Core Temperature Lability Predicts Sympathetic Interruption and Cognitive Performance during Heat Exposure in Persons with Spinal Cord Injuries
Among persons with high spinal cord injury (Hi-SCI: > T5), changes in core body temperature (Tcore) and cognitive performance during heat exposure appear related to degree of sympathetic interruption. Twenty men with Hi-SCI (C4-T4, American Spinal Injury Association Impairment Scale [AIS] A-B) an...
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| Veröffentlicht in: | Journal of neurotrauma 2021-08, Vol.38 (15), p.2141-2150 |
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| creator | Kumar, Nina S Bart, Jessica Barton, Christian Graham, Marin L Leung, Patricia P Tittley, Tishina D Lee, Ingrid Bang, Charlene Bauman, William A Handrakis, John P |
| description | Among persons with high spinal cord injury (Hi-SCI: > T5), changes in core body temperature (Tcore) and cognitive performance during heat exposure appear related to degree of sympathetic interruption. Twenty men with Hi-SCI (C4-T4, American Spinal Injury Association Impairment Scale [AIS] A-B) and 19 matched, able-bodied controls were acclimated to 27°C baseline (BL) before exposure to 35°C heat challenge (HC). Two groups, differentiated by increase in Tcore during HC, were identified: high responders (HR-SCI: ΔTcore ≥0.5°C;
= 13, C4-T2) and low responders (LR-SCI: ΔTcore |
| doi_str_mv | 10.1089/neu.2020.7598 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2516840187</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2516840187</sourcerecordid><originalsourceid>FETCH-LOGICAL-c321t-884f2aac55a550873485ec68cc028b4ea667d1408211114df4bec05a5f23b2eb3</originalsourceid><addsrcrecordid>eNpdkU1LwzAYgIMoOqdHrxLw4qUzSZs2O8qYHzBwMD2XNH2rGW1Sk1Tdr_Avm-LHwVwSyPM-vPAgdEbJjBIxvzIwzBhhZFbwudhDE8p5kcxJxvbRJP4XSUE5PULH3m8JoWnOikN0lKZCsHwuJuhzYR3gR-h6cDIM8b2SlW512OG1g1qr4PFm1_UyvEDQCt-bAM4NfdDWYGlqvLDPRgf9BngNrrGuk0YBrgenzTO-Axnw8qO3fjRrMzLeGo_fdXjBm14b2UaDq6N3G0fAn6CDRrYeTn_uKXq6WT4u7pLVw-394nqVqJTRkAiRNUxKxbnknIgizQQHlQulCBNVBjLPi5pmRDAaT1Y3WQWKRLhhacWgSqfo8tvbO_s6gA9lp72CtpUG7OBLxmkuMkKjeoou_qFbO7i4-UjxCORM0Egl35Ry1nsHTdk73Um3Kykpx1JlLFWOpcqxVOTPf6xD1UH9R_-mSb8AAz2Q8Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2558736281</pqid></control><display><type>article</type><title>Core Temperature Lability Predicts Sympathetic Interruption and Cognitive Performance during Heat Exposure in Persons with Spinal Cord Injuries</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Kumar, Nina S ; Bart, Jessica ; Barton, Christian ; Graham, Marin L ; Leung, Patricia P ; Tittley, Tishina D ; Lee, Ingrid ; Bang, Charlene ; Bauman, William A ; Handrakis, John P</creator><creatorcontrib>Kumar, Nina S ; Bart, Jessica ; Barton, Christian ; Graham, Marin L ; Leung, Patricia P ; Tittley, Tishina D ; Lee, Ingrid ; Bang, Charlene ; Bauman, William A ; Handrakis, John P</creatorcontrib><description>Among persons with high spinal cord injury (Hi-SCI: > T5), changes in core body temperature (Tcore) and cognitive performance during heat exposure appear related to degree of sympathetic interruption. Twenty men with Hi-SCI (C4-T4, American Spinal Injury Association Impairment Scale [AIS] A-B) and 19 matched, able-bodied controls were acclimated to 27°C baseline (BL) before exposure to 35°C heat challenge (HC). Two groups, differentiated by increase in Tcore during HC, were identified: high responders (HR-SCI: ΔTcore ≥0.5°C;
= 13, C4-T2) and low responders (LR-SCI: ΔTcore <0.5°C;
= 7, C4-T4). Tcore, distal skin temperatures (Tsk
), and distal microvascular perfusion (LDF
) were measured, as were indices of sympathetic integrity, mean arterial pressure (MAP), and extremity sweat rate (SR
). Cognitive performance was assessed at BL and post-HC, using the Stroop Color and Word and Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) Digit Span tests. At BL, Tcore of the HR-SCI group (36.6 ± 0.4°C) was lower than that for the LR-SCI (37.1 ± 0.3°C;
