ARID5B rs10821936 and rs10994982 gene polymorphism and susceptibility to juvenile systemic lupus erythematosus and lupus nephritis
Background The prevalence of SLE and the spectrum of clinical manifestations vary widely in different races and geographical populations. Objective To investigate the possible role of ARID5B rs10821936 and rs10994982 polymorphism as a risk factor for the development of SLE in children (jSLE) and to...
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| Veröffentlicht in: | Lupus 2021-07, Vol.30 (8), p.1226-1232 |
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| creator | Mosaad, Youssef M Hammad, Ayman AlHarrass, Mohamed F Sallam, Rehab Shouma, Amany Hammad, Enas Ahmed, Engy Osman Abdel-Azeem, Heba A Sherif, Doaa Fawzy, Iman Elbahnasawy, Amany Abdel Twab, Hosam |
| description | Background
The prevalence of SLE and the spectrum of clinical manifestations vary widely in different races and geographical populations.
Objective
To investigate the possible role of ARID5B rs10821936 and rs10994982 polymorphism as a risk factor for the development of SLE in children (jSLE) and to evaluate their role in relation to clinical manifestations especially lupus nephritis (LN).
Methods
DNA extraction and Real-time PCR genotyping of ARID5B rs10821936 and rs10994982 were done for 104 jSLE and 282 healthy controls.
Results
The C allele and C containing genotypes (CC, CT and CC+CT) of ARID5B rs10821936 were higher in children with SLE (p = 0.009, OR = 1.56, 0.037, OR = 2.35, 0.016, OR = 1.81 and 0.008 OR = 1.88 respectively). ARID5B rs10994982 alleles, genotypes and haplotypes are not associated with jSLE (p > 0.05). The ARID5B rs10821936 and rs10994982 genotypes showed non-significant associations with LN, proliferative versus non proliferative and biopsy grades (p > 0.05).
Conclusion
ARID5B rs10821936 SNP may be a susceptibility risk factor for juvenile SLE in the studied cohort of Egyptian children. |
| doi_str_mv | 10.1177/09612033211010338 |
| format | Article |
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The prevalence of SLE and the spectrum of clinical manifestations vary widely in different races and geographical populations.
Objective
To investigate the possible role of ARID5B rs10821936 and rs10994982 polymorphism as a risk factor for the development of SLE in children (jSLE) and to evaluate their role in relation to clinical manifestations especially lupus nephritis (LN).
Methods
DNA extraction and Real-time PCR genotyping of ARID5B rs10821936 and rs10994982 were done for 104 jSLE and 282 healthy controls.
Results
The C allele and C containing genotypes (CC, CT and CC+CT) of ARID5B rs10821936 were higher in children with SLE (p = 0.009, OR = 1.56, 0.037, OR = 2.35, 0.016, OR = 1.81 and 0.008 OR = 1.88 respectively). ARID5B rs10994982 alleles, genotypes and haplotypes are not associated with jSLE (p > 0.05). The ARID5B rs10821936 and rs10994982 genotypes showed non-significant associations with LN, proliferative versus non proliferative and biopsy grades (p > 0.05).
Conclusion
ARID5B rs10821936 SNP may be a susceptibility risk factor for juvenile SLE in the studied cohort of Egyptian children.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/09612033211010338</identifier><identifier>PMID: 33888010</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Alleles ; Biopsy ; Case-Control Studies ; Child ; Children ; DNA-Binding Proteins - genetics ; Gene polymorphism ; Genetic Predisposition to Disease ; Genotype ; Genotyping ; Haplotypes ; Humans ; Lupus ; Lupus Erythematosus, Systemic - genetics ; Lupus nephritis ; Lupus Nephritis - genetics ; Nephritis ; Polymorphism ; Polymorphism, Single Nucleotide ; Risk factors ; Single-nucleotide polymorphism ; Systemic lupus erythematosus ; Transcription Factors - genetics</subject><ispartof>Lupus, 2021-07, Vol.30 (8), p.1226-1232</ispartof><rights>The Author(s) 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-4e8e0446386041a3554546f004e43976733d39178953d56a32a8b1a80a85f25f3</citedby><cites>FETCH-LOGICAL-c368t-4e8e0446386041a3554546f004e43976733d39178953d56a32a8b1a80a85f25f3</cites><orcidid>0000-0002-7148-0983</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/09612033211010338$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/09612033211010338$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33888010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mosaad, Youssef M</creatorcontrib><creatorcontrib>Hammad, Ayman</creatorcontrib><creatorcontrib>AlHarrass, Mohamed F</creatorcontrib><creatorcontrib>Sallam, Rehab</creatorcontrib><creatorcontrib>Shouma, Amany</creatorcontrib><creatorcontrib>Hammad, Enas</creatorcontrib><creatorcontrib>Ahmed, Engy Osman</creatorcontrib><creatorcontrib>Abdel-Azeem, Heba A</creatorcontrib><creatorcontrib>Sherif, Doaa</creatorcontrib><creatorcontrib>Fawzy, Iman</creatorcontrib><creatorcontrib>Elbahnasawy, Amany</creatorcontrib><creatorcontrib>Abdel Twab, Hosam</creatorcontrib><title>ARID5B rs10821936 and rs10994982 gene polymorphism and susceptibility to juvenile systemic lupus erythematosus and lupus nephritis</title><title>Lupus</title><addtitle>Lupus</addtitle><description>Background
The prevalence of SLE and the spectrum of clinical manifestations vary widely in different races and geographical populations.
