Exploring the transition of polydopamine-shelled perfluorohexane emulsion droplets into microbubbles using small- and ultra-small-angle neutron scattering

Perfluorocarbon emulsion droplets are interesting colloidal systems with applications, ranging from diagnostics and theranostics to drug delivery, due to their controllable phase transition into microbubbles via heat application or acoustic droplet vapourisation. This work highlights the application...

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Veröffentlicht in:Physical chemistry chemical physics : PCCP 2021-04, Vol.23 (16), p.9843-985
Hauptverfasser: Vidallon, Mark Louis P, Giles, Luke W, Crawford, Simon, Bishop, Alexis I, Tabor, Rico F, de Campo, Liliana, Teo, Boon Mian
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container_issue 16
container_start_page 9843
container_title Physical chemistry chemical physics : PCCP
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creator Vidallon, Mark Louis P
Giles, Luke W
Crawford, Simon
Bishop, Alexis I
Tabor, Rico F
de Campo, Liliana
Teo, Boon Mian
description Perfluorocarbon emulsion droplets are interesting colloidal systems with applications, ranging from diagnostics and theranostics to drug delivery, due to their controllable phase transition into microbubbles via heat application or acoustic droplet vapourisation. This work highlights the application of small- and ultra-small-angle neutron scattering (SANS and USANS, respectively), in combination with contrast variation techniques, in observing the in situ phase transition of polydopamine-stabilised perfluorohexane (PDA/PFH) emulsion droplets into microbubbles during heating. Results show peak USANS intensities at temperatures around 90 °C, which indicates that the phase transition of PDA/PFH emulsion droplets occurs at significantly higher temperatures than the bulk boiling point of pure liquid PFH (56 °C). Analysis and model fitting of the SANS and USANS data allowed us to estimate droplet sizes and interfacial properties at different temperatures (20 °C, 90 °C, and 20 °C after cooling), giving valuable insights about the transformation of these polydisperse emulsion droplet systems. Perfluorocarbon emulsion droplets are interesting colloidal systems with applications in biomedicine. This work describes the use of small- and ultra-small-angle neutron scattering in studying their heat-induced phase transition into microbubbles.
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Boiling points
Bubbles
Droplets
Interfacial properties
Neutron scattering
Neutrons
Perfluoro compounds
Perfluorocarbons
Phase transitions
Vaporization
title Exploring the transition of polydopamine-shelled perfluorohexane emulsion droplets into microbubbles using small- and ultra-small-angle neutron scattering
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