Polymorphisms of interleukin 4 and interleukin 4 receptor genes and bronchial asthma risk among Egyptian children

Polymorphisms of interleukin 4 and interleukin 4 receptor genes and bronchial asthma risk among Egyptian children

Interleukin 4 (IL4) is a key cytokine that regulates the inflammatory cascade in bronchial asthma. We investigated the association between the IL4 and IL4R polymorphisms and the susceptibility for bronchial asthma among Egyptian children. IL4 VNTR and IL4R c.1902 A>G p.(Q576R) polymorphisms were...

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Veröffentlicht in:Clinical biochemistry 2021-07, Vol.93, p.66-72
Hauptverfasser: Elsaid, Afaf, Shoaib, Rasha M.S., Badr, Sara S., Wahba, Yahya, Ayyad, Seif-Eldin N.
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Bronchial asthma
Interleukin 4
Interleukin 4 receptor
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container_start_page 66
container_title Clinical biochemistry
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creator Elsaid, Afaf
Shoaib, Rasha M.S.
Badr, Sara S.
Wahba, Yahya
Ayyad, Seif-Eldin N.
description Interleukin 4 (IL4) is a key cytokine that regulates the inflammatory cascade in bronchial asthma. We investigated the association between the IL4 and IL4R polymorphisms and the susceptibility for bronchial asthma among Egyptian children. IL4 VNTR and IL4R c.1902 A>G p.(Q576R) polymorphisms were investigated among 100 children with bronchial asthma and 100 healthy controls using PCR method. Serum levels of IL4 and immunoglobulin E (IgE) were assessed by ELISA. The frequencies of (A1A2 + A2A2) genotypes and A2-allele of the IL4 VNTR variant were significantly higher among asthmatic patients than controls (p = 0.01, OR = 2.34, 95% CI = 1.24–4.44; p = 0.01, OR = 2.27, 95% CI = 1.29–3.99, respectively). The frequencies of (AG + GG) genotypes and G-allele of the IL4R (A1902G) variant were significantly higher among asthmatic patients than controls (p = 0.003, OR = 2.52, 95% CI = 1.39–4.58; p = 0.002, OR = 2.25, 95% CI = 1.35–3.76, respectively). There was a significant association between (A1A2 + A2A2) genotypes of the IL4 VNTR variant and high serum IL4 level among asthmatic patients (p 
doi_str_mv 10.1016/j.clinbiochem.2021.04.006
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We investigated the association between the IL4 and IL4R polymorphisms and the susceptibility for bronchial asthma among Egyptian children. IL4 VNTR and IL4R c.1902 A&gt;G p.(Q576R) polymorphisms were investigated among 100 children with bronchial asthma and 100 healthy controls using PCR method. Serum levels of IL4 and immunoglobulin E (IgE) were assessed by ELISA. The frequencies of (A1A2 + A2A2) genotypes and A2-allele of the IL4 VNTR variant were significantly higher among asthmatic patients than controls (p = 0.01, OR = 2.34, 95% CI = 1.24–4.44; p = 0.01, OR = 2.27, 95% CI = 1.29–3.99, respectively). The frequencies of (AG + GG) genotypes and G-allele of the IL4R (A1902G) variant were significantly higher among asthmatic patients than controls (p = 0.003, OR = 2.52, 95% CI = 1.39–4.58; p = 0.002, OR = 2.25, 95% CI = 1.35–3.76, respectively). There was a significant association between (A1A2 + A2A2) genotypes of the IL4 VNTR variant and high serum IL4 level among asthmatic patients (p &lt; 0.001). The (AG + GG) genotypes of the IL4R (A1902G) variant were significantly associated with exposure to triggers, atopic dermatitis and higher serum IgE level in asthmatic patients (p = 0.02, 0.04 and 0.01, respectively). 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We investigated the association between the IL4 and IL4R polymorphisms and the susceptibility for bronchial asthma among Egyptian children. IL4 VNTR and IL4R c.1902 A&gt;G p.(Q576R) polymorphisms were investigated among 100 children with bronchial asthma and 100 healthy controls using PCR method. Serum levels of IL4 and immunoglobulin E (IgE) were assessed by ELISA. The frequencies of (A1A2 + A2A2) genotypes and A2-allele of the IL4 VNTR variant were significantly higher among asthmatic patients than controls (p = 0.01, OR = 2.34, 95% CI = 1.24–4.44; p = 0.01, OR = 2.27, 95% CI = 1.29–3.99, respectively). The frequencies of (AG + GG) genotypes and G-allele of the IL4R (A1902G) variant were significantly higher among asthmatic patients than controls (p = 0.003, OR = 2.52, 95% CI = 1.39–4.58; p = 0.002, OR = 2.25, 95% CI = 1.35–3.76, respectively). There was a significant association between (A1A2 + A2A2) genotypes of the IL4 VNTR variant and high serum IL4 level among asthmatic patients (p &lt; 0.001). The (AG + GG) genotypes of the IL4R (A1902G) variant were significantly associated with exposure to triggers, atopic dermatitis and higher serum IgE level in asthmatic patients (p = 0.02, 0.04 and 0.01, respectively). IL4 VNTR and IL4R (A1902G) polymorphisms could be associated with higher risks of bronchial asthma among Egyptian children.