= 0.011) and control groups (37.3 ± 0.3°C;
< 0.001). After HC, Tcore was not different among groups. MAP of the HR-SCI group (70.9 ± 9.8 mm Hg) was lower than that of the LR-SCI (81.8 ± 7.0 mm Hg;
= 0.048) and control groups (89.9 ± 9.9 mm Hg;
< 0.001). SR
increased more in the control group (77.0 ± 52.5 nL/cm
/min) than in the HR-SCI group (15.5 ± 22.0 nL/cm
/min;
= 0.001). Only the HR-SCI group had significant increases in T-Scores of Stroop Word (7.5 ± 4.4;
< 0.001), WAIS-IV Digit Span Sequence (1.9 ± 1.8;
= 0.002), and WAIS-IV Digit Span Total (1.4 ± 1.6;
= 0.008). Persons with SCI who responded to HC with a greater change in Tcore demonstrated evidence of greater sympathetic interruption and had an associated improvement in cognitive performance.</description><identifier>ISSN: 0897-7151</identifier><identifier>EISSN: 1557-9042</identifier><identifier>DOI: 10.1089/neu.2020.7598</identifier><identifier>PMID: 33882698</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adult ; Blood pressure ; Body temperature ; Body Temperature - physiology ; Case-Control Studies ; Cognition - physiology ; Cognitive ability ; Cold ; Female ; Heat ; Hot Temperature ; Humans ; Injuries ; Intelligence ; Lability ; Male ; Microvasculature ; Middle Aged ; Paralysis ; Perfusion ; Predictive Value of Tests ; Risk Factors ; Skin ; Spinal cord injuries ; Spinal Cord Injuries - physiopathology ; Spinal Cord Injuries - psychology ; Sympathetic Nervous System - physiopathology ; Variance analysis</subject><ispartof>Journal of neurotrauma, 2021-08, Vol.38 (15), p.2141-2150</ispartof><rights>Copyright Mary Ann Liebert, Inc. Aug 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-884f2aac55a550873485ec68cc028b4ea667d1408211114df4bec05a5f23b2eb3</citedby><cites>FETCH-LOGICAL-c321t-884f2aac55a550873485ec68cc028b4ea667d1408211114df4bec05a5f23b2eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33882698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumar, Nina S</creatorcontrib><creatorcontrib>Bart, Jessica</creatorcontrib><creatorcontrib>Barton, Christian</creatorcontrib><creatorcontrib>Graham, Marin L</creatorcontrib><creatorcontrib>Leung, Patricia P</creatorcontrib><creatorcontrib>Tittley, Tishina D</creatorcontrib><creatorcontrib>Lee, Ingrid</creatorcontrib><creatorcontrib>Bang, Charlene</creatorcontrib><creatorcontrib>Bauman, William A</creatorcontrib><creatorcontrib>Handrakis, John P</creatorcontrib><title>Core Temperature Lability Predicts Sympathetic Interruption and Cognitive Performance during Heat Exposure in Persons with Spinal Cord Injuries</title><title>Journal of neurotrauma</title><addtitle>J Neurotrauma</addtitle><description>Among persons with high spinal cord injury (Hi-SCI: > T5), changes in core body temperature (Tcore) and cognitive performance during heat exposure appear related to degree of sympathetic interruption. Twenty men with Hi-SCI (C4-T4, American Spinal Injury Association Impairment Scale [AIS] A-B) and 19 matched, able-bodied controls were acclimated to 27°C baseline (BL) before exposure to 35°C heat challenge (HC). Two groups, differentiated by increase in Tcore during HC, were identified: high responders (HR-SCI: ΔTcore ≥0.5°C;
= 13, C4-T2) and low responders (LR-SCI: ΔTcore <0.5°C;
= 7, C4-T4). Tcore, distal skin temperatures (Tsk
), and distal microvascular perfusion (LDF
) were measured, as were indices of sympathetic integrity, mean arterial pressure (MAP), and extremity sweat rate (SR
). Cognitive performance was assessed at BL and post-HC, using the Stroop Color and Word and Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) Digit Span tests. At BL, Tcore of the HR-SCI group (36.6 ± 0.4°C) was lower than that for the LR-SCI (37.1 ± 0.3°C;
= 0.011) and control groups (37.3 ± 0.3°C;
< 0.001). After HC, Tcore was not different among groups. MAP of the HR-SCI group (70.9 ± 9.8 mm Hg) was lower than that of the LR-SCI (81.8 ± 7.0 mm Hg;
