Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93

The interleukin (IL)-17 family, consisting of six members, promotes host defense but can in some context promote the development of autoimmune disease. Here, we examined the role of IL-17D, a poorly understood member in the IL-17 family. IL-17D was expressed primarily by colonic epithelial cells. Il...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2021-04, Vol.54 (4), p.673-686.e4
Hauptverfasser:	Huang, Jinling, Lee, Hae-youn, Zhao, Xiaohong, Han, Jinyi, Su, Yang, Sun, Qinli, Shao, Jing, Ge, Jiwan, Zhao, Yuxi, Bai, Xue, He, Yi, Wang, Xinquan, Wang, Xiaohu, Dong, Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antiinfectives and antibacterials Antimicrobial peptides Autoimmune diseases Bacterial diseases Bone marrow Cancer Cell Line Colitis Colitis - immunology Colon Colon - immunology Colon cancer Colorectal cancer Cytokines Dysbacteriosis Epithelial cells Epithelial Cells - immunology Epithelium Gene expression Glycoproteins Homeostasis Immunity, Innate - immunology Inflammation Inflammatory bowel disease Interleukin 1 Interleukin 17 Interleukin 22 Interleukin-27 - immunology Interleukins - immunology Intestine Lymphocytes Lymphocytes - immunology Lymphoid cells Male Membrane Glycoproteins - immunology Mice Mice, Inbred C57BL Microorganisms Pathogens Peptides Physiology Protein composition Protein purification RAW 264.7 Cells Receptors Rodents Roles Small intestine Thymus gland Transcription factors
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