Effects of opioids on respiration assessed by a contact-free unconstraint respiratory monitor with load cells under the bed in patients with advanced cancer
Through usage of a novel contact-free unconstraint vital sign monitoring system with four load cells placed under the bed legs allowing continuous measurements of respiratory changes of center of gravity on the bed, this study is the first to assess detailed respiratory characteristics throughout da...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2021-06, Vol.130 (6), p.1743-1753 |
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| creator | Hasegawa, Makoto Nozaki-Taguchi, Natsuko Shono, Koyo Mizuno, Yuko Takai, Hiromichi Sato, Yasunori Isono, Shiroh |
| description | Through usage of a novel contact-free unconstraint vital sign monitoring system with four load cells placed under the bed legs allowing continuous measurements of respiratory changes of center of gravity on the bed, this study is the first to assess detailed respiratory characteristics throughout day and night periods without interference of daily activities in patients with advanced cancer receiving opioids. Respiratory rhythm irregularity is a predominant specific feature of opioid dose-dependent respiratory depression particularly in female patients with advanced cancer.
Nocturnal periodic breathing of chronic opioid users has been predominantly documented by the use of polysomnography. No previous studies have assessed the opioid effects of respiratory rhythms throughout the day without the use of physical restraint. We recently developed a contact-free unconstraint vital sign monitoring system with four load cells placed under the bed legs, which allows continuous measurements of respiratory change at the center of gravity on the bed. We aimed to reveal details of the patient’s 24-h respiratory status under a monitoring system and to test the hypothesis that respiratory rhythm abnormalities are opioid dose-dependent and worsen during the night time. Continuous 48-h respiratory measurements were successfully performed in 51 patients with advanced cancer (12 opioid-free patients and 39 opioid-receiving patients). Medians of respiratory variables with minimal body movement artifacts were calculated for each 8-h split time period. Compared with opioid-free patients, opioid-receiving patients had slower respiratory rate with higher respiratory rate irregularity without changing tidal centroid shift regardless of the time period. Irregular ataxic breathing was only identified in opioid-receiving patients (33%, P = 0.023) whereas incidence rate of periodic breathing did not differ between the groups. Multivariate regression analyses revealed that opioid dose was an independent risk factor for occurrence of irregular breathing [odds ratio 1.81 (95% CI: 1.39–2.36), P < 0.001], and ataxic breathing [odds ratio 2.08 (95% CI: 1.60–2.71), P < 0.001]. Females developed the ataxic breathing at lower opioid dose compared with males. We conclude that respiratory rhythm irregularity is a predominant specific feature of opioid dose-dependent respiratory depression particularly in female patients with advanced cancer.
NEW & NOTEWORTHY Through usage of a novel contact-fre |
| doi_str_mv | 10.1152/japplphysiol.00904.2020 |
| format | Article |
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Nocturnal periodic breathing of chronic opioid users has been predominantly documented by the use of polysomnography. No previous studies have assessed the opioid effects of respiratory rhythms throughout the day without the use of physical restraint. We recently developed a contact-free unconstraint vital sign monitoring system with four load cells placed under the bed legs, which allows continuous measurements of respiratory change at the center of gravity on the bed. We aimed to reveal details of the patient’s 24-h respiratory status under a monitoring system and to test the hypothesis that respiratory rhythm abnormalities are opioid dose-dependent and worsen during the night time. Continuous 48-h respiratory measurements were successfully performed in 51 patients with advanced cancer (12 opioid-free patients and 39 opioid-receiving patients). Medians of respiratory variables with minimal body movement artifacts were calculated for each 8-h split time period. Compared with opioid-free patients, opioid-receiving patients had slower respiratory rate with higher respiratory rate irregularity without changing tidal centroid shift regardless of the time period. Irregular ataxic breathing was only identified in opioid-receiving patients (33%, P = 0.023) whereas incidence rate of periodic breathing did not differ between the groups. Multivariate regression analyses revealed that opioid dose was an independent risk factor for occurrence of irregular breathing [odds ratio 1.81 (95% CI: 1.39–2.36), P < 0.001], and ataxic breathing [odds ratio 2.08 (95% CI: 1.60–2.71), P < 0.001]. Females developed the ataxic breathing at lower opioid dose compared with males. We conclude that respiratory rhythm irregularity is a predominant specific feature of opioid dose-dependent respiratory depression particularly in female patients with advanced cancer.
