Thyroid status regulates the tumor microenvironment delineating breast cancer fate

The patient’s hormonal context plays a crucial role in the outcome of cancer. However, the association between thyroid disease and breast cancer risk remains unclear. We evaluated the effect of thyroid status on breast cancer growth and dissemination in an immunocompetent mouse model. For this, hype...

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Veröffentlicht in:	Endocrine-related cancer 2021-07, Vol.28 (7), p.403-418
Hauptverfasser:	Sterle, Helena Andrea, Hildebrandt, Ximena, Valenzuela Álvarez, Matías, Paulazo, María Alejandra, Gutierrez, Luciana Mariel, Klecha, Alicia Juana, Cayrol, Florencia, Díaz Flaqué, María Celeste, Rosemblit, Cinthia, Barreiro Arcos, María Laura, Colombo, Lucas, Bolontrade, Marcela Fabiana, Medina, Vanina Araceli, Cremaschi, Graciela Alicia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast cancer Breast Neoplasms - pathology CD8 antigen Cell Line, Tumor Cytotoxicity Female Growth rate Humans Hyperthyroidism Hypothyroidism Immunoregulation Interleukin 10 Interleukin-10 - therapeutic use Lung Neoplasms - secondary Lymphocytes T Mesenchyme Metastases Metastasis Mice Mice, Inbred BALB C Monocyte chemoattractant protein 1 Stem cell transplantation Stem cells Suppressor cells Thyroid cancer Thyroid diseases Thyroid gland Thyroid hormones Triple Negative Breast Neoplasms Tumor Microenvironment Tumors γ-Interferon
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