Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms – Findings from Helsinki Birth Cohort Study
Millions of people live with depression and its burden of disease. Depression has an increased comorbidity and mortality that has remained unexplained. Studies have reported connections between advanced glycation end products (AGEs) and various disease processes, including mental health. The present...
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| Veröffentlicht in: | Journal of psychosomatic research 2021-06, Vol.145, p.110488-110488, Article 110488 |
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| creator | Eriksson, Mia D. Eriksson, Johan G. Kautiainen, Hannu Salonen, Minna K. Mikkola, Tuija M. Kajantie, Eero Wasenius, Niko von Bonsdorff, Mikaela Laine, Merja K. |
| description | Millions of people live with depression and its burden of disease. Depression has an increased comorbidity and mortality that has remained unexplained. Studies have reported connections between advanced glycation end products (AGEs) and various disease processes, including mental health. The present study evaluated associations between AGEs, depressive symptoms, and types of depressive symptoms.
From the Helsinki Birth Cohort Study, 815 participants with a mean age of 76 years were recruited for this cross-sectional study. Characteristics regarding self-reported lifestyle and medical history, as well as blood tests were obtained along with responses regarding depressive symptoms according to the Beck Depression Inventory (BDI) and Mental Health Inventory-5. Each participant had their AGE level measured non-invasively with skin autofluorescence (SAF). Statistical analyses looked at relationships between types of depressive symptoms and AGE levels by sex.
Of women, 27% scored ≥10 on the BDI and 18% of men, respectively. Men had higher crude AGE levels (mean [standard deviation], arbitrary units) (2.49 [0.51]) compared to women (2.33 [0.46]) (p |
| doi_str_mv | 10.1016/j.jpsychores.2021.110488 |
| format | Article |
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From the Helsinki Birth Cohort Study, 815 participants with a mean age of 76 years were recruited for this cross-sectional study. Characteristics regarding self-reported lifestyle and medical history, as well as blood tests were obtained along with responses regarding depressive symptoms according to the Beck Depression Inventory (BDI) and Mental Health Inventory-5. Each participant had their AGE level measured non-invasively with skin autofluorescence (SAF). Statistical analyses looked at relationships between types of depressive symptoms and AGE levels by sex.
Of women, 27% scored ≥10 on the BDI and 18% of men, respectively. Men had higher crude AGE levels (mean [standard deviation], arbitrary units) (2.49 [0.51]) compared to women (2.33 [0.46]) (p < 0.001). The highest crude AGE levels were found in those with melancholic depressive symptoms (2.61 [0.57]), followed by those with non-melancholic depressive symptoms (2.45 [0.45]) and those with no depressive symptoms (2.38 [0.49]) (p = 0.013). These findings remained significant in the fully adjusted model.
The current study shows an association between depressive symptoms and higher AGE levels. The association is likely part of a multi-factorial effect, and hence no directionality, causality, or effect can be inferred solely based on the results of this study.
•AGE association with non-melancholic vs melancholic depressive symptoms•Association between advanced glycation end products and depressive symptoms•Higher AGE levels with melancholic depressive symptoms than no depressive symptoms•Skin autofluorescence used for AGE measurement in a geriatric population</description><identifier>ISSN: 0022-3999</identifier><identifier>EISSN: 1879-1360</identifier><identifier>DOI: 10.1016/j.jpsychores.2021.110488</identifier><identifier>PMID: 33863506</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Advanced glycation end products ; Advanced glycosylation end products ; Age ; Biomarkers ; Blood tests ; Causality ; Childbirth & labor ; Cohort analysis ; Cohort studies ; Comorbidity ; Depression ; Depressive disorder ; Glycosylation ; Inflammation ; Medical history ; Mental depression ; Mental health ; Statistical analysis ; Symptoms</subject><ispartof>Journal of psychosomatic research, 2021-06, Vol.145, p.110488-110488, Article 110488</ispartof><rights>2021 The Author(s)</rights><rights>Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Jun 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-b19afd4b270b247b86701190245adaabd9a055985ccff1058f04e991c4258dc53</citedby><cites>FETCH-LOGICAL-c452t-b19afd4b270b247b86701190245adaabd9a055985ccff1058f04e991c4258dc53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022399921001331$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,30976,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33863506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eriksson, Mia D.</creatorcontrib><creatorcontrib>Eriksson, Johan G.</creatorcontrib><creatorcontrib>Kautiainen, Hannu</creatorcontrib><creatorcontrib>Salonen, Minna K.</creatorcontrib><creatorcontrib>Mikkola, Tuija M.</creatorcontrib><creatorcontrib>Kajantie, Eero</creatorcontrib><creatorcontrib>Wasenius, Niko</creatorcontrib><creatorcontrib>von Bonsdorff, Mikaela</creatorcontrib><creatorcontrib>Laine, Merja K.</creatorcontrib><title>Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms – Findings from Helsinki Birth Cohort Study</title><title>Journal of psychosomatic research</title><addtitle>J Psychosom Res</addtitle><description>Millions of people live with depression and its burden of disease. Depression has an increased comorbidity and mortality that has remained unexplained. Studies have reported connections between advanced glycation end products (AGEs) and various disease processes, including mental health. The present study evaluated associations between AGEs, depressive symptoms, and types of depressive symptoms.
