Direct Effect of the Synthetic Analogue of Glucagon-Like Peptide Type 1, Liraglutide, on Mature Adipocytes Is Realized through Adenylate-Cyclase-Dependent Enhancing of Insulin Sensitivity
Incretin hormones analogues, including glucagon-like peptide type 1 (GLP-1), exhibit complex glucose-lowering, anorexigenic, and cardioprotective properties. Mechanisms of action of GLP-1 and its analogues are well known for pancreatic β-cells, hepatocytes, and other tissues. Nevertheless, local eff...
Gespeichert in:
| Veröffentlicht in: | Biochemistry (Moscow) 2021-03, Vol.86 (3), p.350-360 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 360 |
|---|---|
| container_issue | 3 |
| container_start_page | 350 |
| container_title | Biochemistry (Moscow) |
| container_volume | 86 |
| creator | Mamontova, Elizaveta D. Michurina, Svetlana S. Stafeev, Iurii S. Sorkina, Ekaterina L. Sklyanik, Igor A. Koksharova, Ekaterina O. Menshikov, Mikhail Y. Shestakova, Marina V. Parfyonova, Yelena V. |
| description | Incretin hormones analogues, including glucagon-like peptide type 1 (GLP-1), exhibit complex glucose-lowering, anorexigenic, and cardioprotective properties. Mechanisms of action of GLP-1 and its analogues are well known for pancreatic β-cells, hepatocytes, and other tissues. Nevertheless, local effects of GLP-1 and its analogues in adipose tissue remain unclear. In the present work effects of the GLP-1 synthetic analogue, liraglutide, on adipogenesis and insulin sensitivity of the 3T3-L1 adipocytes were examined. Enhancement of insulin sensitivity of mature adipocytes by the GLP-1 synthetic analogue liraglutide mediated by adenylate cyclase was demonstrated. The obtained results imply existence of the positive direct insulin-sensitizing effect of liraglutide on mature adipocytes. |
| doi_str_mv | 10.1134/S000629792103010X |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2511898919</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A656116799</galeid><sourcerecordid>A656116799</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-f50df59ff8862d0eec29b8f5a15745122b7aabbed2424c60fa190bc14afcc6453</originalsourceid><addsrcrecordid>eNp1Uktv1DAQjhCILoUfwAVZ4sKhKX4k3uS42pay0iIQWyRukeOMsy5eO7UdpPDX-HM42kLFSz6M_L1mbE2WPSf4nBBWvN5hjDmtlzUlmGGCPz_IFoTjKme4wA-zxUznM3-SPQnhJl0prtnj7ISxilWcFYvs-4X2ICO6VGouTqG4B7SbbCpRS7Sywrh-hJm5MqMUvbP5Vn8B9AGGqDtA19MAiJyhrfaiN-OMnSFn0TsRRw9o1enBySlCQJuAPoIw-ht0qYt3Y79PNNjJiAj5epJGBMgvYACb0DST3Qsrte3n5hsbRqMt2oENOuqvOk5Ps0dKmADP7upp9unN5fX6bb59f7VZr7a5LFgdc1XiTpW1UlXFaYcBJK3bSpWClMuiJJS2SyHaFjpa0EJyrASpcStJIZSUvCjZafbqmDt4dztCiM1BBwnGCAtuDA0tCanqqiZ1kr78Q3rjRp_-cFZhwkq-5MW9qhcGGm2Vi17IObRZ8ZITwpf1nHX-D1U6HRy0dBaUTvhvBnI0SO9C8KCaweuD8FNDcDMvTPPXwiTPi7uBx_YA3S_Hzw1JAnoUhETZHvz9i_6f-gM3kcsa</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2501356764</pqid></control><display><type>article</type><title>Direct Effect of the Synthetic Analogue of Glucagon-Like Peptide Type 1, Liraglutide, on Mature Adipocytes Is Realized through Adenylate-Cyclase-Dependent Enhancing of Insulin Sensitivity</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Mamontova, Elizaveta D. ; Michurina, Svetlana S. ; Stafeev, Iurii S. ; Sorkina, Ekaterina L. ; Sklyanik, Igor A. ; Koksharova, Ekaterina O. ; Menshikov, Mikhail Y. ; Shestakova, Marina V. ; Parfyonova, Yelena V.</creator><creatorcontrib>Mamontova, Elizaveta D. ; Michurina, Svetlana S. ; Stafeev, Iurii S. ; Sorkina, Ekaterina L. ; Sklyanik, Igor A. ; Koksharova, Ekaterina O. ; Menshikov, Mikhail Y. ; Shestakova, Marina V. ; Parfyonova, Yelena V.</creatorcontrib><description>Incretin hormones analogues, including glucagon-like peptide type 1 (GLP-1), exhibit complex glucose-lowering, anorexigenic, and cardioprotective properties. Mechanisms of action of GLP-1 and its analogues are well known for pancreatic β-cells, hepatocytes, and other tissues. Nevertheless, local effects of GLP-1 and its analogues in adipose tissue remain unclear. In the present work effects of the GLP-1 synthetic analogue, liraglutide, on adipogenesis and insulin sensitivity of the 3T3-L1 adipocytes were examined. Enhancement of insulin sensitivity of mature adipocytes by the GLP-1 synthetic analogue liraglutide mediated by adenylate cyclase was demonstrated. The obtained results imply existence of the positive direct insulin-sensitizing effect of liraglutide on mature adipocytes.