The impact of timely cancer diagnosis on age disparities in colon cancer survival
We described the role of patient-related and clinical factors on age disparities in colon cancer survival among patients aged 50–99 using New Zealand population-based cancer registry data linked to hospitalisation data. We included 21,270 new colon cancer cases diagnosed between 1 January 2006 and 3...
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| Veröffentlicht in: | Journal of geriatric oncology 2021-09, Vol.12 (7), p.1044-1051 |
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| container_title | Journal of geriatric oncology |
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| creator | Pilleron, Sophie Maringe, Camille Charvat, Hadrien Atkinson, June Morris, Eva J A Sarfati, Diana |
| description | We described the role of patient-related and clinical factors on age disparities in colon cancer survival among patients aged 50–99 using New Zealand population-based cancer registry data linked to hospitalisation data.
We included 21,270 new colon cancer cases diagnosed between 1 January 2006 and 31 July 2017, followed up to end 2019. We modelled the effect of age at diagnosis, sex, ethnicity, deprivation, comorbidity, and emergency presentation on colon cancer survival by stage at diagnosis using flexible excess hazard regression models.
The excess mortality in older patients was minimal for localised cancers, maximal during the first six months for regional cancers, the first eighteen months for distant cancers, and over the three years for missing stages. The age pattern of the excess mortality hazard varied according to sex for distant cancers, emergency presentation for regional and distant cancers, and comorbidity for cancer with missing stages. Ethnicity and deprivation did not influence age disparities in colon cancer survival.
Factors reflecting timeliness of cancer diagnosis most affected age-related disparities in colon cancer survival, probably by impacting treatment strategy. Because of the high risk of poor outcomes related to treatment in older patients, efforts made to improve earlier diagnosis in older patients are likely to help reduce age disparities in colon cancer survival in New Zealand. |
| doi_str_mv | 10.1016/j.jgo.2021.04.003 |
| format | Article |
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We included 21,270 new colon cancer cases diagnosed between 1 January 2006 and 31 July 2017, followed up to end 2019. We modelled the effect of age at diagnosis, sex, ethnicity, deprivation, comorbidity, and emergency presentation on colon cancer survival by stage at diagnosis using flexible excess hazard regression models.
The excess mortality in older patients was minimal for localised cancers, maximal during the first six months for regional cancers, the first eighteen months for distant cancers, and over the three years for missing stages. The age pattern of the excess mortality hazard varied according to sex for distant cancers, emergency presentation for regional and distant cancers, and comorbidity for cancer with missing stages. Ethnicity and deprivation did not influence age disparities in colon cancer survival.
Factors reflecting timeliness of cancer diagnosis most affected age-related disparities in colon cancer survival, probably by impacting treatment strategy. Because of the high risk of poor outcomes related to treatment in older patients, efforts made to improve earlier diagnosis in older patients are likely to help reduce age disparities in colon cancer survival in New Zealand.</description><identifier>ISSN: 1879-4068</identifier><identifier>EISSN: 1879-4076</identifier><identifier>DOI: 10.1016/j.jgo.2021.04.003</identifier><identifier>PMID: 33863698</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Aged ; Cancer ; Colon ; Colonic Neoplasms - diagnosis ; Colonic Neoplasms - pathology ; Comorbidity ; Humans ; Neoplasm Staging ; New Zealand - epidemiology ; Observational data ; Older adults ; Population-based cancer registry ; Proportional Hazards Models ; Survival ; Time Factors</subject><ispartof>Journal of geriatric oncology, 2021-09, Vol.12 (7), p.1044-1051</ispartof><rights>2021 The Authors</rights><rights>Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-b50c058ccbb5386a7e32e9219f9f5d6c462148d4973457a86be01e6c30b0b7703</citedby><cites>FETCH-LOGICAL-c396t-b50c058ccbb5386a7e32e9219f9f5d6c462148d4973457a86be01e6c30b0b7703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jgo.2021.04.003$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33863698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pilleron, Sophie</creatorcontrib><creatorcontrib>Maringe, Camille</creatorcontrib><creatorcontrib>Charvat, Hadrien</creatorcontrib><creatorcontrib>Atkinson, June</creatorcontrib><creatorcontrib>Morris, Eva J A</creatorcontrib><creatorcontrib>Sarfati, Diana</creatorcontrib><title>The impact of timely cancer diagnosis on age disparities in colon cancer survival</title><title>Journal of geriatric oncology</title><addtitle>J Geriatr Oncol</addtitle><description>We described the role of patient-related and clinical factors on age disparities in colon cancer survival among patients aged 50–99 using New Zealand population-based cancer registry data linked to hospitalisation data.
We included 21,270 new colon cancer cases diagnosed between 1 January 2006 and 31 July 2017, followed up to end 2019. We modelled the effect of age at diagnosis, sex, ethnicity, deprivation, comorbidity, and emergency presentation on colon cancer survival by stage at diagnosis using flexible excess hazard regression models.
The excess mortality in older patients was minimal for localised cancers, maximal during the first six months for regional cancers, the first eighteen months for distant cancers, and over the three years for missing stages. The age pattern of the excess mortality hazard varied according to sex for distant cancers, emergency presentation for regional and distant cancers, and comorbidity for cancer with missing stages. Ethnicity and deprivation did not influence age disparities in colon cancer survival.
