Dihydroisotanshinone I induced ferroptosis and apoptosis of lung cancer cells

Danshen (Salvia miltiorrhiza Bunge) is broadly utilized in traditional Chinese medicine for lung cancer. However, it’s exact effort and mechanism on lung cancer is fully unclear. In this study, we found that dihydroisotanshinone I (DT), a pure compound extracted from danshen, can inhibit the growth...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2021-07, Vol.139, p.111585-111585, Article 111585
Hauptverfasser:	Wu, Ching-Yuan, Yang, Yao-Hsu, Lin, Yu-Shih, Chang, Geng-He, Tsai, Ming-Shao, Hsu, Cheng-Ming, Yeh, Reming-Albert, Shu, Li-Hsin, Cheng, Yu-Ching, Liu, Hung-Te
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Apoptosis - drug effects Cell Line, Tumor Dihydroisotanshinone I Ferroptosis Ferroptosis - drug effects Glutathione - metabolism Glutathione Peroxidase - metabolism GPX4 Humans Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Malondialdehyde - metabolism Mice Mice, Nude Phenanthrenes - pharmacology Phenanthrenes - therapeutic use Reactive Oxygen Species - metabolism
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