</description><identifier>ISSN: 0006-2979</identifier><identifier>EISSN: 1608-3040</identifier><identifier>DOI: 10.1134/S000629792103010X</identifier><identifier>PMID: 33838634</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>3T3-L1 Cells ; Adenylate cyclase ; Adenylyl Cyclases - metabolism ; Adipocytes ; Adipocytes - drug effects ; Adipocytes - metabolism ; Adipocytes - physiology ; Adipogenesis ; Adipogenesis - drug effects ; Adipose tissue ; Adipose tissues ; Animals ; Antidiabetics ; Beta cells ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Bioorganic Chemistry ; Glucagon ; Hepatocytes ; Hormones ; Hypoglycemic Agents - pharmacology ; Insulin ; Insulin - metabolism ; Insulin - physiology ; Insulin Resistance ; Life Sciences ; Liraglutide ; Liraglutide - pharmacology ; Mice ; Microbiology ; Obesity - metabolism ; Obesity - physiopathology ; Pancreas ; Pancreatic beta cells ; Peptides ; Sensitivity enhancement ; Sensitizing ; Type 2 diabetes</subject><ispartof>Biochemistry (Moscow), 2021-03, Vol.86 (3), p.350-360</ispartof><rights>Pleiades Publishing, Ltd. 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Pleiades Publishing, Ltd. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-f50df59ff8862d0eec29b8f5a15745122b7aabbed2424c60fa190bc14afcc6453</citedby><cites>FETCH-LOGICAL-c439t-f50df59ff8862d0eec29b8f5a15745122b7aabbed2424c60fa190bc14afcc6453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S000629792103010X$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S000629792103010X$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33838634$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mamontova, Elizaveta D.</creatorcontrib><creatorcontrib>Michurina, Svetlana S.</creatorcontrib><creatorcontrib>Stafeev, Iurii S.</creatorcontrib><creatorcontrib>Sorkina, Ekaterina L.</creatorcontrib><creatorcontrib>Sklyanik, Igor A.</creatorcontrib><creatorcontrib>Koksharova, Ekaterina O.</creatorcontrib><creatorcontrib>Menshikov, Mikhail Y.</creatorcontrib><creatorcontrib>Shestakova, Marina V.</creatorcontrib><creatorcontrib>Parfyonova, Yelena V.</creatorcontrib><title>Direct Effect of the Synthetic Analogue of Glucagon-Like Peptide Type 1, Liraglutide, on Mature Adipocytes Is Realized through Adenylate-Cyclase-Dependent Enhancing of Insulin Sensitivity</title><title>Biochemistry (Moscow)</title><addtitle>Biochemistry Moscow</addtitle><addtitle>Biochemistry (Mosc)</addtitle><description>Incretin hormones analogues, including glucagon-like peptide type 1 (GLP-1), exhibit complex glucose-lowering, anorexigenic, and cardioprotective properties. Mechanisms of action of GLP-1 and its analogues are well known for pancreatic β-cells, hepatocytes, and other tissues. Nevertheless, local effects of GLP-1 and its analogues in adipose tissue remain unclear. In the present work effects of the GLP-1 synthetic analogue, liraglutide, on adipogenesis and insulin sensitivity of the 3T3-L1 adipocytes were examined. Enhancement of insulin sensitivity of mature adipocytes by the GLP-1 synthetic analogue liraglutide mediated by adenylate cyclase was demonstrated. The obtained results imply existence of the positive direct insulin-sensitizing effect of liraglutide on mature adipocytes.