KLa(0.95−x)GdxF4:Eu3+ hexagonal phase nanoparticles as luminescent probes for in vitro Huh-7 cancer cell imaging
A facile chemical route is reported for synthesizing red-emitting photoluminescent/MRI multi-functional KLa(0.95−x)GdxF4:Eu3+ (x = 0 to 0.4) bio-compatible nanomaterials for targeted in vitro tumor imaging. Hexagonal phase pure nanoparticles show a significant and systematic change in morphology wit...
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| Veröffentlicht in: | Dalton transactions : an international journal of inorganic chemistry 2021-04, Vol.50 (15), p.5197-5207 |
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| container_end_page | 5207 |
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| container_issue | 15 |
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| container_title | Dalton transactions : an international journal of inorganic chemistry |
| container_volume | 50 |
| creator | Gupta, Mohini Nagarajan, Rajamani Ramamurthy, Chitteti Vivekanandan, Perumal G Vijaya Prakash |
| description | A facile chemical route is reported for synthesizing red-emitting photoluminescent/MRI multi-functional KLa(0.95−x)GdxF4:Eu3+ (x = 0 to 0.4) bio-compatible nanomaterials for targeted in vitro tumor imaging. Hexagonal phase pure nanoparticles show a significant and systematic change in morphology with enhanced photoluminescence due to the substitution of La3+ with Gd3+ ions. Single phase β-KLa(0.95−x)GdxF4:Eu3+ exhibits multifunctional properties, both intense red emission and strong paramagnetism for high-contrast bioimaging applications. These silica capped magnetic/luminescent nanoparticles show long-term colloidal stability, optical transparency in water, strong red emission, and low cytotoxicity. The cellular uptake of coated nanoparticles was investigated in liver cancer cell line Huh-7. Our findings suggest that these nanoparticles can serve as highly luminescent imaging probes for in vitro applications with potential for in vivo and live cell imaging applications. |
| doi_str_mv | 10.1039/d1dt00539a |
| format | Article |
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| identifier | ISSN: 1477-9226 |
| ispartof | Dalton transactions : an international journal of inorganic chemistry, 2021-04, Vol.50 (15), p.5197-5207 |
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| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biocompatibility Chemical synthesis Emission analysis Emission spectra Europium Gadolinium Hexagonal phase Medical imaging Morphology Nanomaterials Nanoparticles Paramagnetism Photoluminescence Silicon dioxide Toxicity |
| title | KLa(0.95−x)GdxF4:Eu3+ hexagonal phase nanoparticles as luminescent probes for in vitro Huh-7 cancer cell imaging |
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