Clinical Significance of Serum Squamous Cell Carcinoma Antigen for Patients with Recurrent Esophageal Squamous Cell Carcinoma
Background Squamous cell carcinoma antigen (SCC-Ag) is a widely used tumor marker of SCC. However, the clinical significance of serum SCC-Ag levels in recurrent esophageal SCC (ESCC) remains unclear. This study aimed to investigate the clinical relevance of serum SCC-Ag levels in patients with recur...
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| Veröffentlicht in: | Annals of surgical oncology 2021-11, Vol.28 (12), p.7990-7996 |
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| container_title | Annals of surgical oncology |
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| creator | Kanie, Yasukazu Okamura, Akihiko Maruyama, Suguru Sakamoto, Kei Fujiwara, Daisuke Kanamori, Jun Imamura, Yu Watanabe, Masayuki |
| description | Background
Squamous cell carcinoma antigen (SCC-Ag) is a widely used tumor marker of SCC. However, the clinical significance of serum SCC-Ag levels in recurrent esophageal SCC (ESCC) remains unclear. This study aimed to investigate the clinical relevance of serum SCC-Ag levels in patients with recurrent ESCC after surgery.
Methods
This study retrospectively analyzed 208 patients who experienced recurrence after curative resection for ESCC. Serum SCC-Ag levels at the time of recurrence were collected from the patients’ records. The patients were classified into tertiles based on the serum SCC-Ag values (low, middle, and high), and the clinical characteristics and outcomes were compared among the groups.
Results
Significant differences in sex (
p
= 0.001), pathologic T (
p
= 0.034), and N stages of primary cancer (
p
= 0.015) were observed among the groups. Although the recurrence patterns did not differ significantly, a high SCC-Ag was significantly associated with multiple recurrences (
p
= 0.019). The high-SCC-Ag group patients demonstrated a shorter time to recurrence than the other groups (
p
= 0.044). The SCC-Ag levels were significantly associated with overall survival after recurrence (
p
= 0.036). Multivariate analysis showed that serum SCC-Ag value at recurrence was an independent poor prognosticator (
p
= 0.031).
Conclusion
Elevated serum SCC-Ag levels at recurrence were significantly associated with a reduced time to recurrence, multiple recurrences, and a poor prognosis after recurrence. An alternative to the current standard treatment is required to improve the outcome for patients with high serum SCC-Ag levels at recurrence. |
| doi_str_mv | 10.1245/s10434-021-09945-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2511900258</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2511900258</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-ee21d25d35db7ebf426da8d251dd10c4c894de24889d4c05cd872c4edd7652593</originalsourceid><addsrcrecordid>eNp9kU1r3DAQhkVoab76B3oogl56caNPWzoGkyaBhYRuchZaabxRsOWNZBN6yH-vkt00UEpOGo2eeTTwIvSFkh-UCXmSKRFcVITRimgtZCX30AGVpSVqRT-UmtSq0qyW--gw53tCaMOJ_IT2OVdc66Y5QE9tH2JwtsfLsI6hK2V0gMcOLyHNA14-zHYY54xb6Hvc2uRCHAeLT-MU1hBxNyZ8bacAccr4MUx3-Be4OaVyx2d53NzZNTzL_685Rh8722f4vDuP0O3Ps5v2olpcnV-2p4vK8UZOFQCjnknPpV81sOoEq71VpUO9p8QJp7TwwIRS2gtHpPOqYU6A900tmdT8CH3fejdpfJghT2YI2ZVVbISylSkmqglhUhX02z_o_TinWLYrlGJMcaF4odiWcmnMOUFnNikMNv02lJjncMw2HFPCMS_hGFmGvu7U82oA_3fkNY0C8C2Qy1NcQ3r7-x3tH6fxmzU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2582283483</pqid></control><display><type>article</type><title>Clinical Significance of Serum Squamous Cell Carcinoma Antigen for Patients with Recurrent Esophageal Squamous Cell Carcinoma</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Kanie, Yasukazu ; Okamura, Akihiko ; Maruyama, Suguru ; Sakamoto, Kei ; Fujiwara, Daisuke ; Kanamori, Jun ; Imamura, Yu ; Watanabe, Masayuki</creator><creatorcontrib>Kanie, Yasukazu ; Okamura, Akihiko ; Maruyama, Suguru ; Sakamoto, Kei ; Fujiwara, Daisuke ; Kanamori, Jun ; Imamura, Yu ; Watanabe, Masayuki</creatorcontrib><description>Background
Squamous cell carcinoma antigen (SCC-Ag) is a widely used tumor marker of SCC. However, the clinical significance of serum SCC-Ag levels in recurrent esophageal SCC (ESCC) remains unclear. This study aimed to investigate the clinical relevance of serum SCC-Ag levels in patients with recurrent ESCC after surgery.
