Sex and Menopause Modify the Effect of Single Nucleotide Polymorphism Genotypes on Fibrosis in NAFLD

The development of fibrosis in nonalcoholic fatty liver disease (NAFLD) is influenced by genetics, sex, and menopausal status, but whether genetic susceptibility to fibrosis is influenced by sex and reproductive status is unclear. Our aim was to identify metabolism‐related single nucleotide polymorp...

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Veröffentlicht in:	Hepatology Communications 2021-04, Vol.5 (4), p.598-607
Hauptverfasser:	Wegermann, Kara, Garrett, Melanie E., Zheng, Jiayin, Coviello, Andrea, Moylan, Cynthia A., Abdelmalek, Manal F., Chow, Shein‐Chung, Guy, Cynthia D., Diehl, Anna Mae, Ashley‐Koch, Allison, Suzuki, Ayako
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Analysis Body mass index Cardiovascular disease Chromosomes Cross-Sectional Studies Diabetes Disease susceptibility Ethnicity Female Fibrosis Gastrointestinal surgery Gender differences Gene expression Genetic aspects Genetic Predisposition to Disease Genomes Genotype Hepatitis Hormones Humans Kinases Lipids Liver Liver cancer Liver diseases Low density lipoprotein Male Medical research Medicine, Experimental Menopause Menstruation Metabolism Middle Aged Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Original Physiological aspects Polymorphism Polymorphism, Single Nucleotide Population Postmenopausal women Principal components analysis Proof of Concept Study Proteins Risk Factors Sex Factors Single nucleotide polymorphisms Type 2 diabetes Womens health
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