Synergistic activity of diclofenac sodium with oxacillin against planktonic cells and biofilm of methicillin-resistant Staphylococcus aureus strains
To evaluate the activity of diclofenac sodium and synergism with oxacillin against clinical strains of SARM in plactonic cells, antibiofilm and biofilm. Synergism activity was assessed using the fractional inhibitory concentration index and its possible mechanism of action by flow cytometry. The syn...
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| Veröffentlicht in: | Future microbiology 2021-04, Vol.16 (6), p.375-387 |
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| creator | Queiroz, Helaine A da Silva, Cecília R de Andrade Neto, João B do Av Sá, Lívia G do Nascimento, Francisca Bsa Moreno, Leticia Ss Barroso, Fátima Dd da Silva, Lisandra J Cândido, Thiago M de Oliveira, Leilson C de Mesquita, Jacó Rl de Moraes, Manoel O Cavalcanti, Bruno C Nobre Júnior, Hélio V |
| description | To evaluate the activity of diclofenac sodium and synergism with oxacillin against clinical strains of SARM in plactonic cells, antibiofilm and biofilm.
Synergism activity was assessed using the fractional inhibitory concentration index and its possible mechanism of action by flow cytometry.
The synergistic activity of diclofenac sodium with oxacillin was observed against plactonic cells, antibiofilm and in biofilm formed from clinical methicillin-resistant
strains.
This combination caused damage to the integrity of the membrane and ruptures in the DNA of the cells, leading to apoptosis. |
| doi_str_mv | 10.2217/fmb-2020-0095 |
| format | Article |
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Synergism activity was assessed using the fractional inhibitory concentration index and its possible mechanism of action by flow cytometry.
The synergistic activity of diclofenac sodium with oxacillin was observed against plactonic cells, antibiofilm and in biofilm formed from clinical methicillin-resistant
strains.
This combination caused damage to the integrity of the membrane and ruptures in the DNA of the cells, leading to apoptosis.</description><identifier>ISSN: 1746-0913</identifier><identifier>EISSN: 1746-0921</identifier><identifier>DOI: 10.2217/fmb-2020-0095</identifier><identifier>PMID: 33870731</identifier><language>eng</language><publisher>England</publisher><ispartof>Future microbiology, 2021-04, Vol.16 (6), p.375-387</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c293t-239ceaa45e23fda61c6a45cc76b9753e18be159eb331a641a93b049434d106283</citedby><cites>FETCH-LOGICAL-c293t-239ceaa45e23fda61c6a45cc76b9753e18be159eb331a641a93b049434d106283</cites><orcidid>0000-0002-0619-2782</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33870731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Queiroz, Helaine A</creatorcontrib><creatorcontrib>da Silva, Cecília R</creatorcontrib><creatorcontrib>de Andrade Neto, João B</creatorcontrib><creatorcontrib>do Av Sá, Lívia G</creatorcontrib><creatorcontrib>do Nascimento, Francisca Bsa</creatorcontrib><creatorcontrib>Moreno, Leticia Ss</creatorcontrib><creatorcontrib>Barroso, Fátima Dd</creatorcontrib><creatorcontrib>da Silva, Lisandra J</creatorcontrib><creatorcontrib>Cândido, Thiago M</creatorcontrib><creatorcontrib>de Oliveira, Leilson C</creatorcontrib><creatorcontrib>de Mesquita, Jacó Rl</creatorcontrib><creatorcontrib>de Moraes, Manoel O</creatorcontrib><creatorcontrib>Cavalcanti, Bruno C</creatorcontrib><creatorcontrib>Nobre Júnior, Hélio V</creatorcontrib><title>Synergistic activity of diclofenac sodium with oxacillin against planktonic cells and biofilm of methicillin-resistant Staphylococcus aureus strains</title><title>Future microbiology</title><addtitle>Future Microbiol</addtitle><description>To evaluate the activity of diclofenac sodium and synergism with oxacillin against clinical strains of SARM in plactonic cells, antibiofilm and biofilm.
Synergism activity was assessed using the fractional inhibitory concentration index and its possible mechanism of action by flow cytometry.
The synergistic activity of diclofenac sodium with oxacillin was observed against plactonic cells, antibiofilm and in biofilm formed from clinical methicillin-resistant
strains.
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Synergism activity was assessed using the fractional inhibitory concentration index and its possible mechanism of action by flow cytometry.
The synergistic activity of diclofenac sodium with oxacillin was observed against plactonic cells, antibiofilm and in biofilm formed from clinical methicillin-resistant
strains.
This combination caused damage to the integrity of the membrane and ruptures in the DNA of the cells, leading to apoptosis.</abstract><cop>England</cop><pmid>33870731</pmid><doi>10.2217/fmb-2020-0095</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-0619-2782</orcidid></addata></record> |
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| title | Synergistic activity of diclofenac sodium with oxacillin against planktonic cells and biofilm of methicillin-resistant Staphylococcus aureus strains |
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