Factors reflecting timeliness of cancer diagnosis most affected age-related disparities in colon cancer survival, probably by impacting treatment strategy. Because of the high risk of poor outcomes related to treatment in older patients, efforts made to improve earlier diagnosis in older patients are likely to help reduce age disparities in colon cancer survival in New Zealand.</description><subject>Aged</subject><subject>Cancer</subject><subject>Colon</subject><subject>Colonic Neoplasms - diagnosis</subject><subject>Colonic Neoplasms - pathology</subject><subject>Comorbidity</subject><subject>Humans</subject><subject>Neoplasm Staging</subject><subject>New Zealand - epidemiology</subject><subject>Observational data</subject><subject>Older adults</subject><subject>Population-based cancer registry</subject><subject>Proportional Hazards Models</subject><subject>Survival</subject><subject>Time Factors</subject><issn>1879-4068</issn><issn>1879-4076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9rwyAUx2VsrKXrH7DL8LhLM43RRHYaZb-gMAbdWYx56QxJzDQt9L-fpV2P8_LE93lfnh-EbilJKKHioUmajUtSktKEZAkh7AJNaZHLRUZycXm-i2KC5iE0JB6WSpmLazRhrBBMyGKKPtffgG03aDNiV-PRdtDusdG9AY8rqze9CzZg12O9gfgQBu3taCFg22Pj2tg4wWHrd3an2xt0Ves2wPxUZ-jr5Xm9fFusPl7fl0-rhWFSjIuSE0N4YUxZ8riNzoGlIFMqa1nzSphMpDQrqkzmLOO5LkQJhIIwjJSkzHPCZuj-mDt497OFMKrOBgNtq3tw26BSTjMuOac0ovSIGu9C8FCrwdtO-72iRB1kqkZFmeogU5FMRVNx5u4Uvy07qM4Tf-oi8HgEIH5yZ8GrYCxEFZX1YEZVOftP_C_vv4Pe</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Pilleron, Sophie</creator><creator>Maringe, Camille</creator><creator>Charvat, Hadrien</creator><creator>Atkinson, June</creator><creator>Morris, Eva J A</creator><creator>Sarfati, Diana</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202109</creationdate><title>The impact of timely cancer diagnosis on age disparities in colon cancer survival</title><author>Pilleron, Sophie ; Maringe, Camille ; Charvat, Hadrien ; Atkinson, June ; Morris, Eva J A ; Sarfati, Diana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-b50c058ccbb5386a7e32e9219f9f5d6c462148d4973457a86be01e6c30b0b7703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Cancer</topic><topic>Colon</topic><topic>Colonic Neoplasms - diagnosis</topic><topic>Colonic Neoplasms - pathology</topic><topic>Comorbidity</topic><topic>Humans</topic><topic>Neoplasm Staging</topic><topic>New Zealand - epidemiology</topic><topic>Observational data</topic><topic>Older adults</topic><topic>Population-based cancer registry</topic><topic>Proportional Hazards Models</topic><topic>Survival</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pilleron, Sophie</creatorcontrib><creatorcontrib>Maringe, Camille</creatorcontrib><creatorcontrib>Charvat, Hadrien</creatorcontrib><creatorcontrib>Atkinson, June</creatorcontrib><creatorcontrib>Morris, Eva J A</creatorcontrib><creatorcontrib>Sarfati, Diana</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of geriatric oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pilleron, Sophie</au><au>Maringe, Camille</au><au>Charvat, Hadrien</au><au>Atkinson, June</au><au>Morris, Eva J A</au><au>Sarfati, Diana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of timely cancer diagnosis on age disparities in colon cancer survival</atitle><jtitle>Journal of geriatric oncology</jtitle><addtitle>J Geriatr Oncol</addtitle><date>2021-09</date><risdate>2021</risdate><volume>12</volume><issue>7</issue><spage>1044</spage><epage>1051</epage><pages>1044-1051</pages><issn>1879-4068</issn><eissn>1879-4076</eissn><abstract>We described the role of patient-related and clinical factors on age disparities in colon cancer survival among patients aged 50–99 using New Zealand population-based cancer registry data linked to hospitalisation data.
We included 21,270 new colon cancer cases diagnosed between 1 January 2006 and 31 July 2017, followed up to end 2019. We modelled the effect of age at diagnosis, sex, ethnicity, deprivation, comorbidity, and emergency presentation on colon cancer survival by stage at diagnosis using flexible excess hazard regression models.
The excess mortality in older patients was minimal for localised cancers, maximal during the first six months for regional cancers, the first eighteen months for distant cancers, and over the three years for missing stages. The age pattern of the excess mortality hazard varied according to sex for distant cancers, emergency presentation for regional and distant cancers, and comorbidity for cancer with missing stages. Ethnicity and deprivation did not influence age disparities in colon cancer survival.
Factors reflecting timeliness of cancer diagnosis most affected age-related disparities in colon cancer survival, probably by impacting treatment strategy. Because of the high risk of poor outcomes related to treatment in older patients, efforts made to improve earlier diagnosis in older patients are likely to help reduce age disparities in colon cancer survival in New Zealand.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>33863698</pmid><doi>10.1016/j.jgo.2021.04.003</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aged Cancer Colon Colonic Neoplasms - diagnosis Colonic Neoplasms - pathology Comorbidity Humans Neoplasm Staging New Zealand - epidemiology Observational data Older adults Population-based cancer registry Proportional Hazards Models Survival Time Factors |
| title | The impact of timely cancer diagnosis on age disparities in colon cancer survival |
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