N-terminal region of RecQ4 inhibits non-homologous end joining and chromatin association of the Ku heterodimer in Xenopus egg extracts

•RecQ4 may be important in the DNA double-strand break repair pathway choice.•RecQ4 N-terminal inhibited the Xenopus linearized DNA end-joining reaction.•RecQ4 N-terminal region repressed Ku70 DSB-induced chromatin binding. RecQ4, a member of the RecQ helicase family, is required for the maintenance...

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Veröffentlicht in:	Gene 2021-06, Vol.787, p.145647-145647, Article 145647
Hauptverfasser:	Tsuyama, Takashi, Fujita, Kumiko, Sasaki, Ryosuke, Hamanaka, Shiori, Sotoyama, Yuki, Ogawa, Akira, Kusuzaki, Kana, Azuma, Yutaro, Tada, Shusuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatin DNA - metabolism DNA double-strand breaks DNA End-Joining Repair DNA repair DNA-dependent protein kinase Ku Autoantigen - antagonists & inhibitors Ku Autoantigen - metabolism Protein Binding RecQ helicase RecQ Helicases - genetics RecQ Helicases - metabolism Rothmund-Thomson syndrome Xenopus laevis Xenopus Proteins - physiology
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