Knockdown of Malat1 alleviates high-glucose-induced angiogenesis through regulating miR-205-5p/VEGF-A axis

Diabetic retinopathy (DR), characterized by intraretinal vessel formation, is a major complication in diabetes. Neovascularization is an important characteristic of DR, but its formation mechanism remains unclear. In this research, Malat1, miR-205-5p, and VEGF-A levels in high glucose (HG) treat-hum...

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Veröffentlicht in:	Experimental eye research 2021-06, Vol.207, p.108585-108585, Article 108585
Hauptverfasser:	Tan, Anjun, Li, Tianrong, Ruan, Libo, Yang, Jingjing, Luo, Yuanyuan, Li, Ling, Wu, Xinan
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Antigens, CD - metabolism Blotting, Western Cadherins - metabolism Cells, Cultured Diabetic retinopathy Diabetic Retinopathy - genetics Diabetic Retinopathy - metabolism Diabetic Retinopathy - prevention & control Disease Models, Animal Endothelial-mesenchymal transition Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Gene Expression Regulation - physiology Gene Knockdown Techniques Glucose - pharmacology Humans Malat1 Mice Mice, Inbred C57BL MicroRNAs - genetics MicroRNAs - metabolism miR-205-5p Real-Time Polymerase Chain Reaction Retinal Neovascularization - genetics Retinal Neovascularization - metabolism Retinal Neovascularization - prevention & control Retinal Vessels - cytology RNA, Long Noncoding - genetics S100 Calcium-Binding Protein A4 - metabolism Transfection Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism VEGF-A
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