FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted

Cholangiocarcinoma (CCA) is a neoplasia of the biliary tract driven by genetic, epigenetic and transcriptional mechanisms. Herein, we investigated the role of the transcription factor FOSL1, as well as its downstream transcriptional effectors, in the development and progression of CCA. FOSL1 was inv...

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Veröffentlicht in:	Journal of hepatology 2021-08, Vol.75 (2), p.363-376
Hauptverfasser:	Vallejo, Adrián, Erice, Oihane, Entrialgo-Cadierno, Rodrigo, Feliu, Iker, Guruceaga, Elizabeth, Perugorria, Maria J., Olaizola, Paula, Muggli, Alexandra, Macaya, Irati, O’Dell, Michael, Ruiz-Fernandez de Cordoba, Borja, Ortiz-Espinosa, Sergio, Hezel, Aram F., Arozarena, Imanol, Lecanda, Fernando, Avila, Matias A., Fernandez-Barrena, Maite G., Evert, Matthias, Ponz-Sarvise, Mariano, Calvisi, Diego F., Banales, Jesus M., Vicent, Silve
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Bile ducts Biliary tract Cell cycle Cell proliferation Cholangiocarcinoma Cholangiocarcinoma - diagnosis Cholangiocarcinoma - etiology Cholangiocarcinoma - genetics Chromatin Epigenetics Female FOSL1 Genetic engineering genetics Humans Hydroxymethylglutaryl-CoA Synthase - drug effects Hydroxymethylglutaryl-CoA Synthase - genetics Immunoprecipitation Male Middle Aged Molecular modelling Proto-Oncogene Proteins c-fos - adverse effects Proto-Oncogene Proteins c-fos - genetics Signal transduction targeted therapies Transcription factors Transcriptional Activation - drug effects Transcriptional Activation - genetics Tumors Xenografts
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