Disease Progression in Children With Perinatal Human Immunodeficiency Virus Correlates With Increased PD-1+ CD8 T Cells That Coexpress Multiple Immune Checkpoints

BACKGROUNDPD-1 marks exhausted T cells, with weak effector functions. Adults living with human immunodeficiency virus (HIV) have increased levels of PD-1+ CD8 T cells that correlate with HIV disease progression, yet little is known about the role of PD-1+ CD8 T cells in children with perinatal HIV....

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Veröffentlicht in:	The Journal of infectious diseases 2021-11, Vol.224 (10), p.1785-1795
Hauptverfasser:	Tailor, Janki, Foldi, Julia, Generoso, Matthew, McCarty, Bret, Alankar, Aparna, Kilberg, Max, Mwamzuka, Mussa, Marshed, Fatma, Ahmed, Aabid, Liu, Mengling, Borkowsky, William, Unutmaz, Derya, Khaitan, Alka
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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