Discovery of novel celastrol-triazole derivatives with Hsp90-Cdc37 disruption to induce tumor cell apoptosis

[Display omitted] •Compound 6 showed a higher ability to disrupt heat shock protein 90–cell division cycle 37 (Hsp90-Cdc37) interaction.•There was a enhanced covalent binding between compound 6 and thiols (cysteine).•Compound 6 arrested MDA-MB-231 cells in the G0/G1 phase, and induced apoptosis sign...

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Veröffentlicht in:	Bioorganic chemistry 2021-06, Vol.111, p.104867-104867, Article 104867
Hauptverfasser:	Li, Na, Chen, Cheng, zhu, Huiting, Shi, Zhixian, Sun, Jianbo, Chen, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiproliferative activity Celastrol derivatives Hsp90-Cdc37 interaction
Online-Zugang:	Volltext
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