Synthesis of difluoromethylated diarylmethanes via Fe(OTf) 3 -catalyzed Friedel-Crafts reaction of 2,2-difluoro-1-arylethyl phosphates
The Fe(OTf) -catalyzed Friedel-Crafts reaction of 2,2-difluoro-1-arylethyl phosphates with electron-rich (hetero)arenes afforded difluoromethylated diarylmethanes. Control experiments showed that Fe(OTf) behaves as the Lewis acid, and that the phosphate leaving group and o- or p-alkoxy substituents...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2021-04, Vol.57 (32), p.3877-3880 |
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| container_issue | 32 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Yamamoto, Yoshihiko Takase, Tomoya Kuroyanagi, Eisuke Yasui, Takeshi |
| description | The Fe(OTf)
-catalyzed Friedel-Crafts reaction of 2,2-difluoro-1-arylethyl phosphates with electron-rich (hetero)arenes afforded difluoromethylated diarylmethanes. Control experiments showed that Fe(OTf)
behaves as the Lewis acid, and that the phosphate leaving group and o- or p-alkoxy substituents on the substrates are necessary for the Fe(OTf)
-catalyzed reaction to proceed under mild conditions. |
| doi_str_mv | 10.1039/d1cc00765c |
| format | Article |
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| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2021-04, Vol.57 (32), p.3877-3880 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Aromatic compounds Friedel-Crafts reaction Lewis acid NMR Nuclear magnetic resonance Phosphates Substrates |
| title | Synthesis of difluoromethylated diarylmethanes via Fe(OTf) 3 -catalyzed Friedel-Crafts reaction of 2,2-difluoro-1-arylethyl phosphates |
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