From the Helsinki Birth Cohort Study, 815 participants with a mean age of 76 years were recruited for this cross-sectional study. Characteristics regarding self-reported lifestyle and medical history, as well as blood tests were obtained along with responses regarding depressive symptoms according to the Beck Depression Inventory (BDI) and Mental Health Inventory-5. Each participant had their AGE level measured non-invasively with skin autofluorescence (SAF). Statistical analyses looked at relationships between types of depressive symptoms and AGE levels by sex.
Of women, 27% scored ≥10 on the BDI and 18% of men, respectively. Men had higher crude AGE levels (mean [standard deviation], arbitrary units) (2.49 [0.51]) compared to women (2.33 [0.46]) (p < 0.001). The highest crude AGE levels were found in those with melancholic depressive symptoms (2.61 [0.57]), followed by those with non-melancholic depressive symptoms (2.45 [0.45]) and those with no depressive symptoms (2.38 [0.49]) (p = 0.013). These findings remained significant in the fully adjusted model.
The current study shows an association between depressive symptoms and higher AGE levels. The association is likely part of a multi-factorial effect, and hence no directionality, causality, or effect can be inferred solely based on the results of this study.
•AGE association with non-melancholic vs melancholic depressive symptoms•Association between advanced glycation end products and depressive symptoms•Higher AGE levels with melancholic depressive symptoms than no depressive symptoms•Skin autofluorescence used for AGE measurement in a geriatric population</description><subject>Advanced glycation end products</subject><subject>Advanced glycosylation end products</subject><subject>Age</subject><subject>Biomarkers</subject><subject>Blood tests</subject><subject>Causality</subject><subject>Childbirth & labor</subject><subject>Cohort analysis</subject><subject>Cohort studies</subject><subject>Comorbidity</subject><subject>Depression</subject><subject>Depressive disorder</subject><subject>Glycosylation</subject><subject>Inflammation</subject><subject>Medical history</subject><subject>Mental depression</subject><subject>Mental health</subject><subject>Statistical analysis</subject><subject>Symptoms</subject><issn>0022-3999</issn><issn>1879-1360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNqFkcFu1DAURS0EokPhF5AlNmwy2E6ciZftiFKkSiyAteXYTsdpEg9-zqDs-Ac-gT_rl_SNpoDEhoXlhc-9711fQihna854_a5f93tY7C4mD2vBBF9zzqqmeUJWvNmogpc1e0pWjAlRlEqpM_ICoGeM1UrI5-SsLJu6lKxekV8X7mAm6x29HRZrcogT9ZOj-xTdbDPQ0RuYE763C4W7MFEz59gN83G09aikJuEBiDaYjNz3kHeoGtB1F4dgqfN7ZCEcPIVl3Oc4Ar3_8ZNehcmF6RZol-JIr_0AYboL9DIkNNhGDJfp5zy75SV51pkB_KvH-5x8vXr_ZXtd3Hz68HF7cVPYSopctFyZzlWt2LBWVJu2qTeMc8VEJY0zpnXKMClVI63tOs5k07HKK8VtJWTjrCzPyduTL4b_NnvIegyYccAoPs6gheSVVFJWHNE3_6B9nNOE2yFVCq7qWtZINSfKpgiQfKf3KYwmLZozfSxS9_pvkfpYpD4VidLXjwPmdvTuj_B3cwhcngD8N38IPmmw4diHC8nbrF0M_5_yAAFruMo</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Eriksson, Mia D.</creator><creator>Eriksson, Johan G.</creator><creator>Kautiainen, Hannu</creator><creator>Salonen, Minna K.</creator><creator>Mikkola, Tuija M.</creator><creator>Kajantie, Eero</creator><creator>Wasenius, Niko</creator><creator>von Bonsdorff, Mikaela</creator><creator>Laine, Merja K.</creator><general>Elsevier Inc</general><general>Elsevier Science Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>202106</creationdate><title>Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms – Findings from Helsinki Birth Cohort Study</title><author>Eriksson, Mia D. ; Eriksson, Johan G. ; Kautiainen, Hannu ; Salonen, Minna K. ; Mikkola, Tuija M. ; Kajantie, Eero ; Wasenius, Niko ; von Bonsdorff, Mikaela ; Laine, Merja K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-b19afd4b270b247b86701190245adaabd9a055985ccff1058f04e991c4258dc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Advanced glycation end products</topic><topic>Advanced glycosylation end products</topic><topic>Age</topic><topic>Biomarkers</topic><topic>Blood tests</topic><topic>Causality</topic><topic>Childbirth & labor</topic><topic>Cohort analysis</topic><topic>Cohort studies</topic><topic>Comorbidity</topic><topic>Depression</topic><topic>Depressive disorder</topic><topic>Glycosylation</topic><topic>Inflammation</topic><topic>Medical history</topic><topic>Mental depression</topic><topic>Mental health</topic><topic>Statistical analysis</topic><topic>Symptoms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eriksson, Mia D.