Circulatory miR-155 correlation with platelet and neutrophil recovery after autologous hematopoietic stem cell transplantation, a multivariate analysis
The involvement of microRNAs in the regulation of hematopoietic stem cells paves the way for their use in the management of autologous HSC transplantation (AHSCT). We aimed to evaluate the predictive value of circulatory microRNAs in extracellular vesicles (EVs) and plasma in platelet and neutrophil...
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| Veröffentlicht in: | International journal of hematology 2021-08, Vol.114 (2), p.235-245 |
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| container_title | International journal of hematology |
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| creator | Rafiee, Mohammad Farsani, Mehdi Allahbakhshian Amiri, Vahid Hajifathali, Abbas Gharehbaghian, Ahmad Mohammadi, Mohammad Hossein |
| description | The involvement of microRNAs in the regulation of hematopoietic stem cells paves the way for their use in the management of autologous HSC transplantation (AHSCT). We aimed to evaluate the predictive value of circulatory microRNAs in extracellular vesicles (EVs) and plasma in platelet and neutrophil engraftment. Circulatory miR-125b, mir-126, miR-150, and miR-155 expression was assessed in isolated EVs and plasma in samples collected from AHSCT candidates. Multivariate analysis, COX models, and ROC assessment were performed to evaluate the predictive values of these microRNAs in platelet and neutrophil engraftment. miR-155 expression following conditioning with other clinical factors such as chemotherapy courses after diagnosis was the most significant predictors of platelet/neutrophil engraftment. A CD34
+
cell count ≥ 3.5 × 10
6
/kg combined with miR-155 could be used as an engraftment predictor; however, in cases where the CD34
+
cell count was |
| doi_str_mv | 10.1007/s12185-021-03154-2 |
| format | Article |
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+
cell count ≥ 3.5 × 10
6
/kg combined with miR-155 could be used as an engraftment predictor; however, in cases where the CD34
+
cell count was < 3.5 × 10
6
/kg, this parameter lost its predictive value for engraftment and could be replaced by miR-155. The correlation between miR-155 and platelet/neutrophil engraftment even with lower numbers of CD34
+
cells suggests the importance of this microRNA in the prediction of AHSCT outcome. Moreover, miR-155 could be utilized in therapeutic approaches to provide a better outcome for patients undergoing AHSCT.</description><identifier>ISSN: 0925-5710</identifier><identifier>EISSN: 1865-3774</identifier><identifier>DOI: 10.1007/s12185-021-03154-2</identifier><identifier>PMID: 33895969</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Autografts ; CD34 antigen ; Chemotherapy ; Engraftment ; Evaluation ; Extracellular vesicles ; Hematology ; Hematopoietic stem cells ; Leukocytes (neutrophilic) ; Medicine ; Medicine & Public Health ; MicroRNAs ; miRNA ; Multivariate analysis ; Neutrophils ; Oncology ; Original Article ; Platelets ; Recovery (Medical) ; Ribonucleic acid ; RNA ; Stem cell transplantation ; Stem cells ; Transplantation</subject><ispartof>International journal of hematology, 2021-08, Vol.114 (2), p.235-245</ispartof><rights>Japanese Society of Hematology 2021</rights><rights>Japanese Society of Hematology 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-a9febece80c812ad548791fc202be4af0b73d4b83acc31c810337155aca7a0993</citedby><cites>FETCH-LOGICAL-c399t-a9febece80c812ad548791fc202be4af0b73d4b83acc31c810337155aca7a0993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12185-021-03154-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12185-021-03154-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33895969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rafiee, Mohammad</creatorcontrib><creatorcontrib>Farsani, Mehdi Allahbakhshian</creatorcontrib><creatorcontrib>Amiri, Vahid</creatorcontrib><creatorcontrib>Hajifathali, Abbas</creatorcontrib><creatorcontrib>Gharehbaghian, Ahmad</creatorcontrib><creatorcontrib>Mohammadi, Mohammad Hossein</creatorcontrib><title>Circulatory miR-155 correlation with platelet and neutrophil recovery after autologous hematopoietic stem cell transplantation, a multivariate analysis</title><title>International journal of hematology</title><addtitle>Int J Hematol</addtitle><addtitle>Int J Hematol</addtitle><description>The involvement of microRNAs in the regulation of hematopoietic stem cells paves the way for their use in the management of autologous HSC transplantation (AHSCT). We aimed to evaluate the predictive value of circulatory microRNAs in extracellular vesicles (EVs) and plasma in platelet and neutrophil engraftment. Circulatory miR-125b, mir-126, miR-150, and miR-155 expression was assessed in isolated EVs and plasma in samples collected from AHSCT candidates. Multivariate analysis, COX models, and ROC assessment were performed to evaluate the predictive values of these microRNAs in platelet and neutrophil engraftment. miR-155 expression following conditioning with other clinical factors such as chemotherapy courses after diagnosis was the most significant predictors of platelet/neutrophil engraftment. A CD34
+
cell count ≥ 3.5 × 10
6
/kg combined with miR-155 could be used as an engraftment predictor; however, in cases where the CD34
+
cell count was < 3.5 × 10
6
/kg, this parameter lost its predictive value for engraftment and could be replaced by miR-155. The correlation between miR-155 and platelet/neutrophil engraftment even with lower numbers of CD34
+