Methods
This study retrospectively analyzed 208 patients who experienced recurrence after curative resection for ESCC. Serum SCC-Ag levels at the time of recurrence were collected from the patients’ records. The patients were classified into tertiles based on the serum SCC-Ag values (low, middle, and high), and the clinical characteristics and outcomes were compared among the groups.
Results
Significant differences in sex (
p
= 0.001), pathologic T (
p
= 0.034), and N stages of primary cancer (
p
= 0.015) were observed among the groups. Although the recurrence patterns did not differ significantly, a high SCC-Ag was significantly associated with multiple recurrences (
p
= 0.019). The high-SCC-Ag group patients demonstrated a shorter time to recurrence than the other groups (
p
= 0.044). The SCC-Ag levels were significantly associated with overall survival after recurrence (
p
= 0.036). Multivariate analysis showed that serum SCC-Ag value at recurrence was an independent poor prognosticator (
p
= 0.031).
Conclusion
Elevated serum SCC-Ag levels at recurrence were significantly associated with a reduced time to recurrence, multiple recurrences, and a poor prognosis after recurrence. An alternative to the current standard treatment is required to improve the outcome for patients with high serum SCC-Ag levels at recurrence.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-021-09945-5</identifier><identifier>PMID: 33839977</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Antigens ; Antigens, Neoplasm - blood ; Biomarkers, Tumor - blood ; Clinical significance ; Esophageal cancer ; Esophageal Neoplasms - surgery ; Esophageal Squamous Cell Carcinoma - surgery ; Esophagus ; Humans ; Medical prognosis ; Medicine ; Medicine & Public Health ; Multivariate analysis ; Neoplasm Recurrence, Local ; Oncology ; Patients ; Prognosis ; Retrospective Studies ; Serpins - blood ; Squamous cell carcinoma ; Surgery ; Surgical Oncology ; Translational Research ; Tumor markers</subject><ispartof>Annals of surgical oncology, 2021-11, Vol.28 (12), p.7990-7996</ispartof><rights>Society of Surgical Oncology 2021</rights><rights>2021. Society of Surgical Oncology.</rights><rights>Society of Surgical Oncology 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-ee21d25d35db7ebf426da8d251dd10c4c894de24889d4c05cd872c4edd7652593</citedby><cites>FETCH-LOGICAL-c375t-ee21d25d35db7ebf426da8d251dd10c4c894de24889d4c05cd872c4edd7652593</cites><orcidid>0000-0002-3217-8888</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-021-09945-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-021-09945-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33839977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kanie, Yasukazu</creatorcontrib><creatorcontrib>Okamura, Akihiko</creatorcontrib><creatorcontrib>Maruyama, Suguru</creatorcontrib><creatorcontrib>Sakamoto, Kei</creatorcontrib><creatorcontrib>Fujiwara, Daisuke</creatorcontrib><creatorcontrib>Kanamori, Jun</creatorcontrib><creatorcontrib>Imamura, Yu</creatorcontrib><creatorcontrib>Watanabe, Masayuki</creatorcontrib><title>Clinical Significance of Serum Squamous Cell Carcinoma Antigen for Patients with Recurrent Esophageal Squamous Cell Carcinoma</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Squamous cell carcinoma antigen (SCC-Ag) is a widely used tumor marker of SCC. However, the clinical significance of serum SCC-Ag levels in recurrent esophageal SCC (ESCC) remains unclear. This study aimed to investigate the clinical relevance of serum SCC-Ag levels in patients with recurrent ESCC after surgery.