</description><subject>3T3-L1 Cells</subject><subject>Adenylate cyclase</subject><subject>Adenylyl Cyclases - metabolism</subject><subject>Adipocytes</subject><subject>Adipocytes - drug effects</subject><subject>Adipocytes - metabolism</subject><subject>Adipocytes - physiology</subject><subject>Adipogenesis</subject><subject>Adipogenesis - drug effects</subject><subject>Adipose tissue</subject><subject>Adipose tissues</subject><subject>Animals</subject><subject>Antidiabetics</subject><subject>Beta cells</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Glucagon</subject><subject>Hepatocytes</subject><subject>Hormones</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Insulin</subject><subject>Insulin - metabolism</subject><subject>Insulin - physiology</subject><subject>Insulin Resistance</subject><subject>Life Sciences</subject><subject>Liraglutide</subject><subject>Liraglutide - pharmacology</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Obesity - metabolism</subject><subject>Obesity - physiopathology</subject><subject>Pancreas</subject><subject>Pancreatic beta cells</subject><subject>Peptides</subject><subject>Sensitivity enhancement</subject><subject>Sensitizing</subject><subject>Type 2 diabetes</subject><issn>0006-2979</issn><issn>1608-3040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1Uktv1DAQjhCILoUfwAVZ4sKhKX4k3uS42pay0iIQWyRukeOMsy5eO7UdpPDX-HM42kLFSz6M_L1mbE2WPSf4nBBWvN5hjDmtlzUlmGGCPz_IFoTjKme4wA-zxUznM3-SPQnhJl0prtnj7ISxilWcFYvs-4X2ICO6VGouTqG4B7SbbCpRS7Sywrh-hJm5MqMUvbP5Vn8B9AGGqDtA19MAiJyhrfaiN-OMnSFn0TsRRw9o1enBySlCQJuAPoIw-ht0qYt3Y79PNNjJiAj5epJGBMgvYACb0DST3Qsrte3n5hsbRqMt2oENOuqvOk5Ps0dKmADP7upp9unN5fX6bb59f7VZr7a5LFgdc1XiTpW1UlXFaYcBJK3bSpWClMuiJJS2SyHaFjpa0EJyrASpcStJIZSUvCjZafbqmDt4dztCiM1BBwnGCAtuDA0tCanqqiZ1kr78Q3rjRp_-cFZhwkq-5MW9qhcGGm2Vi17IObRZ8ZITwpf1nHX-D1U6HRy0dBaUTvhvBnI0SO9C8KCaweuD8FNDcDMvTPPXwiTPi7uBx_YA3S_Hzw1JAnoUhETZHvz9i_6f-gM3kcsa</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Mamontova, Elizaveta D.</creator><creator>Michurina, Svetlana S.</creator><creator>Stafeev, Iurii S.</creator><creator>Sorkina, Ekaterina L.</creator><creator>Sklyanik, Igor A.</creator><creator>Koksharova, Ekaterina O.</creator><creator>Menshikov, Mikhail Y.</creator><creator>Shestakova, Marina V.</creator><creator>Parfyonova, Yelena V.</creator><general>Pleiades Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20210301</creationdate><title>Direct Effect of the Synthetic Analogue of Glucagon-Like Peptide Type 1, Liraglutide, on Mature Adipocytes Is Realized through Adenylate-Cyclase-Dependent Enhancing of Insulin Sensitivity</title><author>Mamontova, Elizaveta D. ; Michurina, Svetlana S. ; Stafeev, Iurii S. ; Sorkina, Ekaterina L. ; Sklyanik, Igor A. ; Koksharova, Ekaterina O. ; Menshikov, Mikhail Y. ; Shestakova, Marina V. ; Parfyonova, Yelena V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-f50df59ff8862d0eec29b8f5a15745122b7aabbed2424c60fa190bc14afcc6453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>3T3-L1 Cells</topic><topic>Adenylate cyclase</topic><topic>Adenylyl Cyclases - metabolism</topic><topic>Adipocytes</topic><topic>Adipocytes - drug effects</topic><topic>Adipocytes - metabolism</topic><topic>Adipocytes - physiology</topic><topic>Adipogenesis</topic><topic>Adipogenesis - drug effects</topic><topic>Adipose tissue</topic><topic>Adipose tissues</topic><topic>Animals</topic><topic>Antidiabetics</topic><topic>Beta cells</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bioorganic Chemistry</topic><topic>Glucagon</topic><topic>Hepatocytes</topic><topic>Hormones</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Insulin</topic><topic>Insulin - metabolism</topic><topic>Insulin - physiology</topic><topic>Insulin Resistance</topic><topic>Life Sciences</topic><topic>Liraglutide</topic><topic>Liraglutide - pharmacology</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Obesity - metabolism</topic><topic>Obesity - physiopathology</topic><topic>Pancreas</topic><topic>Pancreatic beta cells</topic><topic>Peptides</topic><topic>Sensitivity enhancement</topic><topic>Sensitizing</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mamontova, Elizaveta D.</creatorcontrib><creatorcontrib>Michurina, Svetlana S.</creatorcontrib><creatorcontrib>Stafeev, Iurii S.</creatorcontrib><creatorcontrib>Sorkina, Ekaterina L.