Identification of skin aging biomarkers correlated with the biomechanical properties
Background Skin aging can be described as a combination of intrinsic and extrinsic aging. Various parameters for evaluating skin characteristics have been proposed. However, an accurate biomarker for skin aging and the relationship between biomarkers and biomechanical parameters of the skin is yet t...
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| Veröffentlicht in: | Skin research and technology 2021-09, Vol.27 (5), p.940-947 |
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| creator | Kim, Seo Hyeong Kim, Ji Hye Suk, Jang Mi Lee, Young In Kim, Jihee Lee, Ju Hee Lee, Kwang Hoon |
| description | Background
Skin aging can be described as a combination of intrinsic and extrinsic aging. Various parameters for evaluating skin characteristics have been proposed. However, an accurate biomarker for skin aging and the relationship between biomarkers and biomechanical parameters of the skin is yet to be explored.
Materials and Methods
This study included 20 subjects by age. Skin aging was measured using non‐invasive devices. Skin tissues were acquired through punch biopsy for immunohistochemistry and qRT‐PCR of skin aging biomarkers, and analyzed correlation both, validated their use.
Results
Biomechanical properties of skin aging decreased with age. Among the biomarkers previously reported, we found that the expression of Moesin, TXNDC5, RhoGDI, and RSU1 decreased, while that of Vimentin and FABP5 increased with age. Pearson correlation showed that the expression levels of TXNDC5, RhoGDI, RSU1, and Vimentin were significantly correlated with the results of non‐invasive measurements. In addition, the expression of TXNDC5, RhoGDI, and RSU1 increased, while that of Vimentin decreased, in skin explants upon treatment with one of the anti‐aging compounds, retinoic acid.
Conclusion
From this study, we identified practical molecular biomarkers of skin aging, TXNDC5, RhoGDI, RSU1, and Vimentin, which correlated with the skin biomechanical properties of skin aging. |
| doi_str_mv | 10.1111/srt.13046 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_proquest_miscellaneous_2518221057</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2583278926</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3536-a4319726d72903d86b8e7aaabacfcf2330e6a8b732084292ad48192809bad91e3</originalsourceid><addsrcrecordid>eNp1kF1LwzAUhoMobk4v_ANS8EYv6vKxpsmlDD8GA0EneBfS9HTL1rUzaRn798Z1eiF4bnIgT95z8iB0SfAdCTX0rrkjDI_4EeoTjnGMxYgfoz6WWMZpQj966Mz7JcY4kYSdoh5jIjSM99FskkPV2MIa3di6iuoi8itbRXpuq3mU2Xqt3Qqcj0ztHJS6gTza2mYRNQvYX4NZ6Cq8LqONqzfgGgv-HJ0UuvRwcTgH6P3xYTZ-jqcvT5Px_TQ2LGE81iNGZEp5nlKJWS54JiDVWmfaFKagjGHgWmQpo-E_VFKdjwSRVGCZ6VwSYAN00-WG0Z8t-EatrTdQlrqCuvWKJkRQSnCSBvT6D7qsW1eF7QIlGE2FpDxQtx1lXO29g0JtnA0Gdopg9a1aBdVqrzqwV4fENltD_kv-uA3AsAO2toTd_0nq7XXWRX4BNhuIFw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2583278926</pqid></control><display><type>article</type><title>Identification of skin aging biomarkers correlated with the biomechanical properties</title><source>Wiley Online Library Open Access</source><creator>Kim, Seo Hyeong ; Kim, Ji Hye ; Suk, Jang Mi ; Lee, Young In ; Kim, Jihee ; Lee, Ju Hee ; Lee, Kwang Hoon</creator><creatorcontrib>Kim, Seo Hyeong ; Kim, Ji Hye ; Suk, Jang Mi ; Lee, Young In ; Kim, Jihee ; Lee, Ju Hee ; Lee, Kwang Hoon</creatorcontrib><description>Background
Skin aging can be described as a combination of intrinsic and extrinsic aging. Various parameters for evaluating skin characteristics have been proposed. However, an accurate biomarker for skin aging and the relationship between biomarkers and biomechanical parameters of the skin is yet to be explored.
Materials and Methods
This study included 20 subjects by age. Skin aging was measured using non‐invasive devices. Skin tissues were acquired through punch biopsy for immunohistochemistry and qRT‐PCR of skin aging biomarkers, and analyzed correlation both, validated their use.
