Reactive oxygen species-responsive dendritic cell-derived exosomes for rheumatoid arthritis

Although tolerogenic dendritic cell-derived exosomes (TolDex) have emerged as promising therapeutics for rheumatoid arthritis (RA), their clinical applications have been hampered by their poor in vivo disposition after systemic administration. Herein, we report the development of stimuli-responsive...

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Veröffentlicht in:	Acta biomaterialia 2021-07, Vol.128, p.462-473
Hauptverfasser:	Lee, Eun Sook, Sul, Jae Hoon, Shin, Jung Min, Shin, Sol, Lee, Jae Ah, Kim, Hark Kyun, Cho, Yongeun, Ko, Hyewon, Son, Soyoung, Lee, Jeongmi, Park, Sunyoung, Jo, Dong-Gyu, Park, Jae Hyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis Blood circulation CD25 antigen CD4 antigen CD40 antigen Chemical compounds Collagen Cytokines Dendritic cells Dendritic structure Exosome Exosomes Foxp3 protein Growth factors Hydrophobicity Immune system Immunoregulation Inflammation Interleukin 6 Intravenous administration Joint diseases Lymphocytes Lymphocytes T Microenvironments Pharmacology Polyethylene glycol Reactive oxygen species Rheumatoid arthritis ROS-responsive Surface modification Transforming growth factor-b Tumor necrosis factor-TNF Tumor necrosis factor-α
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