Renal Biopsy in Children—Effect on Treatment Decisions: A Single-Center Experience
Renal biopsy is an important diagnostic tool, though invasive and carries risks involved with sedation. The authors wanted to compare suspect histopathological diagnosis with final diagnosis and find out impact of biopsy findings on treatment. They retrospectively analyzed 108 patients. Details of p...
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| Veröffentlicht in: | Indian journal of pediatrics 2021-10, Vol.88 (10), p.1036-1039 |
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| container_title | Indian journal of pediatrics |
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| creator | Pilania, Rakesh Kumar Venkatesh, G. V. Nada, Ritambhra Vignesh, Pandiarajan Jindal, Ankur Kumar Suri, Deepti Tiewsoh, Karalanglin |
| description | Renal biopsy is an important diagnostic tool, though invasive and carries risks involved with sedation. The authors wanted to compare suspect histopathological diagnosis with final diagnosis and find out impact of biopsy findings on treatment. They retrospectively analyzed 108 patients. Details of patients, diagnosis, treatment and complications due to kidney biopsy were documented. Statistical analysis was done using SPSS version 20.0 (IBM, NY). Indications of 108 children (69 boys, 39 girls) undergoing renal biopsy were steroid-resistant nephrotic syndrome (35.1%), steroid-dependent nephrotic syndrome requiring calcineurin inhibitors (CNI) (12%), nephrotic range proteinuria with atypical features (16.7%), lupus nephritis (13%), and acute kidney injury (AKI) stage 3 (17.6%). Suspect and histopathological diagnoses were similar in 53% cases with agreement factor of 0.462. Treatment changed in 28.7%. Renal biopsy made substantial impact in patients with nephrotic range proteinuria with atypical features (55.6%) and AKI stage 3 (52.6%). One (0.9%) had developed gross hematuria, which resolved spontaneously. |
| doi_str_mv | 10.1007/s12098-021-03721-9 |
| format | Article |
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Indications of 108 children (69 boys, 39 girls) undergoing renal biopsy were steroid-resistant nephrotic syndrome (35.1%), steroid-dependent nephrotic syndrome requiring calcineurin inhibitors (CNI) (12%), nephrotic range proteinuria with atypical features (16.7%), lupus nephritis (13%), and acute kidney injury (AKI) stage 3 (17.6%). Suspect and histopathological diagnoses were similar in 53% cases with agreement factor of 0.462. Treatment changed in 28.7%. Renal biopsy made substantial impact in patients with nephrotic range proteinuria with atypical features (55.6%) and AKI stage 3 (52.6%). One (0.9%) had developed gross hematuria, which resolved spontaneously.</description><identifier>ISSN: 0019-5456</identifier><identifier>EISSN: 0973-7693</identifier><identifier>DOI: 10.1007/s12098-021-03721-9</identifier><identifier>PMID: 33847911</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Clinical Brief ; Gynecology ; Medicine ; Medicine & Public Health ; Pediatrics</subject><ispartof>Indian journal of pediatrics, 2021-10, Vol.88 (10), p.1036-1039</ispartof><rights>Dr. K C Chaudhuri Foundation 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-d4e7a55b4a4a4fe526b00bc0a2209218c5ade43104015dcc522f409355472a3e3</citedby><cites>FETCH-LOGICAL-c347t-d4e7a55b4a4a4fe526b00bc0a2209218c5ade43104015dcc522f409355472a3e3</cites><orcidid>0000-0002-0918-3056</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12098-021-03721-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12098-021-03721-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33847911$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pilania, Rakesh Kumar</creatorcontrib><creatorcontrib>Venkatesh, G. 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Indications of 108 children (69 boys, 39 girls) undergoing renal biopsy were steroid-resistant nephrotic syndrome (35.1%), steroid-dependent nephrotic syndrome requiring calcineurin inhibitors (CNI) (12%), nephrotic range proteinuria with atypical features (16.7%), lupus nephritis (13%), and acute kidney injury (AKI) stage 3 (17.6%). Suspect and histopathological diagnoses were similar in 53% cases with agreement factor of 0.462. Treatment changed in 28.7%. Renal biopsy made substantial impact in patients with nephrotic range proteinuria with atypical features (55.6%) and AKI stage 3 (52.6%). 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| subjects | Clinical Brief Gynecology Medicine Medicine & Public Health Pediatrics |
| title | Renal Biopsy in Children—Effect on Treatment Decisions: A Single-Center Experience |
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