Results
Biomechanical properties of skin aging decreased with age. Among the biomarkers previously reported, we found that the expression of Moesin, TXNDC5, RhoGDI, and RSU1 decreased, while that of Vimentin and FABP5 increased with age. Pearson correlation showed that the expression levels of TXNDC5, RhoGDI, RSU1, and Vimentin were significantly correlated with the results of non‐invasive measurements. In addition, the expression of TXNDC5, RhoGDI, and RSU1 increased, while that of Vimentin decreased, in skin explants upon treatment with one of the anti‐aging compounds, retinoic acid.
Conclusion
From this study, we identified practical molecular biomarkers of skin aging, TXNDC5, RhoGDI, RSU1, and Vimentin, which correlated with the skin biomechanical properties of skin aging.</description><identifier>ISSN: 0909-752X</identifier><identifier>EISSN: 1600-0846</identifier><identifier>DOI: 10.1111/srt.13046</identifier><identifier>PMID: 33891336</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Age ; Aging ; Biomarkers ; biomechanical properties ; Biomechanics ; Biopsy ; Explants ; Immunohistochemistry ; Mechanical properties ; Moesin ; Parameters ; Retinoic acid ; RhoGDI ; RSU1 ; Skin ; skin aging ; TXNDC5 ; Vimentin</subject><ispartof>Skin research and technology, 2021-09, Vol.27 (5), p.940-947</ispartof><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2021 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-a4319726d72903d86b8e7aaabacfcf2330e6a8b732084292ad48192809bad91e3</citedby><cites>FETCH-LOGICAL-c3536-a4319726d72903d86b8e7aaabacfcf2330e6a8b732084292ad48192809bad91e3</cites><orcidid>0000-0002-3720-2509</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fsrt.13046$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fsrt.13046$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,11542,27903,27904,45553,45554,46031,46455</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fsrt.13046$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33891336$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Seo Hyeong</creatorcontrib><creatorcontrib>Kim, Ji Hye</creatorcontrib><creatorcontrib>Suk, Jang Mi</creatorcontrib><creatorcontrib>Lee, Young In</creatorcontrib><creatorcontrib>Kim, Jihee</creatorcontrib><creatorcontrib>Lee, Ju Hee</creatorcontrib><creatorcontrib>Lee, Kwang Hoon</creatorcontrib><title>Identification of skin aging biomarkers correlated with the biomechanical properties</title><title>Skin research and technology</title><addtitle>Skin Res Technol</addtitle><description>Background
Skin aging can be described as a combination of intrinsic and extrinsic aging. Various parameters for evaluating skin characteristics have been proposed. However, an accurate biomarker for skin aging and the relationship between biomarkers and biomechanical parameters of the skin is yet to be explored.
Materials and Methods
This study included 20 subjects by age. Skin aging was measured using non‐invasive devices. Skin tissues were acquired through punch biopsy for immunohistochemistry and qRT‐PCR of skin aging biomarkers, and analyzed correlation both, validated their use.
Results
Biomechanical properties of skin aging decreased with age. Among the biomarkers previously reported, we found that the expression of Moesin, TXNDC5, RhoGDI, and RSU1 decreased, while that of Vimentin and FABP5 increased with age. Pearson correlation showed that the expression levels of TXNDC5, RhoGDI, RSU1, and Vimentin were significantly correlated with the results of non‐invasive measurements. In addition, the expression of TXNDC5, RhoGDI, and RSU1 increased, while that of Vimentin decreased, in skin explants upon treatment with one of the anti‐aging compounds, retinoic acid.
