Dual inhibition of MEK1/2 and MEK5 suppresses the EMT/migration axis in triple‐negative breast cancer through FRA‐1 regulation

Triple‐negative breast cancer (TNBC) presents a clinical challenge due to the aggressive nature of the disease and a lack of targeted therapies. Constitutive activation of the mitogen‐activated protein kinase (MAPK)/extracellular signal‐regulated kinase (ERK) pathway has been linked to chemoresistan...

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Veröffentlicht in:	Journal of cellular biochemistry 2021-08, Vol.122 (8), p.835-850
Hauptverfasser:	Hoang, Van T., Matossian, Margarite D., La, Jacqueline, Hoang, Kristine, Ucar, Deniz A., Elliott, Steven, Burks, Hope E., Wright, Thomas D., Patel, Saloni, Bhatt, Akshita, Phamduy, Theresa, Chrisey, Douglas, Buechlein, Aaron, Rusch, Douglas B., Nephew, Kenneth P., Anbalagan, Murali, Rowan, Brian, Cavanaugh, Jane E., Flaherty, Patrick T., Miele, Lucio, Collins‐Burow, Bridgette M., Burow, Matthew E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antitumor agents Breast cancer Breast carcinoma Chemoresistance Colon E-cadherin epithelial‐mesenchymal transition ERK5 Extracellular signal-regulated kinase Inhibitors Invasiveness Kinases MAP kinase MAP2K7 Markers MEK inhibitors Mesenchyme Metabolic pathways Metastases Metastasis patient‐derived xenograft Phenotypes Prostate Protein kinase Regulatory agencies Signal transduction Signaling targeted inhibitor Toxicity triple negative breast neoplasms
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