NEW & NOTEWORTHY Through usage of a novel contact-free unconstraint vital sign monitoring system with four load cells placed under the bed legs allowing continuous measurements of respiratory changes of center of gravity on the bed, this study is the first to assess detailed respiratory characteristics throughout day and night periods without interference of daily activities in patients with advanced cancer receiving opioids. Respiratory rhythm irregularity is a predominant specific feature of opioid dose-dependent respiratory depression particularly in female patients with advanced cancer.</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.00904.2020</identifier><language>eng</language><publisher>Bethesda: American Physiological Society</publisher><subject>Abnormalities ; Bed load ; Breathing ; Cancer ; Center of gravity ; Centroids ; Irregularities ; Load cells ; Monitoring ; Monitoring systems ; Narcotics ; Opioids ; Respiration ; Respiratory rate ; Rhythm ; Risk analysis ; Risk factors</subject><ispartof>Journal of applied physiology (1985), 2021-06, Vol.130 (6), p.1743-1753</ispartof><rights>Copyright American Physiological Society Jun 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c318t-b309ac3c0be0f8ed68a01b796177a69a2ad3be546b61d5d82cc7ca98199168903</citedby><cites>FETCH-LOGICAL-c318t-b309ac3c0be0f8ed68a01b796177a69a2ad3be546b61d5d82cc7ca98199168903</cites><orcidid>0000-0002-1875-6098</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids></links><search><creatorcontrib>Hasegawa, Makoto</creatorcontrib><creatorcontrib>Nozaki-Taguchi, Natsuko</creatorcontrib><creatorcontrib>Shono, Koyo</creatorcontrib><creatorcontrib>Mizuno, Yuko</creatorcontrib><creatorcontrib>Takai, Hiromichi</creatorcontrib><creatorcontrib>Sato, Yasunori</creatorcontrib><creatorcontrib>Isono, Shiroh</creatorcontrib><title>Effects of opioids on respiration assessed by a contact-free unconstraint respiratory monitor with load cells under the bed in patients with advanced cancer</title><title>Journal of applied physiology (1985)</title><description>Through usage of a novel contact-free unconstraint vital sign monitoring system with four load cells placed under the bed legs allowing continuous measurements of respiratory changes of center of gravity on the bed, this study is the first to assess detailed respiratory characteristics throughout day and night periods without interference of daily activities in patients with advanced cancer receiving opioids. Respiratory rhythm irregularity is a predominant specific feature of opioid dose-dependent respiratory depression particularly in female patients with advanced cancer.
Nocturnal periodic breathing of chronic opioid users has been predominantly documented by the use of polysomnography. No previous studies have assessed the opioid effects of respiratory rhythms throughout the day without the use of physical restraint. We recently developed a contact-free unconstraint vital sign monitoring system with four load cells placed under the bed legs, which allows continuous measurements of respiratory change at the center of gravity on the bed. We aimed to reveal details of the patient’s 24-h respiratory status under a monitoring system and to test the hypothesis that respiratory rhythm abnormalities are opioid dose-dependent and worsen during the night time. Continuous 48-h respiratory measurements were successfully performed in 51 patients with advanced cancer (12 opioid-free patients and 39 opioid-receiving patients). Medians of respiratory variables with minimal body movement artifacts were calculated for each 8-h split time period. Compared with opioid-free patients, opioid-receiving patients had slower respiratory rate with higher respiratory rate irregularity without changing tidal centroid shift regardless of the time period. Irregular ataxic breathing was only identified in opioid-receiving patients (33%, P = 0.023) whereas incidence rate of periodic breathing did not differ between the groups. Multivariate regression analyses revealed that opioid dose was an independent risk factor for occurrence of irregular breathing [odds ratio 1.81 (95% CI: 1.39–2.36), P < 0.001], and ataxic breathing [odds ratio 2.08 (95% CI: 1.60–2.71), P < 0.001]. Females developed the ataxic breathing at lower opioid dose compared with males. We conclude that respiratory rhythm irregularity is a predominant specific feature of opioid dose-dependent respiratory depression particularly in female patients with advanced cancer.
