Onychomycosis in patients with multiple sclerosis: prevalence, clinical description, mycological, and dermoscopic study in a Mexican population
Background Multiple sclerosis (MS) is a chronic demyelinating disease related to HLA‐DR8. Susceptibility to onychomycosis has been found in Mexican mestizos with HLA‐DR8. The frequency of onychomycosis in this neurological disease is unknown. Objectives To determine the frequency of onychomycosis an...
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| Veröffentlicht in: | International journal of dermatology 2021-09, Vol.60 (9), p.1102-1108 |
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| container_title | International journal of dermatology |
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| creator | Sánchez‐Cárdenas, Carlos D. Vega‐Sánchez, Diana Vargas‐Santana, Sarah B. Flores‐Rivera, José Arenas, Roberto Corona, Teresa |
| description | Background
Multiple sclerosis (MS) is a chronic demyelinating disease related to HLA‐DR8. Susceptibility to onychomycosis has been found in Mexican mestizos with HLA‐DR8. The frequency of onychomycosis in this neurological disease is unknown.
Objectives
To determine the frequency of onychomycosis and its clinical, mycological, and dermoscopic characteristics in patients with MS in comparison with the general population.
Methods
Observational, cross‐sectional, case–control study in patients with MS from October 2017 to February 2018. Age, gender, MS type, and time of progression from diagnosis to date and baseline treatment were collected after signed informed consent. A neurological exploration and clinical examination of fingernails and toenails for onychomycosis was conducted. Mycological and dermoscopic studies of the infected nails were performed on patients with clinical diagnosis of onychomycosis. A healthy control group was taken for each case (1:1), paired by age and gender.
Results
The frequency of onychomycosis in patients with MS was higher than the healthy population (32% vs. 26%, P = 0.509). A higher frequency of non‐dermatophyte fungi was found, although it was not statistically significant. The clinical manifestations and dermoscopic findings in patients with MS and onychomycosis were similar to those of the general population.
Conclusion
The frequency of onychomycosis in patients with MS is slightly higher than that of the general population. A possible association of HLA‐DR8 as a susceptibility factor for onychomycosis is proposed. The etiology of opportunistic fungi in MS patients with onychomycosis may be related to immunosuppressive treatment. |
| doi_str_mv | 10.1111/ijd.15580 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2513242621</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2513242621</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3130-6cc480ce2e0487fe23a5f2387be83b86ddcfec9ef4a504fd2ca6cc283165a1a53</originalsourceid><addsrcrecordid>eNp1kU1P3DAQhq0KVLbQQ_9AZYkLlTbgjzib7a2C8iUQFzhH3smkeOXYqZ0A-RX9yzgs9ICEL5Y1zzxjzUvIN84OeTpHZl0fcqVK9onMuCxUlhdSbJEZY5xnS6aWO-RLjOv0lILnn8mOlKVSC6Zm5N-NG-HetyP4aCI1jna6N-j6SB9Nf0_bwfams0gjWAwT85N2AR-0RQc4p2CNM6AtrTFCMF1vvJvTSWf9n6kwp9rVqRpaH8F3Bmjsh3qcJml6jU-JSTN9N1g99e6R7UbbiF9f711yd_r79vg8u7o5uzj-dZWB5JJlBUBeMkCBLC8XDQqpVSNkuVhhKVdlUdfQICyxybVieVML0KlFlJIXSnOt5C452Hi74P8OGPuqNRHQWu3QD7ESKu0qF4XgCd1_h679EFz6XaIKnqukFYn6saEgbSkGbKoumFaHseKsmlKqUkrVS0qJ_f5qHFYt1v_Jt1gScLQBHo3F8WNTdXF5slE-AwO5ntY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2561452832</pqid></control><display><type>article</type><title>Onychomycosis in patients with multiple sclerosis: prevalence, clinical description, mycological, and dermoscopic study in a Mexican population</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Sánchez‐Cárdenas, Carlos D. ; Vega‐Sánchez, Diana ; Vargas‐Santana, Sarah B. ; Flores‐Rivera, José ; Arenas, Roberto ; Corona, Teresa</creator><creatorcontrib>Sánchez‐Cárdenas, Carlos D. ; Vega‐Sánchez, Diana ; Vargas‐Santana, Sarah B. ; Flores‐Rivera, José ; Arenas, Roberto ; Corona, Teresa</creatorcontrib><description>Background
Multiple sclerosis (MS) is a chronic demyelinating disease related to HLA‐DR8. Susceptibility to onychomycosis has been found in Mexican mestizos with HLA‐DR8. The frequency of onychomycosis in this neurological disease is unknown.
Objectives
To determine the frequency of onychomycosis and its clinical, mycological, and dermoscopic characteristics in patients with MS in comparison with the general population.
