Myrindole A, an Antimicrobial Bis-indole from a Marine Sponge Myrmekioderma sp
Myrindole A, a bis-indole alkaloid, was isolated from the deep-sea sponge Myrmekioderma sp. The high degree of unsaturation of the molecule complicated the assignment of its structure by standard 2D-NMR experiments but was ultimately achieved by a combination of 1H–15N-HMBC and 1,n-ADEQUATE experime...
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| Veröffentlicht in: | Organic letters 2021-05, Vol.23 (9), p.3477-3480 |
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| container_title | Organic letters |
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| creator | Moosmann, Philipp Taniguchi, Tohru Furihata, Kazuo Utsumi, Hiroaki Ise, Yuji Morii, Yasuhiro Yamawaki, Nobuhiro Takatani, Tomohiro Arakawa, Osamu Okada, Shigeru Matsunaga, Shigeki |
| description | Myrindole A, a bis-indole alkaloid, was isolated from the deep-sea sponge Myrmekioderma sp. The high degree of unsaturation of the molecule complicated the assignment of its structure by standard 2D-NMR experiments but was ultimately achieved by a combination of 1H–15N-HMBC and 1,n-ADEQUATE experiments as well as the comparison of measured and calculated CD spectra. Myrindole A showed antimicrobial activity against Gram-positive and Gram-negative bacteria. |
| doi_str_mv | 10.1021/acs.orglett.1c00922 |
| format | Article |
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| ispartof | Organic letters, 2021-05, Vol.23 (9), p.3477-3480 |
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| language | eng |
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| source | ACS Publications |
| title | Myrindole A, an Antimicrobial Bis-indole from a Marine Sponge Myrmekioderma sp |
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