ; 0000-0002-4858-1428 ; 0000-0002-9188-5451 ; 0000-0003-2926-0095</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33908524$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vidallon, Mark Louis P</creatorcontrib><creatorcontrib>Giles, Luke W</creatorcontrib><creatorcontrib>Crawford, Simon</creatorcontrib><creatorcontrib>Bishop, Alexis I</creatorcontrib><creatorcontrib>Tabor, Rico F</creatorcontrib><creatorcontrib>de Campo, Liliana</creatorcontrib><creatorcontrib>Teo, Boon Mian</creatorcontrib><title>Exploring the transition of polydopamine-shelled perfluorohexane emulsion droplets into microbubbles using small- and ultra-small-angle neutron scattering</title><title>Physical chemistry chemical physics : PCCP</title><addtitle>Phys Chem Chem Phys</addtitle><description>Perfluorocarbon emulsion droplets are interesting colloidal systems with applications, ranging from diagnostics and theranostics to drug delivery, due to their controllable phase transition into microbubbles
via
heat application or acoustic droplet vapourisation. This work highlights the application of small- and ultra-small-angle neutron scattering (SANS and USANS, respectively), in combination with contrast variation techniques, in observing the
in situ
phase transition of polydopamine-stabilised perfluorohexane (PDA/PFH) emulsion droplets into microbubbles during heating. Results show peak USANS intensities at temperatures around 90 °C, which indicates that the phase transition of PDA/PFH emulsion droplets occurs at significantly higher temperatures than the bulk boiling point of pure liquid PFH (56 °C). Analysis and model fitting of the SANS and USANS data allowed us to estimate droplet sizes and interfacial properties at different temperatures (20 °C, 90 °C, and 20 °C after cooling), giving valuable insights about the transformation of these polydisperse emulsion droplet systems.
Perfluorocarbon emulsion droplets are interesting colloidal systems with applications in biomedicine. This work describes the use of small- and ultra-small-angle neutron scattering in studying their heat-induced phase transition into microbubbles.</description><subject>Boiling points</subject><subject>Bubbles</subject><subject>Droplets</subject><subject>Interfacial properties</subject><subject>Neutron scattering</subject><subject>Neutrons</subject><subject>Perfluoro compounds</subject><subject>Perfluorocarbons</subject><subject>Phase transitions</subject><subject>Vaporization</subject><issn>1463-9076</issn><issn>1463-9084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkU1r3DAQhkVpyMcml94bBLmEglvJsiX7GDZJW1hID83ZyPY46yBLrkaC5K_010bOphvoacTomXc-XkI-cfaVM1F_63k3M84L2X8gxymIrGZV8XH_VvKInCA-MsZ4ycUhORIiEWVeHJO_N0-zcX60DzRsgQavLY5hdJa6gc7OPPdu1tNoIcMtGAM9ncEPJjrvtvCkLVCYosGloPduNhCQjjY4Oo2dd21sWwNIIy4NcNLGZFTbnkaTOmW7hLYPBqiFGHxSwU6HAMtAp-Rg0Abh7C2uyP3tze_1j2xz9_3n-mqTdUIVIdNSi0EOAmrFFEguhQQllerZIMuhrfJSFppXSmiWJ5ZXUAtZl7oQLK-rNhcrcrnTnb37EwFDM43YpWXTdi5ik5e8FsuhZUIv_kMfXfQ2TfdK5YXiSiTqy45KF0D0MDSzHyftnxvOmkWouebrX6-OXSf4_E0ythP0e_SfRQn4vAM8dvvfd8vFCy6ina0</recordid><startdate>20210428</startdate><enddate>20210428</enddate><creator>Vidallon, Mark Louis P</creator><creator>Giles, Luke W</creator><creator>Crawford, Simon</creator><creator>Bishop, Alexis I</creator><creator>Tabor, Rico F</creator><creator>de Campo, Liliana</creator><creator>Teo, Boon Mian</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0026-3906</orcidid><orcidid>https://orcid.org/0000-0003-4799-2935</orcidid><orcidid>https://orcid.org/0000-0002-4858-1428</orcidid><orcidid>https://orcid.org/0000-0002-9188-5451</orcidid><orcidid>https://orcid.org/0000-0003-2926-0095</orcidid></search><sort><creationdate>20210428</creationdate><title>Exploring the transition of polydopamine-shelled perfluorohexane emulsion droplets into microbubbles using small- and ultra-small-angle neutron scattering</title><author>Vidallon, Mark Louis P ; Giles, Luke W ; Crawford, Simon ; Bishop, Alexis I ; Tabor, Rico F ; de Campo, Liliana ; Teo, Boon Mian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-a6a3f6f3e9707e61636e7677d0f65fb82564a1873a02a6a18e93695a430298b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Boiling points</topic><topic>Bubbles</topic><topic>Droplets</topic><topic>Interfacial properties</topic><topic>Neutron scattering</topic><topic>Neutrons</topic><topic>Perfluoro compounds</topic><topic>Perfluorocarbons</topic><topic>Phase transitions</topic><topic>Vaporization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vidallon, Mark Louis P</creatorcontrib><creatorcontrib>Giles, Luke W</creatorcontrib><creatorcontrib>Crawford, Simon</creatorcontrib><creatorcontrib>Bishop, Alexis I</creatorcontrib><creatorcontrib>Tabor, Rico F</creatorcontrib><creatorcontrib>de Campo, Liliana</creatorcontrib><creatorcontrib>Teo, Boon Mian</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Physical chemistry chemical physics : PCCP</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vidallon, Mark Louis P</au><au>Giles, Luke W</au><au>Crawford, Simon</au><au>Bishop, Alexis I</au><au>Tabor, Rico F</au><au>de Campo, Liliana</au><au>Teo, Boon Mian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exploring the transition of polydopamine-shelled perfluorohexane emulsion droplets into microbubbles using small- and ultra-small-angle neutron scattering</atitle><jtitle>Physical chemistry chemical physics : PCCP</jtitle><addtitle>Phys Chem Chem Phys</addtitle><date>2021-04-28</date><risdate>2021</risdate><volume>23</volume><issue>16</issue><spage>9843</spage><epage>985</epage><pages>9843-985</pages><issn>1463-9076</issn><eissn>1463-9084</eissn><abstract>Perfluorocarbon emulsion droplets are interesting colloidal systems with applications, ranging from diagnostics and theranostics to drug delivery, due to their controllable phase transition into microbubbles
via
heat application or acoustic droplet vapourisation. This work highlights the application of small- and ultra-small-angle neutron scattering (SANS and USANS, respectively), in combination with contrast variation techniques, in observing the
in situ
phase transition of polydopamine-stabilised perfluorohexane (PDA/PFH) emulsion droplets into microbubbles during heating. Results show peak USANS intensities at temperatures around 90 °C, which indicates that the phase transition of PDA/PFH emulsion droplets occurs at significantly higher temperatures than the bulk boiling point of pure liquid PFH (56 °C). Analysis and model fitting of the SANS and USANS data allowed us to estimate droplet sizes and interfacial properties at different temperatures (20 °C, 90 °C, and 20 °C after cooling), giving valuable insights about the transformation of these polydisperse emulsion droplet systems.
Perfluorocarbon emulsion droplets are interesting colloidal systems with applications in biomedicine. This work describes the use of small- and ultra-small-angle neutron scattering in studying their heat-induced phase transition into microbubbles.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>33908524</pmid><doi>10.1039/d1cp01146d</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0026-3906</orcidid><orcidid>https://orcid.org/0000-0003-4799-2935</orcidid><orcidid>https://orcid.org/0000-0002-4858-1428</orcidid><orcidid>https://orcid.org/0000-0002-9188-5451</orcidid><orcidid>https://orcid.org/0000-0003-2926-0095</orcidid></addata></record> |
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source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
subjects | Boiling points Bubbles Droplets Interfacial properties Neutron scattering Neutrons Perfluoro compounds Perfluorocarbons Phase transitions Vaporization |
title | Exploring the transition of polydopamine-shelled perfluorohexane emulsion droplets into microbubbles using small- and ultra-small-angle neutron scattering |
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