Effects of endogenous GIP in patients with type 2 diabetes

Objective The insulinotropic effect of exogenous, intravenously infused glucose-dependent insulinotropic polypeptide (GIP) is impaired in patients with type 2 diabetes. We evaluated the effects of endogenous GIP in relation to glucose and bone metabolism in patients with type 2 diabetes using a sele...

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Veröffentlicht in:	European journal of endocrinology 2021-05, Vol.185 (1), p.33-45
Hauptverfasser:	Stensen, Signe, Gasbjerg, Lærke S, Krogh, Liva L, Skov-Jeppesen, Kirsa, Sparre-Ulrich, Alexander H, Jensen, Mette H, Dela, Flemming, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens J, Rosenkilde, Mette M, Christensen, Mikkel B, Knop, Filip K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adult Aged Blood glucose Blood Glucose - drug effects Blood Glucose - metabolism Body weight Bone resorption Bone Resorption - metabolism Bone turnover Clinical Study Collagen Collagen Type I - drug effects Collagen Type I - metabolism Cross-linking Cross-Over Studies Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - metabolism Double-Blind Method Feeding Behavior - drug effects Gastric Inhibitory Polypeptide - metabolism Gastric Inhibitory Polypeptide - pharmacology GIP protein Glucagon Glucose Glucose metabolism Homeostasis Humans Insulin Insulin secretion Insulin Secretion - drug effects Insulin Secretion - physiology Lipids Male Middle Aged Obesity - metabolism Overweight Peptide Fragments - pharmacology Peptides - drug effects Peptides - metabolism Placebos Postprandial Period Random Allocation Receptors, Gastrointestinal Hormone - antagonists & inhibitors Secretion Subcutaneous Fat - drug effects Subcutaneous Fat - metabolism Triglycerides - metabolism
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