miR-19b-3p and miR-20a-5p are associated with the levels of antiphospholipid antibodies in patients with antiphospholipid syndrome
Monocytes play a key role in pathophysiology of antiphospholipid syndrome (APS), nevertheless it is unclear if microRNA expression is associated with particular APS features. Identify whether miR-19b-3p and miR-20a-5p expression in monocytes are associated with hallmarks of the APS. Fifty-seven APS...
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| Veröffentlicht in: | Rheumatology international 2021-07, Vol.41 (7), p.1329-1335 |
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| creator | Juárez-Vicuña, Y. Guzmán-Martín, C. A. Martínez-Martínez, L. A. Hernández-Díazcouder, A. Huesca-Gómez, C. Gamboa, R. Amezcua-Guerra, L. M. Chacon-Perez, M. Amigo, M. C. Sánchez-Muñoz, F. |
| description | Monocytes play a key role in pathophysiology of antiphospholipid syndrome (APS), nevertheless it is unclear if microRNA expression is associated with particular APS features. Identify whether miR-19b-3p and miR-20a-5p expression in monocytes are associated with hallmarks of the APS. Fifty-seven APS patients and 18 healthy controls were studied. Expression of miR-19b-3p and miR-20a-5p was measured in monocytes by RT-qPCR. Both miR-19b-3p (AUC = 0.835, 95% CI 0.733–0.938; P |
| doi_str_mv | 10.1007/s00296-021-04864-w |
| format | Article |
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P
< 0.001) discriminated APS patients from healthy individuals. A cut-off point of 1.98 for miR-19-3p and 2.18 for miR-20a-5p showed that APS patients with low microRNA expression had higher levels of IgM and IgG anticardiolipin antibodies than patients with high microRNA expression. In addition, APS patients with low microRNA expression had higher IgG anti-β
2
glycoprotein I antibody levels than their counterparts with high microRNA expression. Finally, miR-19b-3p and miR-20a-5p expression levels were significantly higher in APS patients using oral anticoagulants. Monocyte expression of miR-19b-3p and miR-20a-5p is low in APS, and patients with the lowest microRNA expression presented the highest levels of antiphospholipid antibodies.</description><identifier>ISSN: 0172-8172</identifier><identifier>EISSN: 1437-160X</identifier><identifier>DOI: 10.1007/s00296-021-04864-w</identifier><identifier>PMID: 33891159</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Antibodies ; Antibodies, Antiphospholipid - blood ; Antiphospholipid Syndrome - blood ; Antiphospholipid Syndrome - metabolism ; Autoimmune diseases ; Cross-Sectional Studies ; Female ; Genes and Disease ; Humans ; Male ; Medicine ; Medicine & Public Health ; MicroRNAs ; MicroRNAs - metabolism ; Middle Aged ; Monocytes - metabolism ; Rheumatology</subject><ispartof>Rheumatology international, 2021-07, Vol.41 (7), p.1329-1335</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-34b5f65a75770bbfe28d3827d8d6aa121eb97cebc78546417abba06aa6e3843e3</citedby><cites>FETCH-LOGICAL-c375t-34b5f65a75770bbfe28d3827d8d6aa121eb97cebc78546417abba06aa6e3843e3</cites><orcidid>0000-0002-6258-5732 ; 0000-0001-7439-2615 ; 0000-0001-6569-2851 ; 0000-0001-6556-1632 ; 0000-0002-6467-6638 ; 0000-0001-5596-354X ; 0000-0001-9102-4240 ; 0000-0002-2255-3138 ; 0000-0001-7365-9023 ; 0000-0002-6806-3484</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00296-021-04864-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00296-021-04864-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33891159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Juárez-Vicuña, Y.</creatorcontrib><creatorcontrib>Guzmán-Martín, C. A.</creatorcontrib><creatorcontrib>Martínez-Martínez, L. A.</creatorcontrib><creatorcontrib>Hernández-Díazcouder, A.</creatorcontrib><creatorcontrib>Huesca-Gómez, C.</creatorcontrib><creatorcontrib>Gamboa, R.</creatorcontrib><creatorcontrib>Amezcua-Guerra, L. M.</creatorcontrib><creatorcontrib>Chacon-Perez, M.</creatorcontrib><creatorcontrib>Amigo, M. C.</creatorcontrib><creatorcontrib>Sánchez-Muñoz, F.</creatorcontrib><title>miR-19b-3p and miR-20a-5p are associated with the levels of antiphospholipid antibodies in patients with antiphospholipid syndrome</title><title>Rheumatology international</title><addtitle>Rheumatol Int</addtitle><addtitle>Rheumatol Int</addtitle><description>Monocytes play a key role in pathophysiology of antiphospholipid syndrome (APS), nevertheless it is unclear if microRNA expression is associated with particular APS features. Identify whether miR-19b-3p and miR-20a-5p expression in monocytes are associated with hallmarks of the APS. Fifty-seven APS patients and 18 healthy controls were studied. Expression of miR-19b-3p and miR-20a-5p was measured in monocytes by RT-qPCR. Both miR-19b-3p (AUC = 0.835, 95% CI 0.733–0.938; P < 0.001) and miR-20a-5p (AUC = 0.857, 0.757–0.957;
P
< 0.001) discriminated APS patients from healthy individuals. A cut-off point of 1.98 for miR-19-3p and 2.18 for miR-20a-5p showed that APS patients with low microRNA expression had higher levels of IgM and IgG anticardiolipin antibodies than patients with high microRNA expression. In addition, APS patients with low microRNA expression had higher IgG anti-β
