The role of mitophagy in pulmonary sepsis
Sepsis is a systemic inflammatory disease with an unacceptably high mortality rate caused by an infection or trauma that involves both innate and adaptive immune systems. Inflammatory events activate different downstream pathways leading to tissue damage and ultimately multi-organ failure. Mitochond...
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| Veröffentlicht in: | Mitochondrion 2021-07, Vol.59, p.63-75 |
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| creator | Mohsin, Mohd Tabassum, Gulnaz Ahmad, Shaniya Ali, Shakir Ali Syed, Mansoor |
| description | Sepsis is a systemic inflammatory disease with an unacceptably high mortality rate caused by an infection or trauma that involves both innate and adaptive immune systems. Inflammatory events activate different downstream pathways leading to tissue damage and ultimately multi-organ failure. Mitochondria are responsible for cellular energy, thermoregulation, metabolite biosynthesis, intracellular calcium regulation, and cell death. Damaged mitochondria induce the high Ca2+ influx through mitochondrial calcium uniporter (MCU). It also generates excessive Reactive oxygen species (ROS) and releases mtDNA into the cytoplasm, which causes induction of NLRP3 inflammasome and apoptosis. Mitophagy (Autophagy of damaged mitochondria) controls mitochondrial dynamics and function. It also maintains cellular homeostasis. This review is about how pulmonary sepsis affects the body. What is the aftermath of sepsis, and how mitophagy affects Acute Lung Injury and macrophage polarisation to overcome the damages. |
| doi_str_mv | 10.1016/j.mito.2021.04.009 |
| format | Article |
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Inflammatory events activate different downstream pathways leading to tissue damage and ultimately multi-organ failure. Mitochondria are responsible for cellular energy, thermoregulation, metabolite biosynthesis, intracellular calcium regulation, and cell death. Damaged mitochondria induce the high Ca2+ influx through mitochondrial calcium uniporter (MCU). It also generates excessive Reactive oxygen species (ROS) and releases mtDNA into the cytoplasm, which causes induction of NLRP3 inflammasome and apoptosis. Mitophagy (Autophagy of damaged mitochondria) controls mitochondrial dynamics and function. It also maintains cellular homeostasis. This review is about how pulmonary sepsis affects the body. 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| ispartof | Mitochondrion, 2021-07, Vol.59, p.63-75 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | ALI Calcium - metabolism Calcium Channels - metabolism DNA, Mitochondrial - metabolism Humans Inflammasomes - metabolism Intracellular calcium Macrophage polarisation Mitochondria - genetics Mitochondria - metabolism Mitochondrial Dynamics Mitophagy Oxidative stress Pneumonia - metabolism Pulmonary sepsis Sepsis Sepsis - metabolism |
| title | The role of mitophagy in pulmonary sepsis |
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