Changes in Rat Bone Tissue at the Site of the Defect In Vivo under the Effect of a Cryogenically Structured Albumin Sponge Containing a Bioregulator
We performed a morphological study of the bone tissue after implantation of a cryogenically structured albumin sponge containing a bioregulator isolated from blood serum into an extensive experimental defect of the femur. By day 90, no complete reparation of the bone tissue was achieved in the contr...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2021-04, Vol.170 (6), p.805-808 |
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| creator | Krasnov, M. S. Shaikhaliev, A. I. Korshakov, E. V. Gasbanov, G. A. Korgoloev, R. S. Sinitskaya, E. S. Sidorskii, E. V. Yamskova, V. P. Lozinsky, V. I. |
| description | We performed a morphological study of the bone tissue after implantation of a cryogenically structured albumin sponge containing a bioregulator isolated from blood serum into an extensive experimental defect of the femur. By day 90, no complete reparation of the bone tissue was achieved in the control group (without implantation of 3D carrier), a loose spongy bone is formed at the site of the defect. After implantation of the 3D carrier without serum bioregulator, the defect was closed, but the formed bone was loose and contained no inflammation foci. After the defect was filed with the albumin sponge with the bioregulator, the repair pattern corresponded to the processes of epimorphic tissue regeneration. The results suggest that cryogenically structured protein material in combination with a serum bioregulator ensured complete restoration of the bone tissue. |
| doi_str_mv | 10.1007/s10517-021-05160-0 |
| format | Article |
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S. ; Shaikhaliev, A. I. ; Korshakov, E. V. ; Gasbanov, G. A. ; Korgoloev, R. S. ; Sinitskaya, E. S. ; Sidorskii, E. V. ; Yamskova, V. P. ; Lozinsky, V. I.</creator><creatorcontrib>Krasnov, M. S. ; Shaikhaliev, A. I. ; Korshakov, E. V. ; Gasbanov, G. A. ; Korgoloev, R. S. ; Sinitskaya, E. S. ; Sidorskii, E. V. ; Yamskova, V. P. ; Lozinsky, V. I.</creatorcontrib><description>We performed a morphological study of the bone tissue after implantation of a cryogenically structured albumin sponge containing a bioregulator isolated from blood serum into an extensive experimental defect of the femur. By day 90, no complete reparation of the bone tissue was achieved in the control group (without implantation of 3D carrier), a loose spongy bone is formed at the site of the defect. After implantation of the 3D carrier without serum bioregulator, the defect was closed, but the formed bone was loose and contained no inflammation foci. After the defect was filed with the albumin sponge with the bioregulator, the repair pattern corresponded to the processes of epimorphic tissue regeneration. 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S.</creatorcontrib><creatorcontrib>Shaikhaliev, A. I.</creatorcontrib><creatorcontrib>Korshakov, E. V.</creatorcontrib><creatorcontrib>Gasbanov, G. A.</creatorcontrib><creatorcontrib>Korgoloev, R. S.</creatorcontrib><creatorcontrib>Sinitskaya, E. S.</creatorcontrib><creatorcontrib>Sidorskii, E. V.</creatorcontrib><creatorcontrib>Yamskova, V. P.</creatorcontrib><creatorcontrib>Lozinsky, V. I.</creatorcontrib><title>Changes in Rat Bone Tissue at the Site of the Defect In Vivo under the Effect of a Cryogenically Structured Albumin Sponge Containing a Bioregulator</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We performed a morphological study of the bone tissue after implantation of a cryogenically structured albumin sponge containing a bioregulator isolated from blood serum into an extensive experimental defect of the femur. 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The results suggest that cryogenically structured protein material in combination with a serum bioregulator ensured complete restoration of the bone tissue.</description><subject>Albumin</subject><subject>Biological products</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bones</subject><subject>Cancellous bone</subject><subject>Cell Biology</subject><subject>Femur</subject><subject>Inflammation</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Morphology and Patomorphology</subject><subject>Pathology</subject><subject>Regeneration</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqNkt1uEzEQhVcIREPhBbhAlpBQb7bY3j_nMg0FKlVCIoVby-udTVxt7OAfpLwHD9zZpNAUoQjthe2db85YxyfLXjN6ziht3gdGK9bklLMcNzXN6ZNswqqmyAXn7Gk2oUjlpRDiJHsRwu14pDV7np0UhZgW07qcZL_mK2WXEIix5KuK5MJZIDcmhAQEj3EFZGEiENfv9h-gBx3JlSXfzU9Hku3A7wqX_a6AmCJzv3VLsEarYdiSRfRJx-ShI7OhTWsctNg4nEnmzkZlrLFLbLowzsMyDSo6_zJ71qshwKv79TT79vHyZv45v_7y6Wo-u8511bCYcyVYw1jb9n1dFqITJceVtkXVlmVPa80bULRtNHQdr1Wna8oEU0JQzbuiq4rT7Gyvu_HuR4IQ5doEDcOgLLgUJK8YOjlai-jbv9Bbl7zF243UlJVNPS0fqKUaQBrbu-iVHkXlrCk4rdBzdpSqBZuWNb4OUuf_oPDrYG00PlNv8P8j2f9qOJzw7qBhBWqIq-CGFI2z4bHyUfBQke9B7V0IHnq58Wat_FYyKsfMyn1mJWZW7jIrR2vf3Fub2jV0f1p-hxSBYg8ELGFw_IP3R2TvAMHI8Ys</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Krasnov, M. 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S. ; Shaikhaliev, A. I. ; Korshakov, E. V. ; Gasbanov, G. A. ; Korgoloev, R. S. ; Sinitskaya, E. S. ; Sidorskii, E. V. ; Yamskova, V. P. ; Lozinsky, V. I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-2a81711bbff6438d8426430b35b44f06c27ea0b7cedd26adc60181a880c2d3d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Albumin</topic><topic>Biological products</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bones</topic><topic>Cancellous bone</topic><topic>Cell Biology</topic><topic>Femur</topic><topic>Inflammation</topic><topic>Internal Medicine</topic><topic>Laboratory Medicine</topic><topic>Morphology and Patomorphology</topic><topic>Pathology</topic><topic>Regeneration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krasnov, M. S.</creatorcontrib><creatorcontrib>Shaikhaliev, A. 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By day 90, no complete reparation of the bone tissue was achieved in the control group (without implantation of 3D carrier), a loose spongy bone is formed at the site of the defect. After implantation of the 3D carrier without serum bioregulator, the defect was closed, but the formed bone was loose and contained no inflammation foci. After the defect was filed with the albumin sponge with the bioregulator, the repair pattern corresponded to the processes of epimorphic tissue regeneration. The results suggest that cryogenically structured protein material in combination with a serum bioregulator ensured complete restoration of the bone tissue.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33893964</pmid><doi>10.1007/s10517-021-05160-0</doi><tpages>4</tpages></addata></record> |
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| subjects | Albumin Biological products Biomedical and Life Sciences Biomedicine Bones Cancellous bone Cell Biology Femur Inflammation Internal Medicine Laboratory Medicine Morphology and Patomorphology Pathology Regeneration |
| title | Changes in Rat Bone Tissue at the Site of the Defect In Vivo under the Effect of a Cryogenically Structured Albumin Sponge Containing a Bioregulator |
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