2
glycoprotein I antibody levels than their counterparts with high microRNA expression. Finally, miR-19b-3p and miR-20a-5p expression levels were significantly higher in APS patients using oral anticoagulants. Monocyte expression of miR-19b-3p and miR-20a-5p is low in APS, and patients with the lowest microRNA expression presented the highest levels of antiphospholipid antibodies.</description><subject>Adult</subject><subject>Antibodies</subject><subject>Antibodies, Antiphospholipid - blood</subject><subject>Antiphospholipid Syndrome - blood</subject><subject>Antiphospholipid Syndrome - metabolism</subject><subject>Autoimmune diseases</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Genes and Disease</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>MicroRNAs</subject><subject>MicroRNAs - metabolism</subject><subject>Middle Aged</subject><subject>Monocytes - metabolism</subject><subject>Rheumatology</subject><issn>0172-8172</issn><issn>1437-160X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1rFTEYhYMo9rb6B1xIwI2b1HxMPmZZitpCQRAFdyGZvONNmZlMk7m9dNtfbtqpFVpwkYST9zkngYPQO0aPGaX6U6GUt4pQzghtjGrI_gXasEZowhT99RJtKNOcmLodoMNSLmnVStHX6EAI0zIm2w26HeN3wlpPxIzdFPCd5NQRWWUG7EpJXXQLBLyPyxYvW8ADXMNQcOqrYYnzNpW6hjjHcH_hU4hQcJzw7JYI01JW6zO43EwhpxHeoFe9Gwq8fTiP0M8vn3-cnpGLb1_PT08uSCe0XIhovOyVdFpqTb3vgZsgDNfBBOUc4wx8qzvwnTayUQ3TzntH60iBMI0AcYQ-rrlzTlc7KIsdY-lgGNwEaVcsl8xwrrhqKvrhCXqZdnmqv6uUEG3LpVGV4ivV5VRKht7OOY4u31hG7V1Ddm3I1obsfUN2X03vH6J3foTwaPlbSQXECpQ6mn5D_vf2f2L_AJ59nWs</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Juárez-Vicuña, Y.</creator><creator>Guzmán-Martín, C. 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A.</au><au>Martínez-Martínez, L. A.</au><au>Hernández-Díazcouder, A.</au><au>Huesca-Gómez, C.</au><au>Gamboa, R.</au><au>Amezcua-Guerra, L. M.</au><au>Chacon-Perez, M.</au><au>Amigo, M. C.</au><au>Sánchez-Muñoz, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>miR-19b-3p and miR-20a-5p are associated with the levels of antiphospholipid antibodies in patients with antiphospholipid syndrome</atitle><jtitle>Rheumatology international</jtitle><stitle>Rheumatol Int</stitle><addtitle>Rheumatol Int</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>41</volume><issue>7</issue><spage>1329</spage><epage>1335</epage><pages>1329-1335</pages><issn>0172-8172</issn><eissn>1437-160X</eissn><abstract>Monocytes play a key role in pathophysiology of antiphospholipid syndrome (APS), nevertheless it is unclear if microRNA expression is associated with particular APS features. Identify whether miR-19b-3p and miR-20a-5p expression in monocytes are associated with hallmarks of the APS. Fifty-seven APS patients and 18 healthy controls were studied. Expression of miR-19b-3p and miR-20a-5p was measured in monocytes by RT-qPCR. Both miR-19b-3p (AUC = 0.835, 95% CI 0.733–0.938; P < 0.001) and miR-20a-5p (AUC = 0.857, 0.757–0.957;
P
< 0.001) discriminated APS patients from healthy individuals. A cut-off point of 1.98 for miR-19-3p and 2.18 for miR-20a-5p showed that APS patients with low microRNA expression had higher levels of IgM and IgG anticardiolipin antibodies than patients with high microRNA expression. In addition, APS patients with low microRNA expression had higher IgG anti-β
2
glycoprotein I antibody levels than their counterparts with high microRNA expression. Finally, miR-19b-3p and miR-20a-5p expression levels were significantly higher in APS patients using oral anticoagulants. Monocyte expression of miR-19b-3p and miR-20a-5p is low in APS, and patients with the lowest microRNA expression presented the highest levels of antiphospholipid antibodies.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33891159</pmid><doi>10.1007/s00296-021-04864-w</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6258-5732</orcidid><orcidid>https://orcid.org/0000-0001-7439-2615</orcidid><orcidid>https://orcid.org/0000-0001-6569-2851</orcidid><orcidid>https://orcid.org/0000-0001-6556-1632</orcidid><orcidid>https://orcid.org/0000-0002-6467-6638</orcidid><orcidid>https://orcid.org/0000-0001-5596-354X</orcidid><orcidid>https://orcid.org/0000-0001-9102-4240</orcidid><orcidid>https://orcid.org/0000-0002-2255-3138</orcidid><orcidid>https://orcid.org/0000-0001-7365-9023</orcidid><orcidid>https://orcid.org/0000-0002-6806-3484</orcidid></addata></record> |
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| subjects | Adult Antibodies Antibodies, Antiphospholipid - blood Antiphospholipid Syndrome - blood Antiphospholipid Syndrome - metabolism Autoimmune diseases Cross-Sectional Studies Female Genes and Disease Humans Male Medicine Medicine & Public Health MicroRNAs MicroRNAs - metabolism Middle Aged Monocytes - metabolism Rheumatology |
| title | miR-19b-3p and miR-20a-5p are associated with the levels of antiphospholipid antibodies in patients with antiphospholipid syndrome |
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