Effect of surfactant on the in vitro dissolution and the oral bioavailability of a weakly basic drug from an amorphous solid dispersion

This study aimed to investigate the effect of a surfactant on the liquid-liquid phase separation, dissolution, diffusion, and the oral bioavailability of a weakly basic drug (l-tetrahydropalmatine; l-THP) from an amorphous solid dispersion (ASD). The carrier used in the ASD was optimized by the appl...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2021-07, Vol.162, p.105836-105836, Article 105836
Hauptverfasser:	Tung, Nguyen-Thach, Tran, Cao-Son, Nguyen, Tran-Linh, Pham, Thi-Minh-Hue, Chi, Sang-Cheol, Nguyen, Hoang-Anh, Bui, Quang-Dong, Bui, Duc-Nhat, Tran, Thi-Quyen
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioavailability Diffusion Dissolution l-tetrahydropalmatine ∙Amorphous solid dispersion Liquid-liquid phase separation Surfactant
Online-Zugang:	Volltext
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