Palladium-Catalyzed Decarbonylative Sonogashira Coupling of Terminal Alkynes with Carboxylic Acids

Palladium-Catalyzed Decarbonylative Sonogashira Coupling of Terminal Alkynes with Carboxylic Acids

A direct decarbonylative Sonogashira coupling of terminal alkynes with carboxylic acids was achieved through palladium catalysis. This reaction did not use overstoichiometric oxidants, thus overcoming the homocoupling issue of terminal alkynes. Under the reaction conditions, a wide range of carboxyl...

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Veröffentlicht in:Organic letters 2021-05, Vol.23 (9), p.3304-3309
Hauptverfasser: Li, Xinyi, Liu, Long, Huang, Tianzeng, Tang, Zhi, Li, Chunya, Li, Wenhui, Zhang, Tao, Li, Zhaohui, Chen, Tieqiao
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container_end_page 3309
container_issue 9
container_start_page 3304
container_title Organic letters
container_volume 23
creator Li, Xinyi
Liu, Long
Huang, Tianzeng
Tang, Zhi
Li, Chunya
Li, Wenhui
Zhang, Tao
Li, Zhaohui
Chen, Tieqiao
description A direct decarbonylative Sonogashira coupling of terminal alkynes with carboxylic acids was achieved through palladium catalysis. This reaction did not use overstoichiometric oxidants, thus overcoming the homocoupling issue of terminal alkynes. Under the reaction conditions, a wide range of carboxylic acids including those bioactive ones could couple readily with various terminal alkynes, thus providing a relative general method for preparing internal alkynes.
doi_str_mv 10.1021/acs.orglett.1c00768
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title Palladium-Catalyzed Decarbonylative Sonogashira Coupling of Terminal Alkynes with Carboxylic Acids
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