Methods
Observational, cross‐sectional, case–control study in patients with MS from October 2017 to February 2018. Age, gender, MS type, and time of progression from diagnosis to date and baseline treatment were collected after signed informed consent. A neurological exploration and clinical examination of fingernails and toenails for onychomycosis was conducted. Mycological and dermoscopic studies of the infected nails were performed on patients with clinical diagnosis of onychomycosis. A healthy control group was taken for each case (1:1), paired by age and gender.
Results
The frequency of onychomycosis in patients with MS was higher than the healthy population (32% vs. 26%, P = 0.509). A higher frequency of non‐dermatophyte fungi was found, although it was not statistically significant. The clinical manifestations and dermoscopic findings in patients with MS and onychomycosis were similar to those of the general population.
Conclusion
The frequency of onychomycosis in patients with MS is slightly higher than that of the general population. A possible association of HLA‐DR8 as a susceptibility factor for onychomycosis is proposed. The etiology of opportunistic fungi in MS patients with onychomycosis may be related to immunosuppressive treatment.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/ijd.15580</identifier><identifier>PMID: 33855705</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Demyelinating diseases ; Demyelination ; Dermatophyte fungi ; Diagnosis ; Etiology ; Fingernail ; Fungi ; Gender ; Health services ; Histocompatibility antigen HLA ; Informed consent ; Multiple sclerosis ; Neurological diseases ; Onychomycosis ; Patients ; Population ; Population studies ; Statistical analysis ; Susceptibility</subject><ispartof>International journal of dermatology, 2021-09, Vol.60 (9), p.1102-1108</ispartof><rights>2021</rights><rights>2021 the International Society of Dermatology.</rights><rights>International Journal of Dermatology © 2021 International Society of Dermatology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3130-6cc480ce2e0487fe23a5f2387be83b86ddcfec9ef4a504fd2ca6cc283165a1a53</cites><orcidid>0000-0002-1297-3876</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijd.15580$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijd.15580$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33855705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sánchez‐Cárdenas, Carlos D.</creatorcontrib><creatorcontrib>Vega‐Sánchez, Diana</creatorcontrib><creatorcontrib>Vargas‐Santana, Sarah B.</creatorcontrib><creatorcontrib>Flores‐Rivera, José</creatorcontrib><creatorcontrib>Arenas, Roberto</creatorcontrib><creatorcontrib>Corona, Teresa</creatorcontrib><title>Onychomycosis in patients with multiple sclerosis: prevalence, clinical description, mycological, and dermoscopic study in a Mexican population</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background
Multiple sclerosis (MS) is a chronic demyelinating disease related to HLA‐DR8. Susceptibility to onychomycosis has been found in Mexican mestizos with HLA‐DR8. The frequency of onychomycosis in this neurological disease is unknown.
Objectives
To determine the frequency of onychomycosis and its clinical, mycological, and dermoscopic characteristics in patients with MS in comparison with the general population.
Methods
Observational, cross‐sectional, case–control study in patients with MS from October 2017 to February 2018. Age, gender, MS type, and time of progression from diagnosis to date and baseline treatment were collected after signed informed consent. A neurological exploration and clinical examination of fingernails and toenails for onychomycosis was conducted. Mycological and dermoscopic studies of the infected nails were performed on patients with clinical diagnosis of onychomycosis. A healthy control group was taken for each case (1:1), paired by age and gender.
Results
The frequency of onychomycosis in patients with MS was higher than the healthy population (32% vs. 26%, P = 0.509). A higher frequency of non‐dermatophyte fungi was found, although it was not statistically significant. The clinical manifestations and dermoscopic findings in patients with MS and onychomycosis were similar to those of the general population.
Conclusion
The frequency of onychomycosis in patients with MS is slightly higher than that of the general population. A possible association of HLA‐DR8 as a susceptibility factor for onychomycosis is proposed. The etiology of opportunistic fungi in MS patients with onychomycosis may be related to immunosuppressive treatment.</description><subject>Demyelinating diseases</subject><subject>Demyelination</subject><subject>Dermatophyte fungi</subject><subject>Diagnosis</subject><subject>Etiology</subject><subject>Fingernail</subject><subject>Fungi</subject><subject>Gender</subject><subject>Health services</subject><subject>Histocompatibility antigen HLA</subject><subject>Informed consent</subject><subject>Multiple sclerosis</subject><subject>Neurological diseases</subject><subject>Onychomycosis</subject><subject>Patients</subject><subject>Population</subject><subject>Population studies</subject><subject>Statistical analysis</subject><subject>Susceptibility</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kU1P3DAQhq0KVLbQQ_9AZYkLlTbgjzib7a2C8iUQFzhH3smkeOXYqZ0A-RX9yzgs9ICEL5Y1zzxjzUvIN84OeTpHZl0fcqVK9onMuCxUlhdSbJEZY5xnS6aWO-RLjOv0lILnn8mOlKVSC6Zm5N-NG-HetyP4aCI1jna6N-j6SB9Nf0_bwfams0gjWAwT85N2AR-0RQc4p2CNM6AtrTFCMF1vvJvTSWf9n6kwp9rVqRpaH8F3Bmjsh3qcJml6jU-JSTN9N1g99e6R7UbbiF9f711yd_r79vg8u7o5uzj-dZWB5JJlBUBeMkCBLC8XDQqpVSNkuVhhKVdlUdfQICyxybVieVML0KlFlJIXSnOt5C452Hi74P8OGPuqNRHQWu3QD7ESKu0qF4XgCd1_h679EFz6XaIKnqukFYn6saEgbSkGbKoumFaHseKsmlKqUkrVS0qJ_f5qHFYt1v_Jt1gScLQBHo3F8WNTdXF5slE-AwO5ntY</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Sánchez‐Cárdenas, Carlos D.