Methods
This study retrospectively analyzed 208 patients who experienced recurrence after curative resection for ESCC. Serum SCC-Ag levels at the time of recurrence were collected from the patients’ records. The patients were classified into tertiles based on the serum SCC-Ag values (low, middle, and high), and the clinical characteristics and outcomes were compared among the groups.
Results
Significant differences in sex (
p
= 0.001), pathologic T (
p
= 0.034), and N stages of primary cancer (
p
= 0.015) were observed among the groups. Although the recurrence patterns did not differ significantly, a high SCC-Ag was significantly associated with multiple recurrences (
p
= 0.019). The high-SCC-Ag group patients demonstrated a shorter time to recurrence than the other groups (
p
= 0.044). The SCC-Ag levels were significantly associated with overall survival after recurrence (
p
= 0.036). Multivariate analysis showed that serum SCC-Ag value at recurrence was an independent poor prognosticator (
p
= 0.031).
Conclusion
Elevated serum SCC-Ag levels at recurrence were significantly associated with a reduced time to recurrence, multiple recurrences, and a poor prognosis after recurrence. An alternative to the current standard treatment is required to improve the outcome for patients with high serum SCC-Ag levels at recurrence.</description><subject>Antigens</subject><subject>Antigens, Neoplasm - blood</subject><subject>Biomarkers, Tumor - blood</subject><subject>Clinical significance</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophageal Squamous Cell Carcinoma - surgery</subject><subject>Esophagus</subject><subject>Humans</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multivariate analysis</subject><subject>Neoplasm Recurrence, Local</subject><subject>Oncology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Serpins - blood</subject><subject>Squamous cell carcinoma</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Translational Research</subject><subject>Tumor markers</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1r3DAQhkVoab76B3oogl56caNPWzoGkyaBhYRuchZaabxRsOWNZBN6yH-vkt00UEpOGo2eeTTwIvSFkh-UCXmSKRFcVITRimgtZCX30AGVpSVqRT-UmtSq0qyW--gw53tCaMOJ_IT2OVdc66Y5QE9tH2JwtsfLsI6hK2V0gMcOLyHNA14-zHYY54xb6Hvc2uRCHAeLT-MU1hBxNyZ8bacAccr4MUx3-Be4OaVyx2d53NzZNTzL_685Rh8722f4vDuP0O3Ps5v2olpcnV-2p4vK8UZOFQCjnknPpV81sOoEq71VpUO9p8QJp7TwwIRS2gtHpPOqYU6A900tmdT8CH3fejdpfJghT2YI2ZVVbISylSkmqglhUhX02z_o_TinWLYrlGJMcaF4odiWcmnMOUFnNikMNv02lJjncMw2HFPCMS_hGFmGvu7U82oA_3fkNY0C8C2Qy1NcQ3r7-x3tH6fxmzU</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Kanie, Yasukazu</creator><creator>Okamura, Akihiko</creator><creator>Maruyama, Suguru</creator><creator>Sakamoto, Kei</creator><creator>Fujiwara, Daisuke</creator><creator>Kanamori, Jun</creator><creator>Imamura, Yu</creator><creator>Watanabe, Masayuki</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3217-8888</orcidid></search><sort><creationdate>20211101</creationdate><title>Clinical Significance of Serum Squamous Cell Carcinoma Antigen for Patients with Recurrent Esophageal Squamous Cell Carcinoma</title><author>Kanie, Yasukazu ; Okamura, Akihiko ; Maruyama, Suguru ; Sakamoto, Kei ; Fujiwara, Daisuke ; Kanamori, Jun ; Imamura, Yu ; Watanabe, Masayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-ee21d25d35db7ebf426da8d251dd10c4c894de24889d4c05cd872c4edd7652593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antigens</topic><topic>Antigens, Neoplasm - blood</topic><topic>Biomarkers, Tumor - blood</topic><topic>Clinical significance</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophageal Squamous Cell Carcinoma - surgery</topic><topic>Esophagus</topic><topic>Humans</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multivariate analysis</topic><topic>Neoplasm Recurrence, Local</topic><topic>Oncology</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Serpins - blood</topic><topic>Squamous cell carcinoma</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Translational Research</topic><topic>Tumor markers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kanie, Yasukazu</creatorcontrib><creatorcontrib>Okamura, Akihiko</creatorcontrib><creatorcontrib>Maruyama, Suguru</creatorcontrib><creatorcontrib>Sakamoto, Kei</creatorcontrib><creatorcontrib>Fujiwara, Daisuke</creatorcontrib><creatorcontrib>Kanamori, Jun</creatorcontrib><creatorcontrib>Imamura, Yu</creatorcontrib><creatorcontrib>Watanabe, Masayuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kanie, Yasukazu</au><au>Okamura, Akihiko</au><au>Maruyama, Suguru</au><au>Sakamoto, Kei</au><au>Fujiwara, Daisuke</au><au>Kanamori, Jun</au><au>Imamura, Yu</au><au>Watanabe, Masayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Significance of Serum Squamous Cell Carcinoma Antigen for Patients with Recurrent Esophageal Squamous Cell Carcinoma</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>28</volume><issue>12</issue><spage>7990</spage><epage>7996</epage><pages>7990-7996</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Squamous cell carcinoma antigen (SCC-Ag) is a widely used tumor marker of SCC. However, the clinical significance of serum SCC-Ag levels in recurrent esophageal SCC (ESCC) remains unclear. This study aimed to investigate the clinical relevance of serum SCC-Ag levels in patients with recurrent ESCC after surgery.
Methods
This study retrospectively analyzed 208 patients who experienced recurrence after curative resection for ESCC. Serum SCC-Ag levels at the time of recurrence were collected from the patients’ records. The patients were classified into tertiles based on the serum SCC-Ag values (low, middle, and high), and the clinical characteristics and outcomes were compared among the groups.
Results
Significant differences in sex (
p
= 0.001), pathologic T (
p
= 0.034), and N stages of primary cancer (
p
= 0.015) were observed among the groups. Although the recurrence patterns did not differ significantly, a high SCC-Ag was significantly associated with multiple recurrences (
p
= 0.019). The high-SCC-Ag group patients demonstrated a shorter time to recurrence than the other groups (
p
= 0.044). The SCC-Ag levels were significantly associated with overall survival after recurrence (
p
= 0.036). Multivariate analysis showed that serum SCC-Ag value at recurrence was an independent poor prognosticator (
p
= 0.031).
Conclusion
Elevated serum SCC-Ag levels at recurrence were significantly associated with a reduced time to recurrence, multiple recurrences, and a poor prognosis after recurrence. An alternative to the current standard treatment is required to improve the outcome for patients with high serum SCC-Ag levels at recurrence.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33839977</pmid><doi>10.1245/s10434-021-09945-5</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3217-8888</orcidid></addata></record> |
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| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2021-11, Vol.28 (12), p.7990-7996 |
| issn | 1068-9265 1534-4681 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Antigens Antigens, Neoplasm - blood Biomarkers, Tumor - blood Clinical significance Esophageal cancer Esophageal Neoplasms - surgery Esophageal Squamous Cell Carcinoma - surgery Esophagus Humans Medical prognosis Medicine Medicine & Public Health Multivariate analysis Neoplasm Recurrence, Local Oncology Patients Prognosis Retrospective Studies Serpins - blood Squamous cell carcinoma Surgery Surgical Oncology Translational Research Tumor markers |
| title | Clinical Significance of Serum Squamous Cell Carcinoma Antigen for Patients with Recurrent Esophageal Squamous Cell Carcinoma |
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