NEW & NOTEWORTHY Through usage of a novel contact-free unconstraint vital sign monitoring system with four load cells placed under the bed legs allowing continuous measurements of respiratory changes of center of gravity on the bed, this study is the first to assess detailed respiratory characteristics throughout day and night periods without interference of daily activities in patients with advanced cancer receiving opioids. Respiratory rhythm irregularity is a predominant specific feature of opioid dose-dependent respiratory depression particularly in female patients with advanced cancer.</description><subject>Abnormalities</subject><subject>Bed load</subject><subject>Breathing</subject><subject>Cancer</subject><subject>Center of gravity</subject><subject>Centroids</subject><subject>Irregularities</subject><subject>Load cells</subject><subject>Monitoring</subject><subject>Monitoring systems</subject><subject>Narcotics</subject><subject>Opioids</subject><subject>Respiration</subject><subject>Respiratory rate</subject><subject>Rhythm</subject><subject>Risk analysis</subject><subject>Risk factors</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkc9qGzEQxkVJoY7bZ6ggl17WGWl3Je0xGDcpGHppz8uspMUya2kryQ1-lzxsZTuEEhiYb5jf_IGPkK8MVoy1_H6P8zzNu1NyYVoBdNCsOHD4QBalyysmgN2QhZItVLJV8hO5TWkPwJqmZQvyshlHq3OiYaRhdsGZIj2NNs0uYnZFY0q2hKHDiSLVwWfUuRqjtfToS5lyROfz20yIJ3oI3hVBn13e0SmgodpOUyoDxkaad5YOZaHzdC43rC_3LySav-h16ehzip_JxxGnZL-85iX5_X3za_1UbX8-_lg_bCtdM5WroYYOda1hsDAqa4RCYIPsBJMSRYccTT3YthGDYKY1imstNXaKdR0TqoN6Sb5d984x_DnalPuDS-eH0dtwTD1vmeKctyALevcO3Ydj9OW7QjVCNApqXih5pXQMKUU79nN0B4ynnkF_dq3_37X-4lp_dq3-B-_8koU</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Hasegawa, Makoto</creator><creator>Nozaki-Taguchi, Natsuko</creator><creator>Shono, Koyo</creator><creator>Mizuno, Yuko</creator><creator>Takai, Hiromichi</creator><creator>Sato, Yasunori</creator><creator>Isono, Shiroh</creator><general>American Physiological Society</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1875-6098</orcidid></search><sort><creationdate>20210601</creationdate><title>Effects of opioids on respiration assessed by a contact-free unconstraint respiratory monitor with load cells under the bed in patients with advanced cancer</title><author>Hasegawa, Makoto ; Nozaki-Taguchi, Natsuko ; Shono, Koyo ; Mizuno, Yuko ; Takai, Hiromichi ; Sato, Yasunori ; Isono, Shiroh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c318t-b309ac3c0be0f8ed68a01b796177a69a2ad3be546b61d5d82cc7ca98199168903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abnormalities</topic><topic>Bed load</topic><topic>Breathing</topic><topic>Cancer</topic><topic>Center of gravity</topic><topic>Centroids</topic><topic>Irregularities</topic><topic>Load cells</topic><topic>Monitoring</topic><topic>Monitoring systems</topic><topic>Narcotics</topic><topic>Opioids</topic><topic>Respiration</topic><topic>Respiratory rate</topic><topic>Rhythm</topic><topic>Risk analysis</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasegawa, Makoto</creatorcontrib><creatorcontrib>Nozaki-Taguchi, Natsuko</creatorcontrib><creatorcontrib>Shono, Koyo</creatorcontrib><creatorcontrib>Mizuno, Yuko</creatorcontrib><creatorcontrib>Takai, Hiromichi</creatorcontrib><creatorcontrib>Sato, Yasunori</creatorcontrib><creatorcontrib>Isono, Shiroh</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasegawa, Makoto</au><au>Nozaki-Taguchi, Natsuko</au><au>Shono, Koyo</au><au>Mizuno, Yuko</au><au>Takai, Hiromichi</au><au>Sato, Yasunori</au><au>Isono, Shiroh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of opioids on respiration assessed by a contact-free unconstraint respiratory monitor with load cells under the bed in patients with advanced cancer</atitle><jtitle>Journal of applied physiology (1985)</jtitle><date>2021-06-01</date><risdate>2021</risdate><volume>130</volume><issue>6</issue><spage>1743</spage><epage>1753</epage><pages>1743-1753</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><abstract>Through