Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells

While CD19-directed chimeric antigen receptor (CAR) T cells can induce remission in patients with B cell acute lymphoblastic leukemia (ALL), a large subset relapse with CD19 − disease. Like CD19, CD22 is broadly expressed by B-lineage cells and thus serves as an alternative immunotherapy target in A...

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Veröffentlicht in:	Nature medicine 2021-05, Vol.27 (5), p.842-850
Hauptverfasser:	Singh, Nathan, Frey, Noelle V., Engels, Boris, Barrett, David M., Shestova, Olga, Ravikumar, Pranali, Cummins, Katherine D., Lee, Yong Gu, Pajarillo, Raymone, Chun, Inkook, Shyu, Amy, Highfill, Steven L., Price, Andrew, Zhao, Linlin, Peng, Liaomin, Granda, Brian, Ramones, Melissa, Lu, Xueqing Maggie, Christian, David A., Perazzelli, Jessica, Lacey, Simon F., Roy, Nathan H., Burkhardt, Janis K., Colomb, Florent, Damra, Mohammad, Abdel-Mohsen, Mohamed, Liu, Ting, Liu, Dongfang, Standley, Daron M., Young, Regina M., Brogdon, Jennifer L., Grupp, Stephan A., June, Carl H., Maude, Shannon L., Gill, Saar, Ruella, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	4-1BB Ligand - metabolism 631/250/1619/554 631/250/516 692/308/575 692/699/67/1059/2325 692/699/67/1990/283/2125 Acute lymphoblastic leukemia Adult Amino acids Animals Anticancer properties Antigen receptors, T cell Antigens Antigens, CD19 - metabolism Automobiles B-Lymphocytes - immunology Biomedical and Life Sciences Biomedicine Cancer Research CD19 antigen CD22 antigen CD28 antigen CD28 Antigens - genetics Cells, Cultured Cellular signal transduction Cellular therapy Chains Child Child, Preschool Chimeric antigen receptors Clinical trials Female Health aspects Humans Immunological research Immunotherapy Immunotherapy, Adoptive - methods Infectious Diseases Inflammation Interrogation Leukemia Light chains Lymphatic leukemia Lymphocytes Lymphocytes T Male Metabolic Diseases Mice Molecular Medicine Neurosciences Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Receptors Receptors, Chimeric Antigen - metabolism Remission Sialic Acid Binding Ig-like Lectin 2 - metabolism Signaling Structure Synapses T cells T-Lymphocytes - immunology T-Lymphocytes - transplantation Transcription activation Tumor Necrosis Factor Receptor Superfamily, Member 9 - metabolism Xenograft Model Antitumor Assays
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