Objective
To investigate the possible role of ARID5B rs10821936 and rs10994982 polymorphism as a risk factor for the development of SLE in children (jSLE) and to evaluate their role in relation to clinical manifestations especially lupus nephritis (LN).
Methods
DNA extraction and Real-time PCR genotyping of ARID5B rs10821936 and rs10994982 were done for 104 jSLE and 282 healthy controls.
Results
The C allele and C containing genotypes (CC, CT and CC+CT) of ARID5B rs10821936 were higher in children with SLE (p = 0.009, OR = 1.56, 0.037, OR = 2.35, 0.016, OR = 1.81 and 0.008 OR = 1.88 respectively). ARID5B rs10994982 alleles, genotypes and haplotypes are not associated with jSLE (p > 0.05). The ARID5B rs10821936 and rs10994982 genotypes showed non-significant associations with LN, proliferative versus non proliferative and biopsy grades (p > 0.05).
Conclusion
ARID5B rs10821936 SNP may be a susceptibility risk factor for juvenile SLE in the studied cohort of Egyptian children.</description><subject>Alleles</subject><subject>Biopsy</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Children</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Gene polymorphism</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotyping</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - genetics</subject><subject>Lupus nephritis</subject><subject>Lupus Nephritis - genetics</subject><subject>Nephritis</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk factors</subject><subject>Single-nucleotide polymorphism</subject><subject>Systemic lupus erythematosus</subject><subject>Transcription Factors - genetics</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctOHDEQRS0EChPIB2QTWWKTTYPLr7aXQCBBQooUJeuWZ6aa8ahf2O5Ivc2Xxz0DQQpiVaqqc2_ZuoR8BHYOUJYXzGrgTAgOwCBXc0AWIMuyyAt-SBbzvpiBY_I-xi1jTIDV78hxRo3JkgX5c_nj7ou6oiECMxys0NR1611rrbSG0wfskA59M7V9GDY-tjsgjnGFQ_JL3_g00dTT7fgbO98gjVNM2PoVbcZhjBTDlDbYutRnzU67n3c4bIJPPp6So9o1ET881RPy6_bm5_W34v7717vry_tiJbRJhUSDTEotjGYSnFBKKqlrxiRKYUtdCrEWFkpjlVgr7QR3ZgnOMGdUzVUtTsjnve8Q-scRY6panz_RNK7DfowVV2BmTwYZPfsP3fZj6PLrMiWBK6vFTMGeWoU-xoB1NQTfujBVwKo5oOpVQFnz6cl5XLa4_qd4TiQD53sgugd8Ofu241-21pTg</recordid><startdate>202107</startdate><enddate>202107</enddate><creator>Mosaad, Youssef M</creator><creator>Hammad, Ayman</creator><creator>AlHarrass, Mohamed F</creator><creator>Sallam, Rehab</creator><creator>Shouma, Amany</creator><creator>Hammad, Enas</creator><creator>Ahmed, Engy Osman</creator><creator>Abdel-Azeem, Heba A</creator><creator>Sherif, Doaa</creator><creator>Fawzy, Iman</creator><creator>Elbahnasawy, Amany</creator><creator>Abdel Twab, Hosam</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7148-0983</orcidid></search><sort><creationdate>202107</creationdate><title>ARID5B rs10821936 and rs10994982 gene polymorphism and susceptibility to juvenile systemic lupus erythematosus and lupus nephritis</title><author>Mosaad, Youssef M ; Hammad, Ayman ; AlHarrass, Mohamed F ; Sallam, Rehab ; Shouma, Amany ; Hammad, Enas ; Ahmed, Engy Osman ; Abdel-Azeem, Heba A ; Sherif, Doaa ; Fawzy, Iman ; Elbahnasawy, Amany ; Abdel Twab, Hosam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-4e8e0446386041a3554546f004e43976733d39178953d56a32a8b1a80a85f25f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alleles</topic><topic>Biopsy</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Children</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Gene polymorphism</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotyping</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - genetics</topic><topic>Lupus nephritis</topic><topic>Lupus Nephritis - genetics</topic><topic>Nephritis</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk