Cardiac afferent signaling partially underlies premature ventricular contraction–induced cardiomyopathy

The mechanisms underlying premature ventricular contraction (PVC)–induced cardiomyopathy (PIC) remain unknown. Transient receptor potential vanilloid-1 (TRPV1) afferent fibers are implicated in the reflex processing of cardiac stress. The purpose of this study was to determine whether cardiac TRPV1...

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Veröffentlicht in:	Heart rhythm 2021-09, Vol.18 (9), p.1586-1595
Hauptverfasser:	Hori, Yuichi, Temma, Taro, Wooten, Christian, Sobowale, Christopher, Chan, Christopher, Swid, Mohammed, Ajijola, Olujimi A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Afferent Pathways - physiopathology Animal model Animals Cardiac afferent Cardiomyopathies - etiology Cardiomyopathies - pathology Cardiomyopathies - physiopathology Diterpenes - pharmacology Echocardiography - methods Fibrosis Heart - innervation Models, Animal Neurotoxins - pharmacology Premature ventricular contraction Premature ventricular contraction cardiomyopathy Signal Transduction Stroke Volume Swine Transient receptor potential vanilloid-1 afferents TRPV Cation Channels - agonists Ventricular Function, Left Ventricular Premature Complexes - complications Ventricular Premature Complexes - physiopathology
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