Materials for Improving Immune Cell Transfection

Chimeric antigen receptor T cell (CAR‐T) therapy holds great promise for preventing and treating deadly diseases such as cancer. However, it remains challenging to transfect and engineer primary immune cells for clinical cell manufacturing. Conventional tools using viral vectors and bulk electropora...

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Veröffentlicht in:	Advanced materials (Weinheim) 2021-05, Vol.33 (21), p.e2007421-n/a
Hauptverfasser:	Kumar, Arun R. K., Shou, Yufeng, Chan, Brian, L., Krishaa, Tay, Andy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens chimeric antigen receptor T‐cell therapy Electroporation high‐aspect‐ratio nanostructures Humans Immune system Immunotherapy, Adoptive - methods Lymphocytes Microfluidics Nanoparticles Nanoparticles - chemistry Nanostructures - chemistry Perturbation Receptors, Chimeric Antigen - metabolism T-Lymphocytes - immunology T-Lymphocytes - metabolism Transfection - methods transfection techniques
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