Design, synthesis, and in vitro evaluation of 4-aminoalkyl-1(2H)-phthalazinones as potential multifunctional anti-Alzheimer’s disease agents

[Display omitted] •4-aminoalkyl-1(2H)-phthalazinone derivatives were designed and synthesized.•Most compounds exhibited significant AChE and MAO-B inhibitory activities.•Some compounds showed good inhibition of self- or Cu2+-induced Aβ aggregation.•Most compounds exhibited significant antioxidant an...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic chemistry 2021-06, Vol.111, p.104895-104895, Article 104895
Hauptverfasser:	Ye, Chanyuan, Xu, Rui, Cao, Zhongcheng, Song, Qing, Yu, Guangjun, Shi, Yichun, Liu, Zhuoling, Liu, Xiuxiu, Deng, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	4-(aminoalkyl)-1(2H)-phthalazinone derivatives Acetylcholinesterase inhibitors Alzheimer’s disease Anti-neuroinflammation Aβ aggregation inhibitors Monoamine oxidases inhibitors Multifunctional agents
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!