</creatorcontrib><creatorcontrib>Sklyanik, Igor A.</creatorcontrib><creatorcontrib>Koksharova, Ekaterina O.</creatorcontrib><creatorcontrib>Menshikov, Mikhail Y.</creatorcontrib><creatorcontrib>Shestakova, Marina V.</creatorcontrib><creatorcontrib>Parfyonova, Yelena V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemistry (Moscow)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mamontova, Elizaveta D.</au><au>Michurina, Svetlana S.</au><au>Stafeev, Iurii S.</au><au>Sorkina, Ekaterina L.</au><au>Sklyanik, Igor A.</au><au>Koksharova, Ekaterina O.</au><au>Menshikov, Mikhail Y.</au><au>Shestakova, Marina V.</au><au>Parfyonova, Yelena V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Direct Effect of the Synthetic Analogue of Glucagon-Like Peptide Type 1, Liraglutide, on Mature Adipocytes Is Realized through Adenylate-Cyclase-Dependent Enhancing of Insulin Sensitivity</atitle><jtitle>Biochemistry (Moscow)</jtitle><stitle>Biochemistry Moscow</stitle><addtitle>Biochemistry (Mosc)</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>86</volume><issue>3</issue><spage>350</spage><epage>360</epage><pages>350-360</pages><issn>0006-2979</issn><eissn>1608-3040</eissn><abstract>Incretin hormones analogues, including glucagon-like peptide type 1 (GLP-1), exhibit complex glucose-lowering, anorexigenic, and cardioprotective properties. Mechanisms of action of GLP-1 and its analogues are well known for pancreatic β-cells, hepatocytes, and other tissues. Nevertheless, local effects of GLP-1 and its analogues in adipose tissue remain unclear. In the present work effects of the GLP-1 synthetic analogue, liraglutide, on adipogenesis and insulin sensitivity of the 3T3-L1 adipocytes were examined. Enhancement of insulin sensitivity of mature adipocytes by the GLP-1 synthetic analogue liraglutide mediated by adenylate cyclase was demonstrated. The obtained results imply existence of the positive direct insulin-sensitizing effect of liraglutide on mature adipocytes.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><pmid>33838634</pmid><doi>10.1134/S000629792103010X</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-2979 |
| ispartof | Biochemistry (Moscow), 2021-03, Vol.86 (3), p.350-360 |
| issn | 0006-2979 1608-3040 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2511898919 |
| source | MEDLINE; SpringerLink Journals |
| subjects | 3T3-L1 Cells Adenylate cyclase Adenylyl Cyclases - metabolism Adipocytes Adipocytes - drug effects Adipocytes - metabolism Adipocytes - physiology Adipogenesis Adipogenesis - drug effects Adipose tissue Adipose tissues Animals Antidiabetics Beta cells Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Glucagon Hepatocytes Hormones Hypoglycemic Agents - pharmacology Insulin Insulin - metabolism Insulin - physiology Insulin Resistance Life Sciences Liraglutide Liraglutide - pharmacology Mice Microbiology Obesity - metabolism Obesity - physiopathology Pancreas Pancreatic beta cells Peptides Sensitivity enhancement Sensitizing Type 2 diabetes |
| title | Direct Effect of the Synthetic Analogue of Glucagon-Like Peptide Type 1, Liraglutide, on Mature Adipocytes Is Realized through Adenylate-Cyclase-Dependent Enhancing of Insulin Sensitivity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T11%3A42%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Direct%20Effect%20of%20the%20Synthetic%20Analogue%20of%20Glucagon-Like%20Peptide%20Type%201,%20Liraglutide,%20on%20Mature%20Adipocytes%20Is%20Realized%20through%20Adenylate-Cyclase-Dependent%20Enhancing%20of%20Insulin%20Sensitivity&rft.jtitle=Biochemistry%20(Moscow)&rft.au=Mamontova,%20Elizaveta%20D.&rft.date=2021-03-01&rft.volume=86&rft.issue=3&rft.spage=350&rft.epage=360&rft.pages=350-360&rft.issn=0006-2979&rft.eissn=1608-3040&rft_id=info:doi/10.1134/S000629792103010X&rft_dat=%3Cgale_proqu%3EA656116799%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2501356764&rft_id=info:pmid/33838634&rft_galeid=A656116799&rfr_iscdi=true |