</creatorcontrib><creatorcontrib>Eriksson, Johan G.</creatorcontrib><creatorcontrib>Kautiainen, Hannu</creatorcontrib><creatorcontrib>Salonen, Minna K.</creatorcontrib><creatorcontrib>Mikkola, Tuija M.</creatorcontrib><creatorcontrib>Kajantie, Eero</creatorcontrib><creatorcontrib>Wasenius, Niko</creatorcontrib><creatorcontrib>von Bonsdorff, Mikaela</creatorcontrib><creatorcontrib>Laine, Merja K.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychosomatic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eriksson, Mia D.</au><au>Eriksson, Johan G.</au><au>Kautiainen, Hannu</au><au>Salonen, Minna K.</au><au>Mikkola, Tuija M.</au><au>Kajantie, Eero</au><au>Wasenius, Niko</au><au>von Bonsdorff, Mikaela</au><au>Laine, Merja K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms – Findings from Helsinki Birth Cohort Study</atitle><jtitle>Journal of psychosomatic research</jtitle><addtitle>J Psychosom Res</addtitle><date>2021-06</date><risdate>2021</risdate><volume>145</volume><spage>110488</spage><epage>110488</epage><pages>110488-110488</pages><artnum>110488</artnum><issn>0022-3999</issn><eissn>1879-1360</eissn><abstract>Millions of people live with depression and its burden of disease. Depression has an increased comorbidity and mortality that has remained unexplained. Studies have reported connections between advanced glycation end products (AGEs) and various disease processes, including mental health. The present study evaluated associations between AGEs, depressive symptoms, and types of depressive symptoms.
From the Helsinki Birth Cohort Study, 815 participants with a mean age of 76 years were recruited for this cross-sectional study. Characteristics regarding self-reported lifestyle and medical history, as well as blood tests were obtained along with responses regarding depressive symptoms according to the Beck Depression Inventory (BDI) and Mental Health Inventory-5. Each participant had their AGE level measured non-invasively with skin autofluorescence (SAF). Statistical analyses looked at relationships between types of depressive symptoms and AGE levels by sex.
Of women, 27% scored ≥10 on the BDI and 18% of men, respectively. Men had higher crude AGE levels (mean [standard deviation], arbitrary units) (2.49 [0.51]) compared to women (2.33 [0.46]) (p < 0.001). The highest crude AGE levels were found in those with melancholic depressive symptoms (2.61 [0.57]), followed by those with non-melancholic depressive symptoms (2.45 [0.45]) and those with no depressive symptoms (2.38 [0.49]) (p = 0.013). These findings remained significant in the fully adjusted model.
The current study shows an association between depressive symptoms and higher AGE levels. The association is likely part of a multi-factorial effect, and hence no directionality, causality, or effect can be inferred solely based on the results of this study.
•AGE association with non-melancholic vs melancholic depressive symptoms•Association between advanced glycation end products and depressive symptoms•Higher AGE levels with melancholic depressive symptoms than no depressive symptoms•Skin autofluorescence used for AGE measurement in a geriatric population</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>33863506</pmid><doi>10.1016/j.jpsychores.2021.110488</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Advanced glycation end products Advanced glycosylation end products Age Biomarkers Blood tests Causality Childbirth & labor Cohort analysis Cohort studies Comorbidity Depression Depressive disorder Glycosylation Inflammation Medical history Mental depression Mental health Statistical analysis Symptoms |
| title | Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms – Findings from Helsinki Birth Cohort Study |
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