Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2‐CREB‐SIRT1 axis

Isoliquiritigenin (ISO) is a flavonoid extracted from the root of licorice, which serves various biological and pharmacological functions including antiinflammatory, antioxidation, liver protection, and heart protection. However, the mechanism of its action remains elusive and the direct target prot...

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Veröffentlicht in:	Phytotherapy research 2021-07, Vol.35 (7), p.3898-3915
Hauptverfasser:	Zhang, Li, Yang, Sheng‐Ye, Qi‐Li, Feng‐Rong, Liu, Xiao‐Xiao, Zhang, Wei‐Tao, Peng, Chao, Wu, Ping, Li, Ping, Li, Pingping, Xu, Xiaojun
Format:	Artikel
Sprache:	eng
Schlagworte:	CREB Cyclic AMP response element-binding protein Fatty acids Fatty liver Flavonoids Homeostasis IQGAP2 isoliquiritigenin Kinases Lipid metabolism Lipid peroxidation Lipids Liver Liver diseases Mass spectrometry Mass spectroscopy mRNA non‐alcoholic fatty liver disease (NAFLD) Oxidation Phosphorylation Proteins Proteolysis Proteomes Signaling siRNA SIRT1 SIRT1 protein Target recognition
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