Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms

Vertebrates have evolved three paralogs, termed LUC7L, LUC7L2, and LUC7L3, of the essential yeast U1 small nuclear RNA (snRNA)-associated splicing factor Luc7p. We investigated the mechanistic and regulatory functions of these putative splicing factors, of which one (LUC7L2) is mutated or deleted in...

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Veröffentlicht in:	Cell reports (Cambridge) 2021-04, Vol.35 (2), p.108989-108989, Article 108989
Hauptverfasser:	Daniels, Noah J., Hershberger, Courtney E., Gu, Xiaorong, Schueger, Caroline, DiPasquale, William M., Brick, Jonathan, Saunthararajah, Yogen, Maciejewski, Jaroslaw P., Padgett, Richard A.
Format:	Artikel
Sprache:	eng
Schlagworte:	5′ splice site alternative splicing Base Sequence Cell Biology Exons Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Introns Leukemia, Myeloid - genetics Leukemia, Myeloid - metabolism Leukemia, Myeloid - pathology Life Sciences & Biomedicine LUC7L LUC7L2 LUC7L3 Mutation Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - metabolism Myelodysplastic Syndromes - pathology myeloid neoplasms Nuclear Proteins - genetics Nuclear Proteins - metabolism Ribonucleoprotein, U1 Small Nuclear - genetics Ribonucleoprotein, U1 Small Nuclear - metabolism RNA Splicing RNA, Small Nuclear - genetics RNA, Small Nuclear - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Science & Technology Signal Transduction Spliceosomes
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