= 0.048) and control groups (89.9 ± 9.9 mm Hg;
< 0.001). SR
increased more in the control group (77.0 ± 52.5 nL/cm
/min) than in the HR-SCI group (15.5 ± 22.0 nL/cm
/min;
= 0.001). Only the HR-SCI group had significant increases in T-Scores of Stroop Word (7.5 ± 4.4;
< 0.001), WAIS-IV Digit Span Sequence (1.9 ± 1.8;
= 0.002), and WAIS-IV Digit Span Total (1.4 ± 1.6;
= 0.008). Persons with SCI who responded to HC with a greater change in Tcore demonstrated evidence of greater sympathetic interruption and had an associated improvement in cognitive performance.</description><subject>Adult</subject><subject>Blood pressure</subject><subject>Body temperature</subject><subject>Body Temperature - physiology</subject><subject>Case-Control Studies</subject><subject>Cognition - physiology</subject><subject>Cognitive ability</subject><subject>Cold</subject><subject>Female</subject><subject>Heat</subject><subject>Hot Temperature</subject><subject>Humans</subject><subject>Injuries</subject><subject>Intelligence</subject><subject>Lability</subject><subject>Male</subject><subject>Microvasculature</subject><subject>Middle Aged</subject><subject>Paralysis</subject><subject>Perfusion</subject><subject>Predictive Value of Tests</subject><subject>Risk Factors</subject><subject>Skin</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - physiopathology</subject><subject>Spinal Cord Injuries - psychology</subject><subject>Sympathetic Nervous System - physiopathology</subject><subject>Variance analysis</subject><issn>0897-7151</issn><issn>1557-9042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1LwzAYgIMoOqdHrxLw4qUzSZs2O8qYHzBwMD2XNH2rGW1Sk1Tdr_Avm-LHwVwSyPM-vPAgdEbJjBIxvzIwzBhhZFbwudhDE8p5kcxJxvbRJP4XSUE5PULH3m8JoWnOikN0lKZCsHwuJuhzYR3gR-h6cDIM8b2SlW512OG1g1qr4PFm1_UyvEDQCt-bAM4NfdDWYGlqvLDPRgf9BngNrrGuk0YBrgenzTO-Axnw8qO3fjRrMzLeGo_fdXjBm14b2UaDq6N3G0fAn6CDRrYeTn_uKXq6WT4u7pLVw-394nqVqJTRkAiRNUxKxbnknIgizQQHlQulCBNVBjLPi5pmRDAaT1Y3WQWKRLhhacWgSqfo8tvbO_s6gA9lp72CtpUG7OBLxmkuMkKjeoou_qFbO7i4-UjxCORM0Egl35Ry1nsHTdk73Um3Kykpx1JlLFWOpcqxVOTPf6xD1UH9R_-mSb8AAz2Q8Q</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Kumar, Nina S</creator><creator>Bart, Jessica</creator><creator>Barton, Christian</creator><creator>Graham, Marin L</creator><creator>Leung, Patricia P</creator><creator>Tittley, Tishina D</creator><creator>Lee, Ingrid</creator><creator>Bang, Charlene</creator><creator>Bauman, William A</creator><creator>Handrakis, John P</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20210801</creationdate><title>Core Temperature Lability Predicts Sympathetic Interruption and Cognitive Performance during Heat Exposure in Persons with Spinal Cord Injuries</title><author>Kumar, Nina S ; Bart, Jessica ; Barton, Christian ; Graham, Marin L ; Leung, Patricia P ; Tittley, Tishina D ; Lee, Ingrid ; Bang, Charlene ; Bauman, William A ; Handrakis, John P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-884f2aac55a550873485ec68cc028b4ea667d1408211114df4bec05a5f23b2eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Blood pressure</topic><topic>Body temperature</topic><topic>Body Temperature - physiology</topic><topic>Case-Control Studies</topic><topic>Cognition - physiology</topic><topic>Cognitive ability</topic><topic>Cold</topic><topic>Female</topic><topic>Heat</topic><topic>Hot Temperature</topic><topic>Humans</topic><topic>Injuries</topic><topic>Intelligence</topic><topic>Lability</topic><topic>Male</topic><topic>Microvasculature</topic><topic>Middle Aged</topic><topic>Paralysis</topic><topic>Perfusion</topic><topic>Predictive Value of Tests</topic><topic>Risk Factors</topic><topic>Skin</topic><topic>Spinal cord injuries</topic><topic>Spinal Cord Injuries - physiopathology</topic><topic>Spinal Cord Injuries - psychology</topic><topic>Sympathetic Nervous System - physiopathology</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumar, Nina