Simultaneously monitoring endogenous MAPK members in single living cells by multi-channel fluorescence correlation spectroscopy

The mitogen-activated protein kinase (MAPK) pathway is a major module for cellular signal transduction. The dysregulation of the MAPK pathway has been involved in the pathogenesis of multiple diseases ranging from cancers to chronic inflammations. So far, we have not fully understood the influences...

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Veröffentlicht in:	Analyst (London) 2021-04, Vol.146 (8), p.2581-259
Hauptverfasser:	Deng, Liyun, Huang, Xiangyi, Dong, Chaoqing, Ren, Jicun
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Binding Biomolecules Cells (biology) Cellular communication Cross correlation Crosstalk Data analysis Extracellular Signal-Regulated MAP Kinases - metabolism Fluorescent indicators Hydrogen peroxide Kinases Mass spectrometry Mitogen-Activated Protein Kinase Kinases - metabolism Monitoring Pathogenesis Proteins Signal Transduction Spectroscopy Spectrum Analysis
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