Conclusion
From this study, we identified practical molecular biomarkers of skin aging, TXNDC5, RhoGDI, RSU1, and Vimentin, which correlated with the skin biomechanical properties of skin aging.</description><subject>Age</subject><subject>Aging</subject><subject>Biomarkers</subject><subject>biomechanical properties</subject><subject>Biomechanics</subject><subject>Biopsy</subject><subject>Explants</subject><subject>Immunohistochemistry</subject><subject>Mechanical properties</subject><subject>Moesin</subject><subject>Parameters</subject><subject>Retinoic acid</subject><subject>RhoGDI</subject><subject>RSU1</subject><subject>Skin</subject><subject>skin aging</subject><subject>TXNDC5</subject><subject>Vimentin</subject><issn>0909-752X</issn><issn>1600-0846</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kF1LwzAUhoMobk4v_ANS8EYv6vKxpsmlDD8GA0EneBfS9HTL1rUzaRn798Z1eiF4bnIgT95z8iB0SfAdCTX0rrkjDI_4EeoTjnGMxYgfoz6WWMZpQj966Mz7JcY4kYSdoh5jIjSM99FskkPV2MIa3di6iuoi8itbRXpuq3mU2Xqt3Qqcj0ztHJS6gTza2mYRNQvYX4NZ6Cq8LqONqzfgGgv-HJ0UuvRwcTgH6P3xYTZ-jqcvT5Px_TQ2LGE81iNGZEp5nlKJWS54JiDVWmfaFKagjGHgWmQpo-E_VFKdjwSRVGCZ6VwSYAN00-WG0Z8t-EatrTdQlrqCuvWKJkRQSnCSBvT6D7qsW1eF7QIlGE2FpDxQtx1lXO29g0JtnA0Gdopg9a1aBdVqrzqwV4fENltD_kv-uA3AsAO2toTd_0nq7XXWRX4BNhuIFw</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Kim, Seo Hyeong</creator><creator>Kim, Ji Hye</creator><creator>Suk, Jang Mi</creator><creator>Lee, Young In</creator><creator>Kim, Jihee</creator><creator>Lee, Ju Hee</creator><creator>Lee, Kwang Hoon</creator><general>John Wiley & Sons, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3720-2509</orcidid></search><sort><creationdate>202109</creationdate><title>Identification of skin aging biomarkers correlated with the biomechanical properties</title><author>Kim, Seo Hyeong ; Kim, Ji Hye ; Suk, Jang Mi ; Lee, Young In ; Kim, Jihee ; Lee, Ju Hee ; Lee, Kwang Hoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-a4319726d72903d86b8e7aaabacfcf2330e6a8b732084292ad48192809bad91e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Aging</topic><topic>Biomarkers</topic><topic>biomechanical properties</topic><topic>Biomechanics</topic><topic>Biopsy</topic><topic>Explants</topic><topic>Immunohistochemistry</topic><topic>Mechanical properties</topic><topic>Moesin</topic><topic>Parameters</topic><topic>Retinoic acid</topic><topic>RhoGDI</topic><topic>RSU1</topic><topic>Skin</topic><topic>skin aging</topic><topic>TXNDC5</topic><topic>Vimentin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Seo Hyeong</creatorcontrib><creatorcontrib>Kim, Ji Hye</creatorcontrib><creatorcontrib>Suk, Jang Mi</creatorcontrib><creatorcontrib>Lee, Young In</creatorcontrib><creatorcontrib>Kim, Jihee</creatorcontrib><creatorcontrib>Lee, Ju Hee</creatorcontrib><creatorcontrib>Lee, Kwang Hoon</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Skin research and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Kim, Seo Hyeong</au><au>Kim, Ji Hye</au><au>Suk, Jang Mi</au><au>Lee, Young In</au><au>Kim, Jihee</au><au>Lee, Ju Hee</au><au>Lee, Kwang Hoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of skin aging biomarkers correlated with the biomechanical properties</atitle><jtitle>Skin research and technology</jtitle><addtitle>Skin Res Technol</addtitle><date>2021-09</date><risdate>2021</risdate><volume>27</volume><issue>5</issue><spage>940</spage><epage>947</epage><pages>940-947</pages><issn>0909-752X</issn><eissn>1600-0846</eissn><abstract>Background
Skin aging can be described as a combination of intrinsic and extrinsic aging. Various parameters for evaluating skin characteristics have been proposed. However, an accurate biomarker for skin aging and the relationship between biomarkers and biomechanical parameters of the skin is yet to be explored.
Materials and Methods
This study included 20 subjects by age. Skin aging was measured using non‐invasive devices. Skin tissues were acquired through punch biopsy for immunohistochemistry and qRT‐PCR of skin aging biomarkers, and analyzed correlation both, validated their use.
Results
Biomechanical properties of skin aging decreased with age. Among the biomarkers previously reported, we found that the expression of Moesin, TXNDC5, RhoGDI, and RSU1 decreased, while that of Vimentin and FABP5 increased with age. Pearson correlation showed that the expression levels of TXNDC5, RhoGDI, RSU1, and Vimentin were significantly correlated with the results of non‐invasive measurements. In addition, the expression of TXNDC5, RhoGDI, and RSU1 increased, while that of Vimentin decreased, in skin explants upon treatment with one of the anti‐aging compounds, retinoic acid.
Conclusion
From this study, we identified practical molecular biomarkers of skin aging, TXNDC5, RhoGDI, RSU1, and Vimentin, which correlated with the skin biomechanical properties of skin aging.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>33891336</pmid><doi>10.1111/srt.13046</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3720-2509</orcidid></addata></record> |
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| subjects | Age Aging Biomarkers biomechanical properties Biomechanics Biopsy Explants Immunohistochemistry Mechanical properties Moesin Parameters Retinoic acid RhoGDI RSU1 Skin skin aging TXNDC5 Vimentin |
| title | Identification of skin aging biomarkers correlated with the biomechanical properties |
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