S</creatorcontrib><creatorcontrib>Bart, Jessica</creatorcontrib><creatorcontrib>Barton, Christian</creatorcontrib><creatorcontrib>Graham, Marin L</creatorcontrib><creatorcontrib>Leung, Patricia P</creatorcontrib><creatorcontrib>Tittley, Tishina D</creatorcontrib><creatorcontrib>Lee, Ingrid</creatorcontrib><creatorcontrib>Bang, Charlene</creatorcontrib><creatorcontrib>Bauman, William A</creatorcontrib><creatorcontrib>Handrakis, John P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurotrauma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumar, Nina S</au><au>Bart, Jessica</au><au>Barton, Christian</au><au>Graham, Marin L</au><au>Leung, Patricia P</au><au>Tittley, Tishina D</au><au>Lee, Ingrid</au><au>Bang, Charlene</au><au>Bauman, William A</au><au>Handrakis, John P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Core Temperature Lability Predicts Sympathetic Interruption and Cognitive Performance during Heat Exposure in Persons with Spinal Cord Injuries</atitle><jtitle>Journal of neurotrauma</jtitle><addtitle>J Neurotrauma</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>38</volume><issue>15</issue><spage>2141</spage><epage>2150</epage><pages>2141-2150</pages><issn>0897-7151</issn><eissn>1557-9042</eissn><abstract>Among persons with high spinal cord injury (Hi-SCI: > T5), changes in core body temperature (Tcore) and cognitive performance during heat exposure appear related to degree of sympathetic interruption. Twenty men with Hi-SCI (C4-T4, American Spinal Injury Association Impairment Scale [AIS] A-B) and 19 matched, able-bodied controls were acclimated to 27°C baseline (BL) before exposure to 35°C heat challenge (HC). Two groups, differentiated by increase in Tcore during HC, were identified: high responders (HR-SCI: ΔTcore ≥0.5°C;
= 13, C4-T2) and low responders (LR-SCI: ΔTcore <0.5°C;
= 7, C4-T4). Tcore, distal skin temperatures (Tsk
), and distal microvascular perfusion (LDF
) were measured, as were indices of sympathetic integrity, mean arterial pressure (MAP), and extremity sweat rate (SR
). Cognitive performance was assessed at BL and post-HC, using the Stroop Color and Word and Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) Digit Span tests. At BL, Tcore of the HR-SCI group (36.6 ± 0.4°C) was lower than that for the LR-SCI (37.1 ± 0.3°C;
= 0.011) and control groups (37.3 ± 0.3°C;
< 0.001). After HC, Tcore was not different among groups. MAP of the HR-SCI group (70.9 ± 9.8 mm Hg) was lower than that of the LR-SCI (81.8 ± 7.0 mm Hg;
= 0.048) and control groups (89.9 ± 9.9 mm Hg;
< 0.001). SR
increased more in the control group (77.0 ± 52.5 nL/cm
/min) than in the HR-SCI group (15.5 ± 22.0 nL/cm
/min;
= 0.001). Only the HR-SCI group had significant increases in T-Scores of Stroop Word (7.5 ± 4.4;
< 0.001), WAIS-IV Digit Span Sequence (1.9 ± 1.8;
= 0.002), and WAIS-IV Digit Span Total (1.4 ± 1.6;
= 0.008). Persons with SCI who responded to HC with a greater change in Tcore demonstrated evidence of greater sympathetic interruption and had an associated improvement in cognitive performance.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>33882698</pmid><doi>10.1089/neu.2020.7598</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Blood pressure Body temperature Body Temperature - physiology Case-Control Studies Cognition - physiology Cognitive ability Cold Female Heat Hot Temperature Humans Injuries Intelligence Lability Male Microvasculature Middle Aged Paralysis Perfusion Predictive Value of Tests Risk Factors Skin Spinal cord injuries Spinal Cord Injuries - physiopathology Spinal Cord Injuries - psychology Sympathetic Nervous System - physiopathology Variance analysis |
| title | Core Temperature Lability Predicts Sympathetic Interruption and Cognitive Performance during Heat Exposure in Persons with Spinal Cord Injuries |
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