usage of a novel contact-free unconstraint vital sign monitoring system with four load cells placed under the bed legs allowing continuous measurements of respiratory changes of center of gravity on the bed, this study is the first to assess detailed respiratory characteristics throughout day and night periods without interference of daily activities in patients with advanced cancer receiving opioids. Respiratory rhythm irregularity is a predominant specific feature of opioid dose-dependent respiratory depression particularly in female patients with advanced cancer.
Nocturnal periodic breathing of chronic opioid users has been predominantly documented by the use of polysomnography. No previous studies have assessed the opioid effects of respiratory rhythms throughout the day without the use of physical restraint. We recently developed a contact-free unconstraint vital sign monitoring system with four load cells placed under the bed legs, which allows continuous measurements of respiratory change at the center of gravity on the bed. We aimed to reveal details of the patient’s 24-h respiratory status under a monitoring system and to test the hypothesis that respiratory rhythm abnormalities are opioid dose-dependent and worsen during the night time. Continuous 48-h respiratory measurements were successfully performed in 51 patients with advanced cancer (12 opioid-free patients and 39 opioid-receiving patients). Medians of respiratory variables with minimal body movement artifacts were calculated for each 8-h split time period. Compared with opioid-free patients, opioid-receiving patients had slower respiratory rate with higher respiratory rate irregularity without changing tidal centroid shift regardless of the time period. Irregular ataxic breathing was only identified in opioid-receiving patients (33%, P = 0.023) whereas incidence rate of periodic breathing did not differ between the groups. Multivariate regression analyses revealed that opioid dose was an independent risk factor for occurrence of irregular breathing [odds ratio 1.81 (95% CI: 1.39–2.36), P < 0.001], and ataxic breathing [odds ratio 2.08 (95% CI: 1.60–2.71), P < 0.001]. Females developed the ataxic breathing at lower opioid dose compared with males. We conclude that respiratory rhythm irregularity is a predominant specific feature of opioid dose-dependent respiratory depression particularly in female patients with advanced cancer.
NEW & NOTEWORTHY Through usage of a novel contact-free unconstraint vital sign monitoring system with four load cells placed under the bed legs allowing continuous measurements of respiratory changes of center of gravity on the bed, this study is the first to assess detailed respiratory characteristics throughout day and night periods without interference of daily activities in patients with advanced cancer receiving opioids. Respiratory rhythm irregularity is a predominant specific feature of opioid dose-dependent respiratory depression particularly in female patients with advanced cancer.</abstract><cop>Bethesda</cop><pub>American Physiological Society</pub><doi>10.1152/japplphysiol.00904.2020</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-1875-6098</orcidid></addata></record> |
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| source | American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Abnormalities Bed load Breathing Cancer Center of gravity Centroids Irregularities Load cells Monitoring Monitoring systems Narcotics Opioids Respiration Respiratory rate Rhythm Risk analysis Risk factors |
| title | Effects of opioids on respiration assessed by a contact-free unconstraint respiratory monitor with load cells under the bed in patients with advanced cancer |
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