</creator><creator>Vega‐Sánchez, Diana</creator><creator>Vargas‐Santana, Sarah B.</creator><creator>Flores‐Rivera, José</creator><creator>Arenas, Roberto</creator><creator>Corona, Teresa</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1297-3876</orcidid></search><sort><creationdate>202109</creationdate><title>Onychomycosis in patients with multiple sclerosis: prevalence, clinical description, mycological, and dermoscopic study in a Mexican population</title><author>Sánchez‐Cárdenas, Carlos D. ; Vega‐Sánchez, Diana ; Vargas‐Santana, Sarah B. ; Flores‐Rivera, José ; Arenas, Roberto ; Corona, Teresa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3130-6cc480ce2e0487fe23a5f2387be83b86ddcfec9ef4a504fd2ca6cc283165a1a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Demyelinating diseases</topic><topic>Demyelination</topic><topic>Dermatophyte fungi</topic><topic>Diagnosis</topic><topic>Etiology</topic><topic>Fingernail</topic><topic>Fungi</topic><topic>Gender</topic><topic>Health services</topic><topic>Histocompatibility antigen HLA</topic><topic>Informed consent</topic><topic>Multiple sclerosis</topic><topic>Neurological diseases</topic><topic>Onychomycosis</topic><topic>Patients</topic><topic>Population</topic><topic>Population studies</topic><topic>Statistical analysis</topic><topic>Susceptibility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sánchez‐Cárdenas, Carlos D.</creatorcontrib><creatorcontrib>Vega‐Sánchez, Diana</creatorcontrib><creatorcontrib>Vargas‐Santana, Sarah B.</creatorcontrib><creatorcontrib>Flores‐Rivera, José</creatorcontrib><creatorcontrib>Arenas, Roberto</creatorcontrib><creatorcontrib>Corona, Teresa</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sánchez‐Cárdenas, Carlos D.</au><au>Vega‐Sánchez, Diana</au><au>Vargas‐Santana, Sarah B.</au><au>Flores‐Rivera, José</au><au>Arenas, Roberto</au><au>Corona, Teresa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Onychomycosis in patients with multiple sclerosis: prevalence, clinical description, mycological, and dermoscopic study in a Mexican population</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2021-09</date><risdate>2021</risdate><volume>60</volume><issue>9</issue><spage>1102</spage><epage>1108</epage><pages>1102-1108</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><abstract>Background
Multiple sclerosis (MS) is a chronic demyelinating disease related to HLA‐DR8. Susceptibility to onychomycosis has been found in Mexican mestizos with HLA‐DR8. The frequency of onychomycosis in this neurological disease is unknown.
Objectives
To determine the frequency of onychomycosis and its clinical, mycological, and dermoscopic characteristics in patients with MS in comparison with the general population.
Methods
Observational, cross‐sectional, case–control study in patients with MS from October 2017 to February 2018. Age, gender, MS type, and time of progression from diagnosis to date and baseline treatment were collected after signed informed consent. A neurological exploration and clinical examination of fingernails and toenails for onychomycosis was conducted. Mycological and dermoscopic studies of the infected nails were performed on patients with clinical diagnosis of onychomycosis. A healthy control group was taken for each case (1:1), paired by age and gender.
Results
The frequency of onychomycosis in patients with MS was higher than the healthy population (32% vs. 26%, P = 0.509). A higher frequency of non‐dermatophyte fungi was found, although it was not statistically significant. The clinical manifestations and dermoscopic findings in patients with MS and onychomycosis were similar to those of the general population.
Conclusion
The frequency of onychomycosis in patients with MS is slightly higher than that of the general population. A possible association of HLA‐DR8 as a susceptibility factor for onychomycosis is proposed. The etiology of opportunistic fungi in MS patients with onychomycosis may be related to immunosuppressive treatment.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>33855705</pmid><doi>10.1111/ijd.15580</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1297-3876</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Demyelinating diseases Demyelination Dermatophyte fungi Diagnosis Etiology Fingernail Fungi Gender Health services Histocompatibility antigen HLA Informed consent Multiple sclerosis Neurological diseases Onychomycosis Patients Population Population studies Statistical analysis Susceptibility |
| title | Onychomycosis in patients with multiple sclerosis: prevalence, clinical description, mycological, and dermoscopic study in a Mexican population |
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