factors</topic><topic>Single-nucleotide polymorphism</topic><topic>Systemic lupus erythematosus</topic><topic>Transcription Factors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mosaad, Youssef M</creatorcontrib><creatorcontrib>Hammad, Ayman</creatorcontrib><creatorcontrib>AlHarrass, Mohamed F</creatorcontrib><creatorcontrib>Sallam, Rehab</creatorcontrib><creatorcontrib>Shouma, Amany</creatorcontrib><creatorcontrib>Hammad, Enas</creatorcontrib><creatorcontrib>Ahmed, Engy Osman</creatorcontrib><creatorcontrib>Abdel-Azeem, Heba A</creatorcontrib><creatorcontrib>Sherif, Doaa</creatorcontrib><creatorcontrib>Fawzy, Iman</creatorcontrib><creatorcontrib>Elbahnasawy, Amany</creatorcontrib><creatorcontrib>Abdel Twab, Hosam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mosaad, Youssef M</au><au>Hammad, Ayman</au><au>AlHarrass, Mohamed F</au><au>Sallam, Rehab</au><au>Shouma, Amany</au><au>Hammad, Enas</au><au>Ahmed, Engy Osman</au><au>Abdel-Azeem, Heba A</au><au>Sherif, Doaa</au><au>Fawzy, Iman</au><au>Elbahnasawy, Amany</au><au>Abdel Twab, Hosam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ARID5B rs10821936 and rs10994982 gene polymorphism and susceptibility to juvenile systemic lupus erythematosus and lupus nephritis</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2021-07</date><risdate>2021</risdate><volume>30</volume><issue>8</issue><spage>1226</spage><epage>1232</epage><pages>1226-1232</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>Background
The prevalence of SLE and the spectrum of clinical manifestations vary widely in different races and geographical populations.
Objective
To investigate the possible role of ARID5B rs10821936 and rs10994982 polymorphism as a risk factor for the development of SLE in children (jSLE) and to evaluate their role in relation to clinical manifestations especially lupus nephritis (LN).
Methods
DNA extraction and Real-time PCR genotyping of ARID5B rs10821936 and rs10994982 were done for 104 jSLE and 282 healthy controls.
Results
The C allele and C containing genotypes (CC, CT and CC+CT) of ARID5B rs10821936 were higher in children with SLE (p = 0.009, OR = 1.56, 0.037, OR = 2.35, 0.016, OR = 1.81 and 0.008 OR = 1.88 respectively). ARID5B rs10994982 alleles, genotypes and haplotypes are not associated with jSLE (p > 0.05). The ARID5B rs10821936 and rs10994982 genotypes showed non-significant associations with LN, proliferative versus non proliferative and biopsy grades (p > 0.05).
Conclusion
ARID5B rs10821936 SNP may be a susceptibility risk factor for juvenile SLE in the studied cohort of Egyptian children.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>33888010</pmid><doi>10.1177/09612033211010338</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7148-0983</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0961-2033 |
| ispartof | Lupus, 2021-07, Vol.30 (8), p.1226-1232 |
| issn | 0961-2033 1477-0962 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2518545401 |
| source | MEDLINE; SAGE Complete |
| subjects | Alleles Biopsy Case-Control Studies Child Children DNA-Binding Proteins - genetics Gene polymorphism Genetic Predisposition to Disease Genotype Genotyping Haplotypes Humans Lupus Lupus Erythematosus, Systemic - genetics Lupus nephritis Lupus Nephritis - genetics Nephritis Polymorphism Polymorphism, Single Nucleotide Risk factors Single-nucleotide polymorphism Systemic lupus erythematosus Transcription Factors - genetics |
| title | ARID5B rs10821936 and rs10994982 gene polymorphism and susceptibility to juvenile systemic lupus erythematosus and lupus nephritis |
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