Central nervous system involvement in adult-onset relapsing hemophagocytic lymphohistiocytosis responsive to maintenance treatment with anakinra
A 43 year-old male presented with a relapsing and progressive systemic inflammatory disorder with central nervous system (CNS) involvement. After a two years follow up, he was diagnosed with hemophagocytic lymphohistiocytosis (HLH), based on clinical, laboratory and radiological findings. Treatment...
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| Veröffentlicht in: | Journal of neuroimmunology 2021-06, Vol.355, p.577552-577552, Article 577552 |
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| container_title | Journal of neuroimmunology |
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| creator | Hiraldo, Juan Diego Guerra Domínguez-Mayoral, Ana García-Gómez, Francisco Javier Fouz-Rosón, Natalia Rivas-Infante, Eloy Cano, Marco Antonio Montes Fernández, Alicia Rodríguez Morillo, Salvador García Fernández, Nayua Alkadi de León, Jose Antonio Pérez Mascarell, Guillermo Navarro Lebrón, Carmen Vargas |
| description | A 43 year-old male presented with a relapsing and progressive systemic inflammatory disorder with central nervous system (CNS) involvement. After a two years follow up, he was diagnosed with hemophagocytic lymphohistiocytosis (HLH), based on clinical, laboratory and radiological findings. Treatment was started with anakinra, a recombinant humanised interleukin-1 (IL-1) receptor antagonist. Clinical response was good. Laboratory and radiological findings showed no disease activity throughout a five years follow-up period. Several immunosuppressive agents have been used in HLH without any good outcomes. This is the first case report of HLH with CNS involvement responsive to chronic treatment with anakinra.
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| doi_str_mv | 10.1016/j.jneuroim.2021.577552 |
| format | Article |
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| title | Central nervous system involvement in adult-onset relapsing hemophagocytic lymphohistiocytosis responsive to maintenance treatment with anakinra |
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