cells suggests the importance of this microRNA in the prediction of AHSCT outcome. Moreover, miR-155 could be utilized in therapeutic approaches to provide a better outcome for patients undergoing AHSCT.</description><subject>Autografts</subject><subject>CD34 antigen</subject><subject>Chemotherapy</subject><subject>Engraftment</subject><subject>Evaluation</subject><subject>Extracellular vesicles</subject><subject>Hematology</subject><subject>Hematopoietic stem cells</subject><subject>Leukocytes (neutrophilic)</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>Multivariate analysis</subject><subject>Neutrophils</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Platelets</subject><subject>Recovery (Medical)</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Transplantation</subject><issn>0925-5710</issn><issn>1865-3774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kctqHDEQRUVIiMeT_EAWQZBNFu5Ej5bVWoYhLzAYjLMW1Zpqj4y61ZHUNvMl-d1oPE4CWRgthEqn7q3iEvKGsw-cMf0xc8E71TDBGya5ahvxjKx4d64aqXX7nKyYEapRmrMTcprzLWNcs1a_JCdSdkaZc7MivzY-uSVAiWlPR3_VcKWoiylhrfk40XtfdnSuDwxYKExbOuFSUpx3PtCELt5h7YShYKKwlBjiTVwy3eFYNefosXhHc8GROgyBlgRTrnJTeZA_o0DHJRR_B8lXj2oAYZ99fkVeDBAyvn681-THl8_Xm2_NxeXX75tPF42TxpQGzIA9OuyY67iArWo7bfjgBBM9tjCwXstt23cSnJO8MkxKXVcEBxqYMXJN3h915xR_LpiLHX0-TAoT1j2sULzTLTdKVfTdf-htXFKd90Cplksp6lkTcaRcijknHOyc_Ahpbzmzh9jsMTZbY7MPsdlD09tH6aUfcfu35U9OFZBHINev6QbTP-8nZH8Dex-mtw</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Rafiee, Mohammad</creator><creator>Farsani, Mehdi Allahbakhshian</creator><creator>Amiri, Vahid</creator><creator>Hajifathali, Abbas</creator><creator>Gharehbaghian, Ahmad</creator><creator>Mohammadi, Mohammad Hossein</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20210801</creationdate><title>Circulatory miR-155 correlation with platelet and neutrophil recovery after autologous hematopoietic stem cell transplantation, a multivariate analysis</title><author>Rafiee, Mohammad ; Farsani, Mehdi Allahbakhshian ; Amiri, Vahid ; Hajifathali, Abbas ; Gharehbaghian, Ahmad ; Mohammadi, Mohammad Hossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-a9febece80c812ad548791fc202be4af0b73d4b83acc31c810337155aca7a0993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Autografts</topic><topic>CD34 antigen</topic><topic>Chemotherapy</topic><topic>Engraftment</topic><topic>Evaluation</topic><topic>Extracellular vesicles</topic><topic>Hematology</topic><topic>Hematopoietic stem cells</topic><topic>Leukocytes (neutrophilic)</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>MicroRNAs</topic><topic>miRNA</topic><topic>Multivariate analysis</topic><topic>Neutrophils</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Platelets</topic><topic>Recovery (Medical)</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rafiee, Mohammad</creatorcontrib><creatorcontrib>Farsani, Mehdi Allahbakhshian</creatorcontrib><creatorcontrib>Amiri, Vahid</creatorcontrib><creatorcontrib>Hajifathali, Abbas</creatorcontrib><creatorcontrib>Gharehbaghian, Ahmad</creatorcontrib><creatorcontrib>Mohammadi, Mohammad Hossein</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rafiee, Mohammad</au><au>Farsani, Mehdi Allahbakhshian</au><au>Amiri, Vahid</au><au>Hajifathali, Abbas</au><au>Gharehbaghian, Ahmad</au><au>Mohammadi, Mohammad Hossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulatory miR-155 correlation with platelet and neutrophil recovery after autologous hematopoietic stem cell transplantation, a multivariate analysis</atitle><jtitle>International journal of hematology</jtitle><stitle>Int J Hematol</stitle><addtitle>Int J Hematol</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>114</volume><issue>2</issue><spage>235</spage><epage>245</epage><pages>235-245</pages><issn>0925-5710</issn><eissn>1865-3774</eissn><abstract>The involvement of microRNAs in the regulation of hematopoietic stem cells paves the way for their use in the management of autologous HSC transplantation (AHSCT). We aimed to evaluate the predictive value of circulatory microRNAs in extracellular vesicles (EVs) and plasma in platelet and neutrophil engraftment. Circulatory miR-125b, mir-126, miR-150, and miR-155 expression was assessed in isolated EVs and plasma in samples collected from AHSCT candidates. Multivariate analysis, COX models, and ROC assessment were performed to evaluate the predictive values of these microRNAs in platelet and neutrophil engraftment. miR-155 expression following conditioning with other clinical factors such as chemotherapy courses after diagnosis was the most significant predictors of platelet/neutrophil engraftment. A CD34
+
cell count ≥ 3.5 × 10
6
/kg combined with miR-155 could be used as an engraftment predictor; however, in cases where the CD34
+
cell count was < 3.5 × 10
6
/kg, this parameter lost its predictive value for engraftment and could be replaced by miR-155. The correlation between miR-155 and platelet/neutrophil engraftment even with lower numbers of CD34
+
cells suggests the importance of this microRNA in the prediction of AHSCT outcome. Moreover, miR-155 could be utilized in therapeutic approaches to provide a better outcome for patients undergoing AHSCT.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>33895969</pmid><doi>10.1007/s12185-021-03154-2</doi><tpages>11</tpages></addata></record> |
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| subjects | Autografts CD34 antigen Chemotherapy Engraftment Evaluation Extracellular vesicles Hematology Hematopoietic stem cells Leukocytes (neutrophilic) Medicine Medicine & Public Health MicroRNAs miRNA Multivariate analysis Neutrophils Oncology Original Article Platelets Recovery (Medical) Ribonucleic acid RNA Stem cell transplantation Stem cells Transplantation |
| title | Circulatory miR-155 correlation with platelet and neutrophil recovery after autologous hematopoietic stem cell transplantation, a multivariate analysis |
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