NDP-MSH treatment recovers marginal lungs during ex vivo lung perfusion (EVLP)

•Targeting the Melanocortin pathway exerts multiple beneficial effects on injured lungs.•The use of marginal organs is increasing to cope with organ shortage in lung transplantation.•NDP-MSH, a synthetic melanocortin peptide, was administered during rat lung ex vivo perfusion.•NDP-MSH reduced inflam...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2021-07, Vol.141, p.170552-170552, Article 170552
Hauptverfasser:	Lonati, Caterina, Battistin, Michele, Dondossola, Daniele E., Bassani, Giulia A., Brambilla, Daniela, Merighi, Riccardo, Leonardi, Patrizia, Carlin, Andrea, Meroni, Marica, Zanella, Alberto, Catania, Anna, Gatti, Stefano
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism alpha-MSH - analogs & derivatives alpha-MSH - pharmacology Animals Cardiac death (CD) Death Ex vivo lung perfusion (EVLP) Ex vivo reconditioning Hyaluronic Acid - metabolism Inflammation Mediators - metabolism Ischemia/reperfusion (IR) Lactic Acid - metabolism Lung - drug effects Lung - physiology Lung - physiopathology Male Melanocortin receptor (MCR) Organ Culture Techniques Perfusion - adverse effects Perfusion - methods Pulmonary Edema - etiology Rats Rats, Sprague-Dawley Receptors, Melanocortin - genetics Receptors, Melanocortin - metabolism Reperfusion Injury - prevention & control α-Melanocyte-stimulating hormone [Nle4, d-Phe7]-α-MSH (NDP-MSH)
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