New Thyrointegrin αvβ3 Antagonist with a Scalable Synthesis, Brain Penetration, and Potent Activity against Glioblastoma Multiforme

We have previously reported that the αvβ3 inhibitor P-bi-TAT, a bifunctional version of the thyroid hormone metabolite tetraiodothyroacetic acid (tetrac) conjugated to polyethylene glycol (PEG) MW 4000, has excellent efficacy in a glioblastoma multiforme (GBM) mouse model. However, bioanalysis probl...

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Veröffentlicht in:	Journal of medicinal chemistry 2021-05, Vol.64 (9), p.6300-6309
Hauptverfasser:	Hay, Bruce A, Godugu, Kavitha, Darwish, Noureldien H. E, Fujioka, Kazutoshi, Sudha, Thangirala, Karakus, Ozlem Ozen, Mousa, Shaker A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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