</description><subject>Bronchial asthma</subject><subject>Interleukin 4</subject><subject>Interleukin 4 receptor</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqNkEtLxDAQx4Mouj6-gsSbl9Y8-kiPsvgCQQ96Dmky3c3aJjXpCvvtja6KePI0zPCbGf4_hM4oySmh1cUq1711rfV6CUPOCKM5KXJCqh00o6LmGWs430UzQkiTNZSRA3QY4yq1rBDVPjrgXFS0EfUMvT76fjP4MC5tHCL2HbZugtDD-sU6XGDlzJ9JAA3j5ANegIP4CbTBO720qscqTstB4WDjC1aDdwt8tdiMk1UOJ6A3Adwx2utUH-Hkqx6h5-urp_ltdv9wcze_vM80r-spE7xkRVuaglfKtLTVtFGU8FrVSou67FjXpRS00MyYmpuq5KJshVaGd8BVy_gROt_eHYN_XUOc5GCjhr5XDvw6SlbSomwqSkRCmy2qg48xQCfHYAcVNpIS-WFcruQv4_LDuCSFTMbT7unXm3U7gPnZ_FacgPkWgBT2zUKQUVtwGoxNKidpvP3Hm3f3oZoT</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Elsaid, Afaf</creator><creator>Shoaib, Rasha M.S.</creator><creator>Badr, Sara S.</creator><creator>Wahba, Yahya</creator><creator>Ayyad, Seif-Eldin N.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5150-7491</orcidid><orcidid>https://orcid.org/0000-0001-7479-7866</orcidid></search><sort><creationdate>20210701</creationdate><title>Polymorphisms of interleukin 4 and interleukin 4 receptor genes and bronchial asthma risk among Egyptian children</title><author>Elsaid, Afaf ; Shoaib, Rasha M.S. ; Badr, Sara S. ; Wahba, Yahya ; Ayyad, Seif-Eldin N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-83524b5d436adb1bc19a1037a7ac875f2ff33814c2dd73d65385b8cad3fe3ab23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bronchial asthma</topic><topic>Interleukin 4</topic><topic>Interleukin 4 receptor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elsaid, Afaf</creatorcontrib><creatorcontrib>Shoaib, Rasha M.S.</creatorcontrib><creatorcontrib>Badr, Sara S.</creatorcontrib><creatorcontrib>Wahba, Yahya</creatorcontrib><creatorcontrib>Ayyad, Seif-Eldin N.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elsaid, Afaf</au><au>Shoaib, Rasha M.S.</au><au>Badr, Sara S.</au><au>Wahba, Yahya</au><au>Ayyad, Seif-Eldin N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms of interleukin 4 and interleukin 4 receptor genes and bronchial asthma risk among Egyptian children</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>93</volume><spage>66</spage><epage>72</epage><pages>66-72</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>Interleukin 4 (IL4) is a key cytokine that regulates the inflammatory cascade in bronchial asthma. We investigated the association between the IL4 and IL4R polymorphisms and the susceptibility for bronchial asthma among Egyptian children. IL4 VNTR and IL4R c.1902 A&gt;G p.(Q576R) polymorphisms were investigated among 100 children with bronchial asthma and 100 healthy controls using PCR method. Serum levels of IL4 and immunoglobulin E (IgE) were assessed by ELISA. The frequencies of (A1A2 + A2A2) genotypes and A2-allele of the IL4 VNTR variant were significantly higher among asthmatic patients than controls (p = 0.01, OR = 2.34, 95% CI = 1.24–4.44; p = 0.01, OR = 2.27, 95% CI = 1.29–3.99, respectively). The frequencies of (AG + GG) genotypes and G-allele of the IL4R (A1902G) variant were significantly higher among asthmatic patients than controls (p = 0.003, OR = 2.52, 95% CI = 1.39–4.58; p = 0.002, OR = 2.25, 95% CI = 1.35–3.76, respectively). There was a significant association between (A1A2 + A2A2) genotypes of the IL4 VNTR variant and high serum IL4 level among asthmatic patients (p &lt; 0.001). The (AG + GG) genotypes of the IL4R (A1902G) variant were significantly associated with exposure to triggers, atopic dermatitis and higher serum IgE level in asthmatic patients (p = 0.02, 0.04 and 0.01, respectively). IL4 VNTR and IL4R (A1902G) polymorphisms could be associated with higher risks of bronchial asthma among Egyptian children.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33861987</pmid><doi>10.1016/j.clinbiochem.2021.04.006</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5150-7491</orcidid><orcidid>https://orcid.org/0000-0001-7479-7866</orcidid></addata></record>
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subjects Bronchial asthma
Interleukin 4
Interleukin 4 receptor
title Polymorphisms of interleukin 4 and interleukin 4 receptor genes and bronchial asthma risk among Egyptian children
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