Optimization of behavioral testing in a long-term rat model of hypoxic ischemic brain injury

•In this study we determined the optimal behavioral tests for long-term functional assessment in a rodent model of neonatal brain injury•We demonstrate that Z-scores are a useful tool for standardizing behavioral outcomes and can be used to create a functional composite score.•Rats exposed to a hypo...

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Veröffentlicht in:	Behavioural brain research 2021-07, Vol.409, p.113322-113322, Article 113322
Hauptverfasser:	Penny, Tayla R., Pham, Yen, Sutherland, Amy E., Smith, Madeleine J., Lee, Joohyung, Jenkin, Graham, Fahey, Michael C., Miller, Suzanne L., McDonald, Courtney A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Behavior Behavior Rating Scale - standards Behavior, Animal - physiology Cerebral palsy Cognitive Dysfunction - etiology Cognitive Dysfunction - physiopathology Disease Models, Animal Female Hypoxia-Ischemia, Brain - complications Hypoxia-Ischemia, Brain - physiopathology Hypoxic ischemic encephalopathy Male Motor Activity - physiology Neuropsychological Tests - standards Pregnancy Rats Rats, Sprague-Dawley
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